Q9W708 · Q9W708_XENLA
- ProteinDelta(14)-sterol reductase LBR
- Genelbr.S
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids620 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score4/5
Function
function
Catalyzes the reduction of the C14-unsaturated bond of lanosterol, as part of the metabolic pathway leading to cholesterol biosynthesis.
Catalytic activity
- 4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + NADP+ = 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + NADPH + H+
- 4,4-dimethyl-8,14-cholestadien-3beta-ol + NADPH + H+ = 4,4-dimethyl-5alpha-cholest-8-en-3beta-ol + NADP+
- 5alpha-cholest-8,14-dien-3beta-ol + NADPH + H+ = 5alpha-cholest-8-en-3beta-ol + NADP+
Pathway
Steroid biosynthesis; cholesterol biosynthesis.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | endoplasmic reticulum membrane | |
Cellular Component | nuclear inner membrane | |
Molecular Function | delta14-sterol reductase activity | |
Molecular Function | DNA binding | |
Biological Process | cholesterol biosynthetic process |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameDelta(14)-sterol reductase LBR
- EC number
- Short namesC14SR ; Delta-14-SR
- Alternative names
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Amphibia > Batrachia > Anura > Pipoidea > Pipidae > Xenopodinae > Xenopus > Xenopus
Accessions
- Primary accessionQ9W708
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Endoplasmic reticulum membrane ; Multi-pass membrane protein
Nucleus inner membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Transmembrane | 217-239 | Helical | |||
Transmembrane | 259-278 | Helical | |||
Transmembrane | 299-318 | Helical | |||
Transmembrane | 330-350 | Helical | |||
Transmembrane | 390-411 | Helical | |||
Transmembrane | 452-471 | Helical | |||
Transmembrane | 491-509 | Helical | |||
Transmembrane | 560-586 | Helical | |||
Keywords
- Cellular component
PTM/Processing
Expression
Gene expression databases
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 8-66 | Tudor | |||
Region | 60-121 | Disordered | |||
Compositional bias | 69-93 | Basic residues | |||
Sequence similarities
Belongs to the ERG4/ERG24 family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length620
- Mass (Da)71,129
- Last updated1999-11-01 v1
- ChecksumB70179E01F57C5EA
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 69-93 | Basic residues | |||
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
Y17842 EMBL· GenBank· DDBJ | CAB44317.1 EMBL· GenBank· DDBJ | mRNA |