Q9WUV2 · SIA7C_MOUSE

  • Protein
    Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3
  • Gene
    St6galnac3
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Transfers the sialyl group (N-acetyl-alpha-neuraminyl or NeuAc) from CMP-NeuAc to the GalNAc residue on the NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc sequence of glycoproteins and glycolipids forming an alpha-2,6-linkage. Produces branched type disialyl structures by transfer of a sialyl group onto a GalNAc residue inside the backbone core chains. ST6GalNAcIII prefers glycolipids to glycoproteins, predominantly catalyzing the biosynthesis of ganglioside GD1alpha from GM1b (PubMed:10207017, PubMed:10601645).
GD1alpha is a critical molecule in the communication and interaction between neuronal cells and their supportive cells, particularly in brain tissues, and functions as an adhesion molecule in the process of metastasis (By similarity).
Sialylation of glycoproteins or glycosphingolipids is very important in tumor development, neuronal development, nerve repair, immunological processes and regulation of hormone sensitivity (By similarity).

Catalytic activity

  • an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-D-GlcNAc derivative + CMP-N-acetyl-beta-neuraminate = an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-[alpha-Neu5Ac-(2->6)]-D-GlcNAc-R + CMP + H+
    This reaction proceeds in the forward direction.
    EC:2.4.3.7 (UniProtKB | ENZYME | Rhea)
  • a ganglioside GM1b (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate = a ganglioside GD1alpha (d18:1(4E)) + CMP + H+
    This reaction proceeds in the forward direction.
  • a globoside MSGG + CMP-N-acetyl-beta-neuraminate = a globoside DSGG + CMP + H+
    This reaction proceeds in the forward direction.
  • 3-O-[alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-alpha-D-GalNAc]-L-Ser-[protein] + CMP-N-acetyl-beta-neuraminate = 3-O-{alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-[alpha-Neu5Ac-(2->6)]-alpha-D-GalNAc}-L-Ser-[protein] + CMP + H+
    This reaction proceeds in the forward direction.
  • 3-O-[alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-alpha-D-GalNAc]-L-Thr-[protein] + CMP-N-acetyl-beta-neuraminate = 3-O-{alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-[alpha-Neu5Ac-(2->6)]-alpha-D-GalNAc}-L-Thr-[protein] + CMP + H+
    This reaction proceeds in the forward direction.

Pathway

Protein modification; protein glycosylation.
Glycolipid biosynthesis.

GO annotations

AspectTerm
Cellular ComponentGolgi membrane
Cellular Componentnucleoplasm
Molecular Functionalpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity
Molecular Functionalpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3-N-acetyl-galactosaminide 6-alpha-sialyltransferase activity
Molecular Functionsialyltransferase activity
Biological Processganglioside biosynthetic process
Biological Processglycosylceramide metabolic process
Biological Processoligosaccharide metabolic process
Biological Processprotein glycosylation

Keywords

Enzyme and pathway databases

Protein family/group databases

Chemistry

Names & Taxonomy

Protein names

  • Recommended name
    Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3
  • EC number
  • Alternative names
    • GalNAc alpha-2,6-sialyltransferase III
    • ST6GalNAc III
      (ST6GalNAcIII)
    • STY
    • Sialyltransferase 7C (SIAT7-C)

Gene names

    • Name
      St6galnac3
    • Synonyms
      Siat7c

Organism names

  • Taxonomic identifier
  • Strains
    • ICR
    • C57BL/6J
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    Q9WUV2
  • Secondary accessions
    • Q9JHP5

Proteomes

Organism-specific databases

Subcellular Location

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain1-8Cytoplasmic
Transmembrane9-28Helical; Signal-anchor for type II membrane protein
Topological domain29-305Lumenal

Keywords

PTM/Processing

Features

Showing features for chain, disulfide bond, glycosylation.

TypeIDPosition(s)Description
ChainPRO_00001492761-305Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3
Disulfide bond80↔229
Glycosylation239N-linked (GlcNAc...) asparagine
Glycosylation301N-linked (GlcNAc...) asparagine

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

In adult tissues, high expression in brain, lung and heart and to a lesser extent in kidney, mammary gland, spleen, testis and thymus.

Developmental stage

In brain, expression reaches maximum levels at day 12 of the embryonic stage. Keeps almost similar levels during mouse development.

Gene expression databases

Interaction

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Sequence similarities

Belongs to the glycosyltransferase 29 family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    305
  • Mass (Da)
    35,414
  • Last updated
    2001-03-01 v2
  • Checksum
    63C7498615BF6A3F
MACILKRKPVLVVSFIALCILLLAMRLVNDATFPLLLNCFGQPKTKWIPLPYTFRQPLRTHYGYINVRTQEPLQLNCNHCAIVSNSGQMVGQKVGEEIDHASCIWRMNNAPTKGFEEDVGYMTMVRVVSHTSVPLLLKNPDYFFKEASRTIYVIWGPFRNMRKDGNGIVYNMLKKTVDAYPDAQIYVTTEQQMTHCDRVFKDETGKDRVQSGSYLSTGWFTFILAMDACYSIHVYGMINETYCKTEGYRKVPYHYYEQGKDECNEYLLHEHAPYGGHRFITEKKVFAKWAKKHRIVFTHPNWTLS

Computationally mapped potential isoform sequences

There are 2 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A0H2UKC4A0A0H2UKC4_MOUSESt6galnac3196
A0A0G2JF56A0A0G2JF56_MOUSESt6galnac3125

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
Y11342
EMBL· GenBank· DDBJ
CAA72181.2
EMBL· GenBank· DDBJ
mRNA
Y11343
EMBL· GenBank· DDBJ
CAB95031.1
EMBL· GenBank· DDBJ
Genomic DNA
Y11344
EMBL· GenBank· DDBJ
CAB95031.1
EMBL· GenBank· DDBJ
Genomic DNA
Y11345
EMBL· GenBank· DDBJ
CAB95031.1
EMBL· GenBank· DDBJ
Genomic DNA
Y11346
EMBL· GenBank· DDBJ
CAB95031.1
EMBL· GenBank· DDBJ
Genomic DNA
BC058387
EMBL· GenBank· DDBJ
AAH58387.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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