Q9WUW8 · ST1C2_RAT

  • Protein
    Sulfotransferase 1C2
  • Gene
    Sult1c2
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    4/5

Function

function

Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of phenolic compounds. Does not sulfonate steroids, dopamine, acetaminophen, or alpha-naphthol. Catalyzes the sulfonation of the carcinogenic N-Hydroxy-2-acetylaminofluorene leading to highly reactive intermediates capable of forming DNA adducts, potentially resulting in mutagenesis (By similarity).

Catalytic activity

Features

Showing features for binding site, active site.

129620406080100120140160180200220240260280
TypeIDPosition(s)Description
Binding site49-543'-phosphoadenylyl sulfate (UniProtKB | ChEBI)
Binding site107-109substrate
Active site109Proton acceptor
Binding site1313'-phosphoadenylyl sulfate (UniProtKB | ChEBI)
Binding site1393'-phosphoadenylyl sulfate (UniProtKB | ChEBI)
Binding site1943'-phosphoadenylyl sulfate (UniProtKB | ChEBI)
Binding site228-2333'-phosphoadenylyl sulfate (UniProtKB | ChEBI)
Binding site256-2603'-phosphoadenylyl sulfate (UniProtKB | ChEBI)

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytoplasm
Cellular Componentlysosome
Molecular Functionaryl sulfotransferase activity
Biological Processsulfation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Sulfotransferase 1C2
  • EC number
  • Short names
    ST1C2; rSULT1C2
  • Alternative names
    • Sulfotransferase K1

Gene names

    • Name
      Sult1c2
    • Synonyms
      Sultk1

Organism names

  • Taxonomic identifier
  • Strain
    • Brown Norway
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus

Accessions

  • Primary accession
    Q9WUW8
  • Secondary accessions
    • F1LZL1
    • Q3ZAV3

Proteomes

Organism-specific databases

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain, modified residue.

TypeIDPosition(s)Description
ChainPRO_00000851351-296Sulfotransferase 1C2
Modified residue139Phosphoserine
Modified residue254Phosphoserine

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Highly expressed in kidney and at lower levels in stomach and liver. More specifically found in the epithelia of proximal tubules of the kidney, of the bile duct, of the gastric mucosa, and in hepatocytes.

Induction

Down-regulated in kidney but not in stomach following feeding with 2-amino-4,5-diphenylthiazole.

Gene expression databases

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Belongs to the sulfotransferase 1 family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    296
  • Mass (Da)
    34,731
  • Last updated
    2021-09-29 v2
  • Checksum
    21F33DC241AEBFA4
MALAPELSRQTKLKEVAGIPLQAPTVDNWSQIQTFKAKPDDLLICTYPKSGTTWIQEIVDMIEQNGDVEKCQRTIIQHRHPFIEWARPPQPSGVDKANAMPAPRILRTHLPTQLLPPSFWTNNCKFLYVARNAKDCMVSYYHFYRMSQVLPDPGTWNEYFETFINGKVSWGSWFDHVKGWWEIRDRYQILFLFYEDMKRDPKREIQKVMQFMGKNLDEEVVDKIVLETSFEKMKENPMTNRSTVPKSVLDQSISPFMRKGTVGDWKNHFTVAQNDRFDEIYKQKMGGTSLNFCMEL

Computationally mapped potential isoform sequences

There are 4 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
F1LNK1F1LNK1_RATLOC120093086296
A0A8I6ARK1A0A8I6ARK1_RATSult1c2296
A0A0G2JUM0A0A0G2JUM0_RATSult1c2296
F1LZI5F1LZI5_RATSult1c2288

Features

Showing features for sequence conflict.

TypeIDPosition(s)Description
Sequence conflict197in Ref. 1; CAB41460

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AJ238391
EMBL· GenBank· DDBJ
CAB41460.1
EMBL· GenBank· DDBJ
mRNA
AABR07066190
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AABR07066204
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AABR07066203
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AABR07066194
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AABR07066193
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AABR07066192
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AABR07066191
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
BC103636
EMBL· GenBank· DDBJ
AAI03637.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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