Q9WTZ9 · BEX3_MOUSE
- ProteinProtein BEX3
- GeneBex3
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids124 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
May be a signaling adapter molecule involved in NGFR/p75NTR-mediated apoptosis induced by NGF (PubMed:10764727).
Plays a role in zinc-triggered neuronal death (PubMed:10764727).
In absence of reductive stress, acts as a pseudosubstrate for the CRL2(FEM1B) complex: associates with FEM1B via zinc, thereby preventing association between FEM1B and its substrates (PubMed:34562363).
Plays a role in zinc-triggered neuronal death (PubMed:10764727).
In absence of reductive stress, acts as a pseudosubstrate for the CRL2(FEM1B) complex: associates with FEM1B via zinc, thereby preventing association between FEM1B and its substrates (PubMed:34562363).
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 121 | Zn2+ (UniProtKB | ChEBI); ligand shared with FEM1B | |||
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | cytosol | |
Cellular Component | nucleus | |
Molecular Function | death receptor binding | |
Molecular Function | identical protein binding | |
Molecular Function | metal ion binding | |
Molecular Function | molecular function inhibitor activity | |
Molecular Function | nerve growth factor receptor binding | |
Biological Process | extrinsic apoptotic signaling pathway via death domain receptors | |
Biological Process | negative regulation of protein ubiquitination |
Keywords
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameProtein BEX3
- Alternative names
Gene names
Organism names
- Organism
- Strains
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionQ9WTZ9
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Keywords
- Cellular component
Phenotypes & Variants
Features
Showing features for mutagenesis.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Mutagenesis | 94 | Abolishes nuclear export and interactions with itself and p75NTR/NGFR; when associated with A-97 and A-99. | |||
Mutagenesis | 97 | Abolishes nuclear export and interactions with itself and p75NTR/NGFR; when associated with A-97 and A-99. | |||
Mutagenesis | 99 | Abolishes nuclear export and interactions with itself and p75NTR/NGFR; when associated with A-94 and A-97. | |||
Mutagenesis | 113-117 | Abolished zinc-binding and association with FEM1B. | |||
Mutagenesis | 121 | Abolishes localization with replicating mitochondria. | |||
Mutagenesis | 121 | Abolished zinc-binding and association with FEM1B. | |||
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 2 variants from UniProt as well as other sources including ClinVar and dbSNP.
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000229781 | 1-124 | Protein BEX3 | ||
Post-translational modification
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Structure
Family & Domains
Features
Showing features for region, motif.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Region | 1-56 | Disordered | |||
Region | 81-106 | Interaction with p75NTR/NGFR | |||
Region | 81-124 | Interaction with 14-3-3 epsilon | |||
Motif | 90-100 | Nuclear export signal | |||
Region | 113-117 | His cluster | |||
Domain
The nuclear export signal is required for export from the nucleus and the interactions with itself and NGFR/p75NTR.
The histidine cluster (His cluster) and Cys-121 mediate zinc-binding.
Sequence similarities
Belongs to the BEX family.
Phylogenomic databases
Family and domain databases
Sequence & Isoform
- Sequence statusComplete
This entry describes 2 isoforms produced by Alternative splicing.
Q9WTZ9-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- Length124
- Mass (Da)14,542
- Last updated1999-11-01 v1
- Checksum3CCCD4F05E66F461
Q9WTZ9-2
- Name2
- Differences from canonical
- 1-10: Missing
Sequence caution
Features
Showing features for alternative sequence, sequence conflict.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Alternative sequence | VSP_017744 | 1-10 | in isoform 2 | ||
Sequence conflict | 17 | in Ref. 4; BAB26986 | |||
Sequence conflict | 82 | in Ref. 4; BAB22697 | |||
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AF097440 EMBL· GenBank· DDBJ | AAD24431.1 EMBL· GenBank· DDBJ | mRNA | ||
AF187066 EMBL· GenBank· DDBJ | AAF75131.1 EMBL· GenBank· DDBJ | mRNA | ||
AK003294 EMBL· GenBank· DDBJ | BAB22697.1 EMBL· GenBank· DDBJ | mRNA | ||
AK004531 EMBL· GenBank· DDBJ | BAB23350.1 EMBL· GenBank· DDBJ | mRNA | Sequence problems. | |
AK010500 EMBL· GenBank· DDBJ | BAB26986.1 EMBL· GenBank· DDBJ | mRNA | ||
AL671493 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
BC027815 EMBL· GenBank· DDBJ | AAH27815.1 EMBL· GenBank· DDBJ | mRNA |