Neonatal maternal separation (MS) lead to increased anxiety-like behavior in Cdh13(-/-) mice compared to the other two MS groups. Cdh13(-/-) mice showed a context-dependent effect on stress- & anxiety-related behavior impaired extinction learning following contextual fear conditioning & decreased impulsivity & a mild decrease in errors in the Barnes maze & reduced risk-taking in the light-dark transition test after MS.
Findings show that Cdh13 is critical for inhibitory function of Golgi cells and that GlyT2::Cre-mediated deletion of Cdh13 in non-executive centers of the brain such as the cerebellum may contribute to cognitive and social behavioral deficits linked to neurological disorders.
using rat and murine aortic smooth muscle cells as experimental models we surveyed the ability of T-cadherin to regulate autophagy in SMCs during serum-starvation stress. Overall our findings have identified T-cadherin as a novel positive regulator of autophagy and survival in smooth muscle cells
T-cadherin was essential for accumulation of adiponectin in the neointima and atherosclerotic plaque lesions and the adiponectin-T-cadherin association protected against vascular injury.
These data show that both circulating and tissue-bound Adipo levels are dependent on Tcad and in reverse regulate tissue Tcad levels through a positive feedback loop.
These data highlight a previously unrecognized role for T-cadherin in limb revascularization and show that it is essential for mediating the vascular actions of adiponectin.
hyperexpression of T-cadherin in the B16F10 cells suppresses the proliferation of these cells in vitro and the growth of the tumor masses formed by melanoma cells on the chorioallantoic membrane and their neovascularization
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