Q9W708 · Q9W708_XENLA

Function

function

Catalyzes the reduction of the C14-unsaturated bond of lanosterol, as part of the metabolic pathway leading to cholesterol biosynthesis.

Catalytic activity

Pathway

Steroid biosynthesis; cholesterol biosynthesis.

GO annotations

AspectTerm
Cellular Componentendoplasmic reticulum membrane
Cellular Componentnuclear inner membrane
Molecular Functiondelta14-sterol reductase activity
Molecular FunctionDNA binding
Biological Processcholesterol biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Delta(14)-sterol reductase LBR
  • EC number
  • Short names
    C14SR
    ; Delta-14-SR
  • Alternative names
    • 3-beta-hydroxysterol Delta (14)-reductase
    • C-14 sterol reductase
    • Integral nuclear envelope inner membrane protein
    • Lamin-B receptor
    • Sterol C14-reductase

Gene names

    • Name
      lbr.S
    • Synonyms
      dhcr14b
      , lbr
      , lbr-A
      , lmn2r
      , p58 gene
      , Xp58

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Amphibia > Batrachia > Anura > Pipoidea > Pipidae > Xenopodinae > Xenopus > Xenopus

Accessions

  • Primary accession
    Q9W708

Proteomes

Organism-specific databases

Subcellular Location

Cytoplasm
Endoplasmic reticulum membrane
; Multi-pass membrane protein
Nucleus inner membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane217-239Helical
Transmembrane259-278Helical
Transmembrane299-318Helical
Transmembrane330-350Helical
Transmembrane390-411Helical
Transmembrane452-471Helical
Transmembrane491-509Helical
Transmembrane560-586Helical

Keywords

PTM/Processing

Keywords

Proteomic databases

Expression

Gene expression databases

    • 378609Expressed in spleen and 18 other cell types or tissues

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain, region, compositional bias.

Type
IDPosition(s)Description
Domain8-66Tudor
Region60-121Disordered
Compositional bias69-93Basic residues

Sequence similarities

Belongs to the ERG4/ERG24 family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    620
  • Mass (Da)
    71,129
  • Last updated
    1999-11-01 v1
  • Checksum
    B70179E01F57C5EA
MIKKMPGQKYEIGETVMGRWPGSSLYYEVQVVGFNSKSQEYKVLYKDGTDLDLKEGDIKRQNIFNRKRSSSPSRRRSRSRSRSPGRSRSPARRRSPLRPSSPGRPAKNGHQSSLIRDIKKGDTLQVHLTPVKLQDYSTGKHNGEPEGFEKITTRHRATPVKAIELMEEELERNEKVLHYSLSPRQESSIPTGIVLADSVPTETLPEMTEKNAENPKLAFGGAIGCFLFMVCVPALLYYLLVVCGQQYTSGYPFVELLDIQVFGFFVLWTLLQVILYLLPLGKVVDGAQLKNGKRLKYRISGCSAFFLTAAIMAGMKYYYEINFLYIFEHYLQFAASATLFSFLLSIYLYVRSYKVPNEELSWAANSGNFIYKFVMGREINPRIGNLDLKVFVVIRQALMSWVLINLIMLFAEMKVHKWDEPSLSMILVNSFQLLYVLDGFWNEEYFLMSPDIVRDGFGFLLAFGSLAVAPFTYSLQTYYLVNNPVDLSRQAASAIVALKFLGYIIYRGANNQKCAFRQNPDDPRLSHLKTIPTSAGSKLLISGWWGFVRHPNYLGDIIMALAWCLACGFNHILPYFYVIFLTLLLIDRAARDEQRCREKYGLDWDKYCQHVRYRLLPYVY

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias69-93Basic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
Y17842
EMBL· GenBank· DDBJ
CAB44317.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

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