Q9W4E2 · NBEA_DROME

Function

function

Binds to type II regulatory subunits of protein kinase A and anchors/targets them to the membrane. May anchor the kinase to cytoskeletal and/or organelle-associated proteins. Required for correct retinal pattern formation and may function in cell fate determination through its interactions with the EGFR and Notch signaling pathways. Required for associative odor learning and short-term memory. Involved in development of the neuromuscular junction and the mushroom body.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytoplasm
Cellular Componentcytosol
Cellular Componentmembrane
Cellular Componentneuronal cell body
Cellular Componentperikaryon
Molecular Functionprotein kinase A binding
Molecular Functionprotein kinase binding
Biological Processcompound eye cone cell differentiation
Biological Processeye photoreceptor cell development
Biological Processmushroom body development
Biological Processneuromuscular junction development
Biological Processolfactory learning
Biological Processprotein localization
Biological Processshort-term memory

Names & Taxonomy

Protein names

  • Recommended name
    Neurobeachin
  • Alternative names
    • A-kinase anchor protein 550 (AKAP 550)
    • Protein rugose
    • dAKAP550

Gene names

    • Name
      rg
    • Synonyms
      Akap550
    • ORF names
      CG44835

Organism names

  • Taxonomic identifier
  • Strains
    • Berkeley
    • Canton-S
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Brachycera > Muscomorpha > Ephydroidea > Drosophilidae > Drosophila > Sophophora

Accessions

  • Primary accession
    Q9W4E2
  • Secondary accessions
    • O16024
    • Q8IRR9
    • Q961G8
    • Q9GP69
    • Q9GP70

Proteomes

Organism-specific databases

Subcellular Location

Membrane ; Peripheral membrane protein
Note: Found in the cortical region of perikarya with no expression in neuropil regions. Located at or near the Golgi network in perikarya of the dorsal medial cluster neurons.

Keywords

Phenotypes & Variants

Disruption phenotype

Mutants are viable and fertile but display a rough eye surface phenotype, impaired short-term memory, aberrant associative odor learning, aberrant neuromuscular junction morphology with increased numbers of synaptic boutons, and defective axonal morphology of the Kenyon cells, the neurons of the mushroom body.

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00000510931-3466Neurobeachin

Proteomic databases

Expression

Tissue specificity

In early embryos, ubiquitous expression with elevated levels in ventral furrow and flanking mesectodermal cells, neuroblasts and mesoderm. Late embryos show reduced expression in epidermis and skeletal muscle and elevated in nervous system, gut endothelium, tracheal system and salivary gland. Larvae show expression in imaginal disks and many neural cells. Developing eye imaginal disk shows expression throughout the disk and in the region of the morphogenetic furrow. Ubiquitous expression in adults with higher levels in head region. Expressed in larval neurons but not in larval glia.

Developmental stage

All stages of development.

Gene expression databases

Interaction

Subunit

Interacts with RII subunit of PKA and components of the EGFR-mediated and Notch-mediated signaling pathways.

Protein-protein interaction databases

Structure

3D structure databases

Family & Domains

Features

Showing features for compositional bias, region, repeat, domain.

TypeIDPosition(s)Description
Compositional bias523-539Polar residues
Region523-565Disordered
Region1363-1382Disordered
Compositional bias1393-1441Polar residues
Region1393-1465Disordered
Region1545-1583Disordered
Compositional bias1558-1574Basic and acidic residues
Region1601-1695Disordered
Compositional bias1605-1691Basic and acidic residues
Compositional bias1716-1739Polar residues
Region1716-1767Disordered
Compositional bias1747-1767Polar residues
Compositional bias1794-1840Polar residues
Region1794-1848Disordered
Repeat1846-1888WD 1
Region2105-2130Disordered
Region2198-2257Disordered
Compositional bias2218-2236Polar residues
Compositional bias2240-2254Basic and acidic residues
Region2284-2365Disordered
Compositional bias2297-2316Polar residues
Domain2666-2774BEACH-type PH
Domain2793-3082BEACH
Repeat3241-3284WD 2
Repeat3298-3338WD 3
Repeat3380-3419WD 4
Repeat3422-3461WD 5

Domain

RII-alpha binding site, predicted to form an amphipathic helix, could participate in protein-protein interactions with a complementary surface on the R-subunit dimer.

Sequence similarities

Belongs to the WD repeat neurobeachin family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence & Isoform

Align isoforms (2)
  • Sequence status
    Complete

This entry describes 2 isoforms produced by Alternative splicing.

Q9W4E2-5

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Length
    3,466
  • Mass (Da)
    384,513
  • Last updated
    2016-03-16 v4
  • Checksum
    152AEB5152C8F37C
MADIMRPPYSEIKRPDEIVRMTTADNLKFAVLIGLIEVGQVTNREVVNTVLHLLVGGEFDMELNFVIQDAQNIKHMLELLDHCPPNLQAEIWSVFIAILRKSVRNLQACTDVGLIEHVLVRLQRSETVVADLLIEMLGVLASYSITVKELKLLFGTMKATNGKWPRHSAKLLNVLRQMPHRNGPDVFFSFPGRKGSAMVLPPLAKWPYENGFTFTTWFRLDPINSVNIEREKPYLYCFKTSKGVGYTAHFVGNCLVLTSMKVKGKGFQHCVKYEFQPRKWYMIAIVYIYNRWTKSEIKCLVNGQLASSTEMAWFVSTNDPFDKCYIGATPELDEERVFCGQMSAIYLFSEALTTQQICAMHRLGPGYKSQFRFDNECYLNLPDNHKRVSHFQLLPATLGASALSGGSGSGTGSGTGNDASAAAAAAVAAGQQQQLQLQFQILAAEQEARAIDWSDEKLDLNAAFVKIRAVLTARNAVTLAGSSSTGTTAVATAAAAAAAAGAGAGTTAAATSAAAAAAATQNENDAAVGQQQHATHHHATAATGSADDPLGHLPTGNASSSSSSFEQLRRMSSVSSLNSMVGSADTEEVNQLKAVLYDGKLSNAIVFMYNPVATDGQLCLQSSPKGNVSYFVHTPHALMLQDVKAVVTHSIHCTLNSIGGIQVLFPLFSQLDMAHEGLGDIKRDPTLCSKLLGFICELVETSQTVQQHMIQNRGFLVISFMLQRSSREHLTLEVLGSFLNLTKYLVTCLSANSDLLLKQLFCFSFLTWQLLDHVLFNPALWIYTPANVQARLYSYLATEFLSDTQIYSNVRRVSTVLQTVHTLKYYYWVVNPRAKSGIIPKGLDGPRPAQKDILAIRAYILLFLKQLIMIGNGVKEDELQSILNYLTTMHEDENLHDVLQMLISLMSEHPSSMVPAFDVKHGVRSIFKLLAAESQLIRLQALKLLGFFLSRSTHKRKYDVMSPHNLYTLLAERLLLYEESLSLPTYNVLYEIMTEHISQQILYTRHPEPESHYRLENPMILKVVATLIRQSKQTESLIDVKKLFLQDMTLLCNSNRENRRTVLQMSVWQEWLIAMAYIHPKSSEEQKISDMVYSLFRMLLHHAIKHEYGGWRVWVDTLAIVHSKVSYEEFKLQFAQMYEHYERQRTDNITDPALRQARPISTISGWEREELHQQQNGGSAAAVATNQTAAVKGSVSIASLEDVPPVVEEEVEELELEEVEIQEGPITEETEQKSVIANISDVYNEQLKTDATCNGNLEDVKEEEPVQQQIGDLEKQPEPSTPLGALRETLQLGDDMDVEELELATAKDALNAEQHVSRVLQASEAALNDCKMAVDDVLQESSSVLKDEEIELAVNEVVQGVLNNEKKTQSQDNKDNKEQPGEQDVNVSLLNSKNLLNNNNNNNNNSPSPTPTTATATAETEAETEVNANEIVSSTEAPKAETETSVAPEVETPETAKPSPIVPSPVLATNQKTEDAANKLNNNEKLAEISASPEPPIVVETPEADLLQLSDSETKPNKETEAEDSVALAVRDIVEQLIDKVIDATEAESASETKTETNNNEIPKKEKQTSEEPEDVETAETLAAAAKEIVQEVVEAALVMVQEESTQEKPEKGANSEEEKNEIGKEEILLQLEEKPASTEVQETKIEGDLKKPEDPKGHSSVEPKTPNLEEPKPQETEQQKSQEVAEELPQKPEEQVVAIVNQVLDTLVDDTVKAVAAEQTTQTSPAPEEQSPQILAMESPATSVRVKPTEVDSTTQTTPKNEAGSSLLVEQVQQVLQEDDAQQSAGMTIEDEDYSNQQAAAAVENANSSQLDANHYGPGNPESKQQQQRSKSGSTRPMFSPGPTRPPFRIPEFKWSYIHQRLLSDVLFSLETDIQVWRSHSTKSVLDFVNSSENAIFVVNTVHLISQLADNLIIACGGLLPLLASATSPNSELDVLEPTQGMPLEVAVSFLQRLVNMADVLIFATSLNFGELEAEKNMSSGGILRQCLRLVCTCAVRNCLECKERTRYNVGALARDVPGAAHLQALIRGAQASPKNIVESITGQLSPVKDPEKLLQDMDVNRLRAVIYRDVEETKQAQFLSLAIVYFISVLMVSKYRDILEPPAEPQIQRQSPVLQRTAGGGGRQIQDSDYEIIVVDENNPSVLADNDSHSSGPPSIKANQTTTIATTTTTTATTHINNNNTKTTTSNAPTATIKIQQQPLSPPKPLVPQKLPKSVDSDVGSLNMNSTENEVPEVESSSEILIDDHKPSHSNDESWTDVNLNEDAAVQAASAGIVVGLVDNRGNVISDKHDPSHHNQQQQQQAGIIGQQQQHGSLGHSERGDKPDSEISVVRVPDGYGGAGSGGGVNSGQGQGVPSNQRPRPEELPMKAPALVAQLPLTTPSREASLTQKLEIALGPVCPLLREIMVDFAPFLSKTLVGSHGQELLMEGKGLTTFKNSHSVVELVMLLCSQEWQNSLQKHAGLAFIELINEGRLLSHAMKDHIVRVANEAEFILNRMRADDVLKHADFESQCAQTLLERREEERMCDHLITAARRRDNVIASRLLEKVRNIMCNRHGAWGDSSSTSSGGAIVGAVQKSPYWKLDAWEDDARRRKRMVQNPRGSSHPQATLKAALENGGPEDAILQTRDEFHTQIAVSRTHPSGQHNGELLDDAELLIEDRELDLDLTGPVNISTKARLIAPGLVAPGTVSITSTEMFFEVDEEHPEFQKIDGEVLKYCDHLHGKWYFSEVRAIFSRRYLLQNVALEIFLASRTSILFAFPDQHTVKKVIKALPRVGVGIKYGIPQTRRASMMSPRQLMRNSNMTQKWQRREISNFEYLMFLNTIAGRTYNDLNQYPIFPWVLTNYESKDLDLSLPSNYRDLSKPIGALNPSRRAYFEERYESWDSDTIPPFHYGTHYSTAAFTLNWLVRVEPFTTMFLALQGGKFDYPDRLFSSVSLSWKNCQRDTSDVKELIPEWYFLPEMFYNSSGYRLGHREDGALVDDIELPPWAKSPEEFVRINRMALESEFVSCQLHQWIDLIFGYKQRGPEAIRATNVFYYLTYEGSVDLDGVLDPVMREAVENQIRNFGQTPSQLLMEPHPPRSSAMHLSPMMFSAMPEDLCQMLKFYQNSPVIHISANTYPQLSLPSVVTVTAGHQFAVNRWNCNYTASVQSPSYAESPQSPGSNQPLTIDPVLAVHGTNNNSNAASRRHLGDNFSQMLKIRSNCFVTTVDSRFLIACGFWDNSFRVFATETAKIVQIVFGHFGVVTCMARSECNITSDCYIASGSADCTVLLWHWNARTQSIVGEGDVPTPRATLTGHEQAVTSVVISAELGLVVSGSSNGPVLIHTTFGDLLRSLDPPAEFHSPELITMSREGFIVINYDKGNVAAYTINGKKLRHETHNDNLQCMLLSRDGEYLMTAGDRGIVEVWRTFNLAPLYAFPACNAGIRSLALTHDQKYLLAGLSTGSIIVFHIDFNRWHHEYQQRY

Q9W4E2-6

  • Name
    R
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical
    • 2-53: ADIMRPPYSEIKRPDEIVRMTTADNLKFAVLIGLIEVGQVTNREVVNTVLHL → DSLERLMRAAPLPRMLTSGVVATAAAAASAAAGKGMVSVGGGATAIAAGGGQQRALVHASLAAATVGRKGRHLTGTFCLTGDTMEGIIQCLVFLKAFS
    • 388-594: Missing
    • 759-768: Missing
    • 2159-2214: Missing

Computationally mapped potential isoform sequences

There are 5 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
X2JE60X2JE60_DROMErg3446
Q0KHV9Q0KHV9_DROMErg3719
X2JAH8X2JAH8_DROMErg3785
B7Z0W8B7Z0W8_DROMErg3203
B7Z0X3B7Z0X3_DROMErg3400

Sequence caution

The sequence AAB83959.1 differs from that shown. Reason: Miscellaneous discrepancy Intron retention. In addition to the intron retained at the N-terminus, there are other discrepancies towards the C-terminus.
The sequence AAK93020.1 differs from that shown. Reason: Erroneous initiation Truncated N-terminus.
The sequence CAC18799.1 differs from that shown. Reason: Miscellaneous discrepancy Intron retention. In addition, there are retained or missing exons which cannot be reconciled with any described isoform.
The sequence CAC18800.1 differs from that shown. Reason: Miscellaneous discrepancy Intron retention. In addition, there are retained or missing exons which cannot be reconciled with any described isoform.

Features

Showing features for alternative sequence, sequence conflict, compositional bias.

TypeIDPosition(s)Description
Alternative sequenceVSP_0581612-53in isoform R
Sequence conflict218in Ref. 3; CAC18799/CAC18800 and 4; AAB83959
Sequence conflict237in Ref. 3; CAC18799/CAC18800 and 4; AAB83959
Alternative sequenceVSP_058162388-594in isoform R
Sequence conflict411in Ref. 3; CAC18799 and 4; AAB83959
Sequence conflict415in Ref. 3; CAC18799 and 4; AAB83959
Compositional bias523-539Polar residues
Sequence conflict552in Ref. 3; CAC18799 and 4; AAB83959
Sequence conflict590in Ref. 3; CAC18799 and 4; AAB83959
Alternative sequenceVSP_058163759-768in isoform R
Compositional bias1393-1441Polar residues
Compositional bias1558-1574Basic and acidic residues
Compositional bias1605-1691Basic and acidic residues
Sequence conflict1702in Ref. 3; CAC18799/CAC18800 and 4; AAB83959
Compositional bias1716-1739Polar residues
Compositional bias1747-1767Polar residues
Compositional bias1794-1840Polar residues
Alternative sequenceVSP_0581642159-2214in isoform R
Compositional bias2218-2236Polar residues
Sequence conflict2230-2239in Ref. 3; CAC18799/CAC18800 and 4; AAB83959
Compositional bias2240-2254Basic and acidic residues
Compositional bias2297-2316Polar residues
Sequence conflict2576in Ref. 3; CAC18799/CAC18800

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AE014298
EMBL· GenBank· DDBJ
AAF46011.4
EMBL· GenBank· DDBJ
Genomic DNA
AE014298
EMBL· GenBank· DDBJ
AAN09135.1
EMBL· GenBank· DDBJ
Genomic DNA
Y18278
EMBL· GenBank· DDBJ
CAC18799.1
EMBL· GenBank· DDBJ
mRNA Sequence problems.
Y18278
EMBL· GenBank· DDBJ
CAC18800.1
EMBL· GenBank· DDBJ
mRNA Sequence problems.
AF003622
EMBL· GenBank· DDBJ
AAB83959.1
EMBL· GenBank· DDBJ
mRNA Sequence problems.
AY051596
EMBL· GenBank· DDBJ
AAK93020.1
EMBL· GenBank· DDBJ
mRNA Different initiation

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp