Q9WV78 · PLVAP_RAT

  • Protein
    Plasmalemma vesicle-associated protein
  • Gene
    Plvap
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Endothelial cell-specific membrane protein involved in the formation of the diaphragms that bridge endothelial fenestrae. It is also required for the formation of stomata of caveolae and transendothelial channels. Functions in microvascular permeability, endothelial fenestrae contributing to the passage of water and solutes and regulating transcellular versus paracellular flow in different organs. Plays a specific role in embryonic development.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcaveola
Cellular Componentcell surface
Cellular Componentperinuclear region of cytoplasm
Molecular Functionidentical protein binding
Biological Processdevelopmental process
Biological ProcessMAPK cascade
Biological Processpositive regulation of cellular extravasation
Biological Processregulation of vascular permeability
Biological Processtumor necrosis factor-mediated signaling pathway

Names & Taxonomy

Protein names

  • Recommended name
    Plasmalemma vesicle-associated protein
  • Alternative names
    • Plasmalemma vesicle protein 1 (PV-1)
    • gp68

Gene names

    • Name
      Plvap
    • Synonyms
      Pv1

Organism names

  • Taxonomic identifier
  • Strain
    • Sprague-Dawley
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus

Accessions

  • Primary accession
    Q9WV78

Proteomes

Organism-specific databases

Subcellular Location

Cell membrane
; Single-pass type II membrane protein
Membrane, caveola
; Single-pass type II membrane protein
Note: Membrane-associated protein of caveolae (PubMed:10366592).
Found in fenestral and stomatal diaphragms in fenestrated endothelia and transendothelial channels (PubMed:10557298).
Also colocalized with CAV1 in perinuclear region (PubMed:15640522).

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain1-26Cytoplasmic
Transmembrane27-47Helical; Signal-anchor for type II membrane protein
Topological domain48-438Extracellular

Keywords

PTM/Processing

Features

Showing features for chain, glycosylation.

TypeIDPosition(s)Description
ChainPRO_00000584641-438Plasmalemma vesicle-associated protein
Glycosylation82N-linked (GlcNAc...) asparagine
Glycosylation88N-linked (GlcNAc...) asparagine
Glycosylation112N-linked (GlcNAc...) asparagine
Glycosylation150N-linked (GlcNAc...) asparagine

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Expressed in lung (alveolar endothelial and bronchial epithelial cells), kidney (endothelium of peritubular capillaries), spleen, liver, adrenal (endothelial cells of the zona reticularis of the cortex and chromaffin cells in the medulla), pancreas (islets of Langerhans), testis (germ cells, interstitial cells in neonatal testis and spermatids), ovary (stromal endothelial, thecal layer of developing follicles, luteal cells within the corpus luteum), intestine (endothelium of capillaries of the intestinal villi) and pituitary (pituicyte cells in the neural lobe) (at protein level). Expressed in lung, kidney, spleen, liver, adrenal, testis, heart, muscle, pituitary, thyroid and ovary.

Developmental stage

Expressed in endothelial cells of the lung at 12 dpc.

Gene expression databases

Interaction

Subunit

Homodimer.

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for coiled coil, region, compositional bias.

TypeIDPosition(s)Description
Coiled coil289-383
Region393-438Disordered
Compositional bias396-411Pro residues

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    438
  • Mass (Da)
    50,033
  • Last updated
    1999-11-01 v1
  • Checksum
    99A016CDD12568C2
MGLSMDRSPYSRTGDRDRGCWYYLRYFFLFVSLIQFLIILGLVLFMIYGNVHATTESSLRATEIRADNLYSQVVGLSAAQANLSKQLNISTLVKDTVMQQLLTTRREVERINASFRQCQGDLITYINYNRFIAAIILSEKQCQEQLKEGNKTCEALLFKLGEKVKTLEMEVVKEKAVCSKDKDSLLAGKRQAEMQQEACGKAREQQKQDQQVTEEQLRKVQSLCLPLDQEKFQADVLNVWRDSLVYRSLDNIGYHYSLMPEFSSLRRTCESLPGIMTTKVEELARGLRAGIERVTRENGELRRQKLELERAIQGEREARTRAGTEAQARETQLRTECARQTQLALEEKAALRTQRDDLERQLEARKRELEQLRTEVDVRISALDTCVKAKSLPAIQPRLPGPPPNPPPIDPASLEEFKKRILESQRPPLVNPAVPPSG

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
A0A0G2JZ75A0A0G2JZ75_RATPlvap401

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias396-411Pro residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF154831
EMBL· GenBank· DDBJ
AAD41524.1
EMBL· GenBank· DDBJ
mRNA
BC070900
EMBL· GenBank· DDBJ
AAH70900.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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