FUNCTION, SUBCELLULAR LOCATION, SUBUNIT, PHOSPHORYLATION AT SER-260 AND THR-278, MUTAGENESIS OF GLN-241; LYS-257; SER-260; GLY-277; THR-278 AND ARG-335
Global Arc knockout mice have altered AMPAR-subunit surface levels in the adult NAc and the Arc-deficient mice show reductions in anxiety-like behavior deficits in social novelty preference and antidepressive-like behavior.
These results demonstrate that Arc/Arg3.1 mediates a critical period for spatial learning during which Arc/Arg3.1 fosters maturation of hippocampal network activity necessary for future learning and memory storage.
ArcKR (with mutation causing disrupted temporal control of degradation) mice had intact spatial learning but showed specific deficits in selecting an optimal strategy during reversal learning. This cognitive inflexibility was coupled to changes in Arc mRNA and protein expression resulting in a reduced threshold to induce mGluR-LTD and enhanced mGluR-LTD amplitude.
Our data support the hypothesis that the kinetics of Arc induction to refine cortical representations of sensory categories is sensitive to the familiarity of the sensory experience.
These data indicate that suppression of CHOP by endogenous levels of ARC is critical for beta-cell viability and maintenance of normal islet structure in this model of type 2 diabetes.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.