Q9W7R4 · TEN3_DANRE

Function

function

Involved in neural development by regulating the establishment of proper connectivity within the nervous system (PubMed:24183672, PubMed:27374343).
Acts in both pre- and postsynaptic neurons in the hippocampus to control the assembly of a precise topographic projection: required in both CA1 and subicular neurons for the precise targeting of proximal CA1 axons to distal subiculum, probably by promoting homophilic cell adhesion (By similarity).
Required by retinal ganglion cells for acquisition of their correct morphological and functional connectivity, thereby playing a key role in the development of the visual pathway (PubMed:24183672, PubMed:27374343).

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentaxon
Cellular Componentmembrane
Cellular Componentneuron projection
Cellular Componentplasma membrane
Molecular Functioncell adhesion molecule binding
Molecular Functionprotein heterodimerization activity
Molecular Functionprotein homodimerization activity
Biological Processdendrite guidance
Biological Processheterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
Biological Processhomophilic cell adhesion via plasma membrane adhesion molecules
Biological Processneuron development
Biological Processpositive regulation of neuron projection development
Biological Processregulation of homophilic cell adhesion
Biological Processretinal ganglion cell axon guidance
Biological Processsignal transduction
Biological Processvisual perception

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Teneurin-3
  • Short names
    Ten-3
  • Alternative names
    • Protein Odd Oz/ten-m homolog 3
    • Tenascin-M3 (Ten-m3)
    • Teneurin transmembrane protein 3

Gene names

    • Name
      tenm3
    • Synonyms
      odz3, tnm3

Organism names

  • Taxonomic identifier
  • Strain
    • Tuebingen
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Cypriniformes > Danionidae > Danioninae > Danio

Accessions

  • Primary accession
    Q9W7R4
  • Secondary accessions
    • E7EYS1

Proteomes

Organism-specific databases

Subcellular Location

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain1-312Cytoplasmic
Transmembrane313-333Helical
Topological domain334-2694Extracellular

Keywords

Phenotypes & Variants

Disruption phenotype

Morpholino knockdown of the protein causes retinal ganglion cell dendrite stratification defects within the inner plexiform layer, as well as mistargeting of dendritic processes into outer portions of the retina.

PTM/Processing

Features

Showing features for chain, glycosylation, disulfide bond.

TypeIDPosition(s)Description
ChainPRO_00002595071-2694Teneurin-3
Glycosylation374N-linked (GlcNAc...) asparagine
Glycosylation413N-linked (GlcNAc...) asparagine
Disulfide bond512↔522
Disulfide bond516↔527
Disulfide bond529↔538
Disulfide bond547↔558
Disulfide bond560↔569
Disulfide bond576↔587
Disulfide bond581↔592
Disulfide bond594↔603
Disulfide bond608↔619
Disulfide bond613↔624
Disulfide bond626↔635
Disulfide bond646↔659
Disulfide bond661↔670
Glycosylation664N-linked (GlcNAc...) asparagine
Disulfide bond675↔685
Disulfide bond679↔690
Disulfide bond692↔701
Disulfide bond706↔716
Disulfide bond710↔721
Disulfide bond723↔732
Disulfide bond737↔747
Disulfide bond741↔756
Disulfide bond758↔767
Glycosylation854N-linked (GlcNAc...) asparagine
Glycosylation877N-linked (GlcNAc...) asparagine
Glycosylation1048N-linked (GlcNAc...) asparagine
Glycosylation1196N-linked (GlcNAc...) asparagine
Glycosylation1521N-linked (GlcNAc...) asparagine
Glycosylation1538N-linked (GlcNAc...) asparagine
Glycosylation1634N-linked (GlcNAc...) asparagine
Glycosylation1671N-linked (GlcNAc...) asparagine
Glycosylation1729N-linked (GlcNAc...) asparagine
Glycosylation1814N-linked (GlcNAc...) asparagine
Glycosylation1915N-linked (GlcNAc...) asparagine
Glycosylation2118N-linked (GlcNAc...) asparagine
Glycosylation2258N-linked (GlcNAc...) asparagine
Glycosylation2571N-linked (GlcNAc...) asparagine

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Expressed by retinal ganglion cells and their presynaptic amacrine and postsynaptic tectal cell targets.

Developmental stage

Expressed at the notochord and the somite around tailbud stage. At 14 hours post-fertilization (hpf), expressed in the somites, notochord, and the brain. Found in the rhombomere 3 (r3) and r5. Expressed in the optic vesicles and a region covering the caudal diencephalon and the mesencephalon with the strongest expression at its most anterior part. Mesodermal expression is observed in both forming and formed somites. In forming and newly formed somites, transcripts are distributed evenly. In contrast, distribution in somites located on more anterior trunk seems to be uneven, strongest in the ventral, intermediate in the dorsal, and weakest in the medial parts. At 23 hpf, there is no expression in the medial parts of somites. Expression in somites fades away by 36 hpf. At 20 hpf, additional expression is detected in the pharyngeal arches.

Gene expression databases

Interaction

Subunit

Homodimer; disulfide-linked; to mediate homophilic cell adhesion.

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for compositional bias, region, domain, repeat.

TypeIDPosition(s)Description
Compositional bias1-28Basic and acidic residues
Region1-45Disordered
Domain1-306Teneurin N-terminal
Compositional bias30-45Polar residues
Region106-132Disordered
Region161-198Disordered
Compositional bias163-182Polar residues
Domain508-539EGF-like 1
Domain540-570EGF-like 2
Domain572-604EGF-like 3
Domain605-636EGF-like 4
Domain638-671EGF-like 5
Domain672-703EGF-like 6
Domain704-733EGF-like 7
Domain734-768EGF-like 8
Repeat1166-1192NHL 1
Repeat1194-1238NHL 2
Repeat1264-1308NHL 3
Repeat1325-1365NHL 4
Repeat1452-1495NHL 5
Repeat1505-1524YD 1
Repeat1541-1561YD 2
Repeat1604-1623YD 3
Repeat1624-1646YD 4
Repeat1817-1836YD 5
Repeat1858-1876YD 6
Repeat1877-1897YD 7
Repeat1904-1921YD 8
Repeat1922-1943YD 9
Repeat1944-1961YD 10
Repeat1964-1984YD 11
Repeat1987-2007YD 12
Repeat2015-2034YD 13
Repeat2040-2057YD 14
Repeat2058-2084YD 15
Repeat2086-2099YD 16
Repeat2100-2123YD 17
Repeat2126-2146YD 18
Repeat2147-2167YD 19
Repeat2169-2189YD 20
Repeat2201-2221YD 21
Repeat2223-2243YD 22
Repeat2269-2310YD 23

Sequence similarities

Belongs to the tenascin family. Teneurin subfamily.

Keywords

Phylogenomic databases

Family and domain databases

Sequence & Isoform

Align isoforms (2)
  • Sequence status
    Complete

This entry describes 2 isoforms produced by Alternative splicing.

Q9W7R4-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Length
    2,694
  • Mass (Da)
    300,669
  • Last updated
    2018-04-25 v2
  • Checksum
    65C41528CC4B4A10
MDVKERRPYCSLTKSRREKERRYTGSSGDSEDCRVPTQKSYSSSETLKAFDHDSSRLLYGGHVKEMVHREADEYSRQGQNFNLRQLGICEPATRRGLAFCAEMGMPSSLSSPSVTEHSHSQPPSPNLHDNQSSILSNATTQAVQDSDSEEEYTAVLYRPVTQPAPSHSCNEQPSNQHQQGQSTLPPVPPPHKQQPSVTALNHNSLSSRRNVSPAPPAALPAELQTTPESVPLQDSWVLGSNVPLESRHFLFKTGTGTTPLFSTATPGYTMATGAVYSPPTRPLPRNTLSRSAFKFKKSSKYCSWRCTALSAMAVSILLSVLLCYCIAMHLFGLNWQLQETEGYAFENGQVKSDSTATNAVTALSTENKVYFQENNTIDTGEVDVGRRAVQDVPPGTFWRTQLFIDQPQSLKFNISVQRGALVGVYGRKGLPPTHTQYDFVELLDGSRLIAKEKRGLVEVEGAARKARSVNVHEAEFIRFLDSGTWHLAFYNDGKNAEQVSYNTIIIDTLTECPHNCHGNGDCRTGTCHCFPGFLGPDCSRAACPVLCSGNGQYSRGRCLCYSGWKGTECDVPSNQCIDIHCSGHGICIMGTCACNTGYKGDNCEEVDCLDPSCSSHGVCIHGECHCNPGWGGNNCEILKTMCPDQCSGHGTYQTESGTCTCDTNWTGPDCSIEVCAVDCGSHGVCIGGSCRCEEGWTGSVCDLKACHPRCTEHGTCKDGKCECHQGWTGEHCTVEGCPGLCNSNGRCTLDQNGWHCVCQPGWRGAGCDVAMETLCADGKDNEGDGLVDCMDPDCCLQSSCQTQPFCRGSPDPIDIISQNQPASPQQAAQSFYQQISFLTGPESTHVINGENPFNRSLVSIIRGQVLTADGTPLIGVNVSFVHYPDHGYTITRQDGMFDILANGGASLTLSFERAPFLTQFRTVWIPWNVFYVMDTLVMKKEENDIPSCDLSGFIRPSPLIVATPLSTFFRSSPENGPIIPETQVLQEETAIPGSDLNLMYLSSRAAGYRPVLKVTMTQATIPFNLMKVHLMVAVVGRLFQKWFPAEPNLSYTFIWDKTDAYNQRVYGLSEAVVSVGFEYESCLDLILWEKRTAILQGYELDASNMGGWTLDKHHVLDVQNGILYKGNGENVFVSQQPPVISTIMGNGRRRSISCPSCNGQADGNKLLAPVALACGSDGSLFVGDFNYIRRIFPSGNVTSVMELSNNPAHRYYLATDPMTGQLYVSDTNSRRIFRPKALTGTKELLQNAEVVAGTGEQCLPFDEARCGDGGKATEALLLGPKGIAVDKNGFIYFVDGTMIRKVDRNGIISTLLGSNDLTSARPLTCDNSMHIGQVRLEWPTDLAINPMDNSIYVLDNNVVLQITENRQVRIVAGRPMHCQVPGIEYTMGKRAIQTTLEGATAISLSYSGVLYIAETDEKKINRIRQVSTDGEISHLAGAPSDCDCKNDANCDCYQTGDGYAKDARLNAPSSLVVSPDGTLYVADLGNIRIRAIRHNRPPQGSSGLFEVASPASQELYVFDSNGTHQYTMSLVTGDYKYNFSYSNEDDVTAVTDSSGNTLRVRRDPNRMPVRIVAPDNQVIWLTIGTNGGLKTLTAQGQELVLFTYHGNSGLLATKSIQIGWTTFYDYDSEGRLTNVTFPTGVITSLIGEMDRALTVDIETSGRDDDVSITTNLSSIDSFYTLVQDQLRNSYQVGYDNSMRVIYANGMDSHFQTEPHILAGASNPTVARRNMTLPGENGQNLVEWRFRKEQNRGKVVVFGRKLRVNGRNLLSVDYDRSLRTEKIYDDHRKFLLKIVYDASGHPTLWVPSSKLMSVNLTYSSTGQVTSLQRGPTTERVEYDSQGRIVSRTFADAKIWSYTYLDKSMVLLLHSQRQYIFDYDLQDRLSAITMPSVARHTMQTIRSVGYYRNIYNPPESNASVTVDYSEDGQLLRVAHLGTGRRVLYKYRRQNKLSEILYDSTRVSFTYDETAGVLKTVNLQSEGFICSIRYRQIGPLVDRQIFRFSEDGMVNARFDYTYDNSFRVTSMQGVINETPLPIDLYQFDDISGKVEQFGKFGVIYYDINQIISTAVMTYTKHFDVHGRIKEIQYEIFRSLMYWITIQYDNMGRVTKREIKIGPFANTTKYGYEYDVDGQLQTVYLNEKMMWRYNYDLNGNLHLLNPGNSARLTPLRYDLRDRITRLGDVQYRMDEDGFLRQRGAEIFEYNSKGLLVRVHSKASGWTIQYRYDGLGRRLASRNSLGQHLQFFYADLNYPTRITHVYNHSSSEITSLYYDLQGHLFAMEISSGEEFYIACDNTGTPLAVFSSNGLLLKQVQYTAYGEIYFDSNPDFQLVIGFHGGLYDPLTRLLHFGERDYDIQAGRWTTPDISTWTRVGKDPAPFNLYMFRNNNPISKIHEVKEYVTDVNIWLVTFGFHLHNVIPGFPIPKFDLTQPSLEMRKSQLWDDLPSISGVQQEVMRQAKAFLSFERMPEIQLSRRRSSREKPWLWFATVKSLIGKGVMLAITSKGQVATNALNIANEDCIKVATVLNNAFYLEDLHFTVEGRDTHYFIKTSLPESDLGALRLTSGRKSLENGVNVTVSQSTTVVNGRTRRFADVELQYGALALHVRYGMTLDEEKARVLEQARQRALSSAWAREQQRVRDGEEGVRLWTEGEKRQLLSSGKVLGYDGYYVLSVEQYPELADSANNVQFLRQSEIGKR

Q9W7R4-2

  • Name
    2
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
Q0D280Q0D280_DANREtenm3189

Features

Showing features for compositional bias, alternative sequence, sequence conflict.

TypeIDPosition(s)Description
Compositional bias1-28Basic and acidic residues
Alternative sequenceVSP_0595631-104in isoform 2
Compositional bias30-45Polar residues
Compositional bias163-182Polar residues
Sequence conflict781in Ref. 1; BAA81892
Sequence conflict813in Ref. 1; BAA81892
Sequence conflict892in Ref. 1; BAA81892
Sequence conflict1210in Ref. 1; BAA81892
Sequence conflict1880-1884in Ref. 1; BAA81892
Sequence conflict2520in Ref. 1; BAA81892

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AB026979
EMBL· GenBank· DDBJ
BAA81892.1
EMBL· GenBank· DDBJ
mRNA
BX005481
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
BX322797
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
BX324137
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
BX324208
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.

Genome annotation databases

Similar Proteins

Disclaimer

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