Q9W6C3 · Q9W6C3_9ANUR
- ProteinProopiomelanocortin
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids258 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score2/5
Function
function
Endogenous opiate.
Stimulates the adrenal glands to release cortisol.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | extracellular space | |
Cellular Component | secretory granule | |
Molecular Function | G protein-coupled receptor binding | |
Molecular Function | hormone activity | |
Biological Process | neuropeptide signaling pathway | |
Biological Process | regulation of corticosterone secretion |
Keywords
- Molecular function
Names & Taxonomy
Protein names
- Submitted names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Amphibia > Batrachia > Anura > Pelobatoidea > Pelobatidae > Spea
Accessions
- Primary accessionQ9W6C3
Subcellular Location
PTM/Processing
Features
Showing features for signal, chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-25 | |||||
Sequence: MLCPVWSCLFAVLGVFVFHVGEVRG | ||||||
Chain | PRO_5004335786 | 26-258 | ||||
Sequence: QCWQSAKCMDLESEDGILECIKACKTDLSAESPIFPGNGHLQPLAENVRKYVMSHFRWNKFGRRNTTGNEGNSGSKREDIANYPIFNLFPSSNGQNTEDNMWKKYQDRQDNKRSYSMEHFRWGKPVGRKRRPIKVFPNGMEEESSESYPMELRRELSLEDDYPEIDSEDDLDYNDLLSMPKFKGGDYRIHHFRWGSPPKDKRYGGFMTPERSQTPLMTLFKNAIIKNAHKKAQ |
Keywords
- PTM
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 26-70 | Pro-opiomelanocortin N-terminal | ||||
Sequence: QCWQSAKCMDLESEDGILECIKACKTDLSAESPIFPGNGHLQPLA | ||||||
Domain | 75-112 | Pro-opiomelanocortin/corticotropin ACTH central region | ||||
Sequence: KYVMSHFRWNKFGRRNTTGNEGNSGSKREDIANYPIFN | ||||||
Domain | 139-177 | Pro-opiomelanocortin/corticotropin ACTH central region | ||||
Sequence: SYSMEHFRWGKPVGRKRRPIKVFPNGMEEESSESYPMEL | ||||||
Domain | 211-249 | Pro-opiomelanocortin/corticotropin ACTH central region | ||||
Sequence: DYRIHHFRWGSPPKDKRYGGFMTPERSQTPLMTLFKNAI | ||||||
Domain | 228-256 | Opiodes neuropeptide | ||||
Sequence: YGGFMTPERSQTPLMTLFKNAIIKNAHKK |
Sequence similarities
Belongs to the POMC family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length258
- Mass (Da)29,978
- Last updated1999-11-01 v1
- Checksum1BC8BD3071A00C36