Q9WUW8 · ST1C2_RAT
- ProteinSulfotransferase 1C2
- GeneSult1c2
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids296 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
function
Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of phenolic compounds. Does not sulfonate steroids, dopamine, acetaminophen, or alpha-naphthol. Catalyzes the sulfonation of the carcinogenic N-Hydroxy-2-acetylaminofluorene leading to highly reactive intermediates capable of forming DNA adducts, potentially resulting in mutagenesis (By similarity).
Catalytic activity
- 3'-phosphoadenylyl sulfate + a phenol = adenosine 3',5'-bisphosphate + an aryl sulfate + H+
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 49-54 | 3'-phosphoadenylyl sulfate (UniProtKB | ChEBI) | ||||
Sequence: KSGTTW | ||||||
Binding site | 107-109 | substrate | ||||
Sequence: RTH | ||||||
Active site | 109 | Proton acceptor | ||||
Sequence: H | ||||||
Binding site | 131 | 3'-phosphoadenylyl sulfate (UniProtKB | ChEBI) | ||||
Sequence: R | ||||||
Binding site | 139 | 3'-phosphoadenylyl sulfate (UniProtKB | ChEBI) | ||||
Sequence: S | ||||||
Binding site | 194 | 3'-phosphoadenylyl sulfate (UniProtKB | ChEBI) | ||||
Sequence: Y | ||||||
Binding site | 228-233 | 3'-phosphoadenylyl sulfate (UniProtKB | ChEBI) | ||||
Sequence: TSFEKM | ||||||
Binding site | 256-260 | 3'-phosphoadenylyl sulfate (UniProtKB | ChEBI) | ||||
Sequence: FMRKG |
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | lysosome | |
Molecular Function | aryl sulfotransferase activity | |
Biological Process | sulfation |
Keywords
- Molecular function
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameSulfotransferase 1C2
- EC number
- Short namesST1C2; rSULT1C2
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus
Accessions
- Primary accessionQ9WUW8
- Secondary accessions
Proteomes
Organism-specific databases
PTM/Processing
Features
Showing features for chain, modified residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000085135 | 1-296 | Sulfotransferase 1C2 | |||
Sequence: MALAPELSRQTKLKEVAGIPLQAPTVDNWSQIQTFKAKPDDLLICTYPKSGTTWIQEIVDMIEQNGDVEKCQRTIIQHRHPFIEWARPPQPSGVDKANAMPAPRILRTHLPTQLLPPSFWTNNCKFLYVARNAKDCMVSYYHFYRMSQVLPDPGTWNEYFETFINGKVSWGSWFDHVKGWWEIRDRYQILFLFYEDMKRDPKREIQKVMQFMGKNLDEEVVDKIVLETSFEKMKENPMTNRSTVPKSVLDQSISPFMRKGTVGDWKNHFTVAQNDRFDEIYKQKMGGTSLNFCMEL | ||||||
Modified residue | 139 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 254 | Phosphoserine | ||||
Sequence: S |
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Tissue specificity
Highly expressed in kidney and at lower levels in stomach and liver. More specifically found in the epithelia of proximal tubules of the kidney, of the bile duct, of the gastric mucosa, and in hepatocytes.
Induction
Down-regulated in kidney but not in stomach following feeding with 2-amino-4,5-diphenylthiazole.
Gene expression databases
Interaction
Protein-protein interaction databases
Structure
Sequence
- Sequence statusComplete
- Length296
- Mass (Da)34,731
- Last updated2021-09-29 v2
- Checksum21F33DC241AEBFA4
Computationally mapped potential isoform sequences
There are 4 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
F1LNK1 | F1LNK1_RAT | LOC120093086 | 296 | ||
A0A8I6ARK1 | A0A8I6ARK1_RAT | Sult1c2 | 296 | ||
A0A0G2JUM0 | A0A0G2JUM0_RAT | Sult1c2 | 296 | ||
F1LZI5 | F1LZI5_RAT | Sult1c2 | 288 |
Features
Showing features for sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Sequence conflict | 197 | in Ref. 1; CAB41460 | ||||
Sequence: M → V |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AJ238391 EMBL· GenBank· DDBJ | CAB41460.1 EMBL· GenBank· DDBJ | mRNA | ||
AABR07066190 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AABR07066204 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AABR07066203 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AABR07066194 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AABR07066193 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AABR07066192 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AABR07066191 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
BC103636 EMBL· GenBank· DDBJ | AAI03637.1 EMBL· GenBank· DDBJ | mRNA |