The RNA-binding properties of SMN: deletion analysis of the zebrafish orthologue defines domains conserved in evolution.Bertrandy S., Burlet P., Clermont O., Huber C., Fondrat C., Thierry-Mieg D., Munnich A., Lefebvre S.View abstractCited forNUCLEOTIDE SEQUENCE [MRNA]CategoriesSequencesSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCHum. Mol. Genet. 8:775-782 (1999)Cited in11
Online automated in vivo zebrafish phosphoproteomics: from large-scale analysis down to a single embryo.Lemeer S., Pinkse M.W.H., Mohammed S., van Breukelen B., den Hertog J., Slijper M., Heck A.J.R.View abstractCited forPHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-14; SER-17 AND SER-20, IDENTIFICATION BY MASS SPECTROMETRYTissueEmbryoCategoriesPTM / Processing, SequencesSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCJ. Proteome Res. 7:1555-1564 (2008)Cited in8622
An SMN-dependent U12 splicing event essential for motor circuit function.Lotti F., Imlach W.L., Saieva L., Beck E.S., Hao le T., Li D.K., Jiao W., Mentis G.Z., Beattie C.E.[...], Pellizzoni L.View abstractCited forFUNCTION, DISRUPTION PHENOTYPECategoriesFunction, Phenotypes & VariantsSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCCell 151:440-454 (2012)Cited in71Mapped to59
HuD and the Survival Motor Neuron Protein Interact in Motoneurons and Are Essential for Motoneuron Development, Function, and mRNA Regulation.Hao le T., Duy P.Q., An M., Talbot J., Iyer C.C., Wolman M., Beattie C.E.View abstractCited forFUNCTION, INTERACTION WITH ELAVL4, DISRUPTION PHENOTYPECategoriesFunction, Interaction, Phenotypes & VariantsSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCJ. Neurosci. 37:11559-11571 (2017)Cited in41Mapped to7
Fluorescence Correlation Spectroscopy Reveals Survival Motor Neuron Oligomerization but No Active Transport in Motor Axons of a Zebrafish Model for Spinal Muscular Atrophy.Koh A., Sarusie M.V., Ohmer J., Fischer U., Winkler C., Wohland T.View abstractSourceZFIN: ZDB-GENE-990715-16PubMedEurope PMCFront Cell Dev Biol 9:639904-639904 (2021)Mapped to1
Sumoylation regulates the assembly and activity of the SMN complex.Riboldi G.M., Faravelli I., Kuwajima T., Delestree N., Dermentzaki G., De Planell-Saguer M., Rinchetti P., Hao L.T., Beattie C.C.[...], Lotti F.View abstractSourceZFIN: ZDB-GENE-990715-16PubMedEurope PMCNat Commun 12:5040-5040 (2021)Mapped to40
A novel zebrafish model for intermediate type spinal muscular atrophy demonstrates importance of Smn for maintenance of mature motor neurons.Tay S.H., Ellieyana E.N., Le Y., Sarusie M.V., Grimm C., Ohmer J., Mathuru A.S., Fischer U., Winkler C.View abstractCategoriesPhenotypes & VariantsSourceZFIN: ZDB-GENE-990715-16PubMedEurope PMCHum Mol Genet 30:2488-2502 (2021)Mapped to1
A subset of SMN complex members have a specific role in tissue regeneration via ERBB pathway-mediated proliferation.Pei W., Xu L., Chen Z., Slevin C.C., Pettie K.P., Wincovitch S., Burgess S.M., Barnabas B.B., Black S.[...], Young A.C.View abstractCategoriesNames, FunctionSourceZFIN: ZDB-GENE-990715-16PubMedEurope PMCNPJ Regen Med 5:6-6 (2020)Mapped to27
Guided genetic screen to identify genes essential in the regeneration of hair cells and other tissues.Pei W., Xu L., Huang S.C., Pettie K., Idol J., Rissone A., Jimenez E., Sinclair J.W., Slevin C.[...], Burgess S.M.View abstractCategoriesPhenotypes & VariantsSourceZFIN: ZDB-GENE-990715-16PubMedEurope PMCNPJ Regen Med 3:11-11 (2018)Cited in10Mapped to23
Bioenergetic status modulates motor neuron vulnerability and pathogenesis in a zebrafish model of spinal muscular atrophy.Boyd P.J., Tu W.Y., Shorrock H.K., Groen E.J.N., Carter R.N., Powis R.A., Thomson S.R., Thomson D., Graham L.C.[...], Gillingwater T.H.View abstractCategoriesPhenotypes & VariantsSourceZFIN: ZDB-GENE-990715-16PubMedEurope PMCPLoS Genet 13:e1006744-e1006744 (2017)Cited in1Mapped to13
Neurocalcin Delta Suppression Protects against Spinal Muscular Atrophy in Humans and across Species by Restoring Impaired Endocytosis.Riessland M., Kaczmarek A., Schneider S., Swoboda K.J., Lohr H., Bradler C., Grysko V., Dimitriadi M., Hosseinibarkooie S.[...], Wirth B.View abstractCategoriesPhenotypes & VariantsSourceZFIN: ZDB-GENE-990715-16PubMedEurope PMCAm J Hum Genet 100:297-315 (2017)Mapped to18
Systemic restoration of UBA1 ameliorates disease in spinal muscular atrophy.Powis R.A., Karyka E., Boyd P., Come J., Jones R.A., Zheng Y., Szunyogova E., Groen E.J., Hunter G.[...], Gillingwater T.H.View abstractCategoriesPhenotypes & VariantsSourceZFIN: ZDB-GENE-990715-16PubMedEurope PMCJCI Insight 1:e87908-e87908 (2016)Mapped to10
The Power of Human Protective Modifiers: PLS3 and CORO1C Unravel Impaired Endocytosis in Spinal Muscular Atrophy and Rescue SMA Phenotype.Hosseinibarkooie S., Peters M., Torres-Benito L., Rastetter R.H., Hupperich K., Hoffmann A., Mendoza-Ferreira N., Kaczmarek A., Janzen E.[...], Wirth B.View abstractCategoriesPhenotypes & VariantsSourceZFIN: ZDB-GENE-990715-16PubMedEurope PMCAm J Hum Genet 99:647-665 (2016)Mapped to25
alpha-COP binding to the survival motor neuron protein SMN is required for neuronal process outgrowth.Li H., Custer S.K., Gilson T., Hao l.e. T., Beattie C.E., Androphy E.J.View abstractCategoriesFunction, Phenotypes & VariantsSourceZFIN: ZDB-GENE-990715-16PubMedEurope PMCHum Mol Genet 24:7295-7307 (2015)Mapped to1
Plastin 3 Expression Does Not Modify Spinal Muscular Atrophy Severity in the ∆7 SMA Mouse.McGovern V.L., Massoni-Laporte A., Wang X., Le T.T., Le H.T., Beattie C.E., Rich M.M., Burghes A.H.View abstractCategoriesPhenotypes & VariantsSourceZFIN: ZDB-GENE-990715-16PubMedEurope PMCPLoS One 10:e0132364-e0132364 (2015)Mapped to32
Effective heritable gene knockdown in zebrafish using synthetic microRNAs.Giacomotto J., Rinkwitz S., Becker T.S.View abstractCategoriesFunction, Phenotypes & VariantsSourceZFIN: ZDB-GENE-990715-16PubMedEurope PMCNat Commun 6:7378-7378 (2015)Mapped to1
Non-aggregating tau phosphorylation by cyclin-dependent kinase 5 contributes to motor neuron degeneration in spinal muscular atrophy.Miller N., Feng Z., Edens B.M., Yang B., Shi H., Sze C.C., Hong B.T., Su S.C., Cantu J.A.[...], Ma Y.C.View abstractCategoriesPhenotypes & VariantsSourceZFIN: ZDB-GENE-990715-16PubMedEurope PMCJ Neurosci 35:6038-6050 (2015)Mapped to39
Motoneuron development influences dorsal root ganglia survival and Schwann cell development in a vertebrate model of spinal muscular atrophy.Hao l.e. T., Duy P.Q., Jontes J.D., Beattie C.E.View abstractCategoriesPhenotypes & VariantsSourceZFIN: ZDB-GENE-990715-16PubMedEurope PMCHum Mol Genet 24:346-360 (2015)Mapped to1
Yeast Augmented Network Analysis (YANA): a new systems approach to identify therapeutic targets for human genetic diseases.Wiley D.J., Juan I., Le H., Cai X., Baumbach L., Beattie C., D'Urso G.View abstractCategoriesPhenotypes & VariantsSourceZFIN: ZDB-GENE-990715-16PubMedEurope PMCF1000Res 3:121-121 (2014)Mapped to1
Dysregulation of ubiquitin homeostasis and beta-catenin signaling promote spinal muscular atrophy.Wishart T.M., Mutsaers C.A., Riessland M., Reimer M.M., Hunter G., Hannam M.L., Eaton S.L., Fuller H.R., Roche S.L.[...], Gillingwater T.H.View abstractCategoriesPhenotypes & VariantsSourceZFIN: ZDB-GENE-990715-16PubMedEurope PMCJ Clin Invest 124:1821-1834 (2014)Cited in1Mapped to36
Calcium binding is essential for plastin 3 function in Smn-deficient motoneurons.Lyon A.N., Pineda R.H., Hao l.e. T., Kudryashova E., Kudryashov D.S., Beattie C.E.View abstractCategoriesPhenotypes & VariantsSourceZFIN: ZDB-GENE-990715-16PubMedEurope PMCHum Mol Genet 23:1990-2004 (2014)Cited in1Mapped to9
SMN deficiency alters Nrxn2 expression and splicing in zebrafish and mouse models of spinal muscular atrophy.See K., Yadav P., Giegerich M., Cheong P.S., Graf M., Vyas H., Lee S.G., Mathavan S., Fischer U.[...], Winkler C.View abstractCategoriesPhenotypes & VariantsSourceZFIN: ZDB-GENE-990715-16PubMedEurope PMCHum Mol Genet 23:1754-1770 (2014)Cited in16Mapped to38
Chondrolectin affects cell survival and neuronal outgrowth in in vitro and in vivo models of spinal muscular atrophy.Sleigh J.N., Barreiro-Iglesias A., Oliver P.L., Biba A., Becker T., Davies K.E., Becker C.G., Talbot K.View abstractCategoriesPhenotypes & VariantsSourceZFIN: ZDB-GENE-990715-16PubMedEurope PMCHum. Mol. Genet. 23:855-869 (2014)Cited in2Mapped to12
Temporal requirement for SMN in motoneuron development.Hao l.e. T., Duy P.Q., Jontes J.D., Wolman M., Granato M., Beattie C.E.View abstractCategoriesPhenotypes & VariantsSourceZFIN: ZDB-GENE-990715-16PubMedEurope PMCHum Mol Genet 22:2612-2625 (2013)Mapped to1
EPHA4 is a disease modifier of amyotrophic lateral sclerosis in animal models and in humans.Van Hoecke A., Schoonaert L., Lemmens R., Timmers M., Staats K.A., Laird A.S., Peeters E., Philips T., Goris A.[...], Robberecht W.View abstractCategoriesPhenotypes & VariantsSourceZFIN: ZDB-GENE-990715-16PubMedEurope PMCNat Med 18:1418-1422 (2012)Mapped to20