Q9WTP5 · CAD22_MOUSE

  • Protein
    Cadherin-22
  • Gene
    Cdh22
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    4/5

Function

function

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. PB-cadherins may have a role in the morphological organization of pituitary gland and brain tissues.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentadherens junction
Cellular Componentcatenin complex
Molecular Functionbeta-catenin binding
Molecular Functioncadherin binding
Molecular Functioncalcium ion binding
Biological Processadherens junction organization
Biological Processcalcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules
Biological Processcell migration
Biological Processcell morphogenesis
Biological Processcell-cell adhesion mediated by cadherin
Biological Processcell-cell junction assembly
Biological Processhomophilic cell adhesion via plasma membrane adhesion molecules

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Cadherin-22
  • Alternative names
    • Pituitary and brain cadherin (PB-cadherin)

Gene names

    • Name
      Cdh22

Organism names

  • Taxonomic identifier
  • Strains
    • ICR
    • C57BL/6J
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    Q9WTP5
  • Secondary accessions
    • I7HIP9

Proteomes

Organism-specific databases

Subcellular Location

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain34-621Extracellular
Transmembrane622-642Helical
Topological domain643-813Cytoplasmic

Keywords

PTM/Processing

Features

Showing features for signal, chain, glycosylation.

TypeIDPosition(s)Description
Signal1-33
ChainPRO_000000382234-813Cadherin-22
Glycosylation159N-linked (GlcNAc...) asparagine
Glycosylation463N-linked (GlcNAc...) asparagine
Glycosylation609N-linked (GlcNAc...) asparagine

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Predominantly expressed in brain. Abundant in olfactory bulb, cerebrum, and cerebellum, less in pons, medulla, and spinal cord. Low expression in heart. No expression in lung, liver, spleen, kidney, testis, stomach, intestine, colon, and placenta.

Induction

Down-regulated by thyroid hormone.

Developmental stage

Expressed at 9.5 dpc onwards. At 10.5 dpc, in brain (telencephalic vesicles and isthmus), spinal cord and limb buds (in the zone of polarizing activity). At 14.5 dpc, in olfactory bulb and cerebellum.

Gene expression databases

Interaction

Protein-protein interaction databases

Miscellaneous

Family & Domains

Features

Showing features for domain, region.

TypeIDPosition(s)Description
Domain61-165Cadherin 1
Domain166-274Cadherin 2
Domain275-391Cadherin 3
Domain392-495Cadherin 4
Domain496-613Cadherin 5
Region696-726Disordered

Domain

Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    813
  • Mass (Da)
    87,953
  • Last updated
    2013-09-18 v2
  • Checksum
    BC0267FD6A6B15D8
MRPRPEGALRAGAALSPVLLFLLLLPLLGHLWAASTPAPSSLSPGAQEDNQLGAGRVKRGWVWNQFFVVEEYTGTEPLYVGKIHSDSDEGDGTIKYTISGEGAGTIFLIDELTGDIHATERLDREQKTFYTLRAQARDRATNRLLEPESEFIIKVQDINDSEPRFLHGPYIGSVAELSPTGTSVMQVMASDADDPTYGSSARLVYSVLDGEHHFTVDPKTGVIRTAVPDLDRESQERYEVVIQATDMAGQLGGLSGSTTVTIVVTDVNDNPPRFPQKMYQFSIQESAPIGTAVGRVKAEDSDVGENTDMTYHLREESGSGGDAFKVTTDSDTQEAIIVVQKHLDFESQQVHTVVLEALNKFVDPRFADLGTFRDQAIVRVAVTDVDEPPEFRPPSGLLEVQEDAQVGSLVGVVTARDPDAANRPVRYAIDRDSDLEQIFDIDADTGAIVTGKGLDRETAGWHNITVLAMEADNHAQLSRASLRIRILDVNDNPPELATPYEAAVCEDAKPGQLIQTISVVDRDEPQGGHRFYFRLVPEAPSNPHFSLLDIEDNTAAVHTQHVGFNRQEQDVFLLPILVVDSGPPTLSSTGTLTIRICGCDSSGTIQSCNTTAFVMAASLSPGALIALLVCVLILVVLALLILTLRRHHKSHLSSDVDEDMRDNVIKYNDEGGGEQDTEAYDMSALRSLYDFGELKGGDPGGGAASPPQAASSSERHSLPRGPSSPEPDFSVFRDFISRKVALADADLSVPPYDAFQTYAFEGAGSPAASLSSLHSGSTGSEQDFAFLRAWGPRFRPLAALYAGHRGDDEAPAS

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
I6L9J1I6L9J1_MOUSECdh22408

Features

Showing features for sequence conflict.

TypeIDPosition(s)Description
Sequence conflict199in Ref. 1; BAA34426

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AB019618
EMBL· GenBank· DDBJ
BAA34426.1
EMBL· GenBank· DDBJ
mRNA
AL591411
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AL591430
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.

Genome annotation databases

Similar Proteins

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