Q9W3W4 · Q9W3W4_DROME
- Protein5-demethoxyubiquinone hydroxylase, mitochondrial
- GeneCoq7
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids219 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score4/5
Function
function
Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis. Has also a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides. Involved in lifespan determination in a ubiquinone-independent manner.
Catalytic activity
- a 6-methoxy-3-methyl-2-all-trans-polyprenyl-1,4-benzoquinol + AH2 + O2 = A + a 3-demethylubiquinol + H2O
a 6-methoxy-3-methyl-2-all-trans-polyprenyl-1,4-benzoquinol RHEA-COMP:10859 + CHEBI:17499 + CHEBI:15379 = CHEBI:13193 + a 3-demethylubiquinol RHEA-COMP:10914 + CHEBI:15377
Cofactor
Note: Binds 2 iron ions per subunit.
Pathway
Cofactor biosynthesis; ubiquinone biosynthesis.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 63 | Fe cation 1 (UniProtKB | ChEBI) | ||||
Sequence: E | ||||||
Binding site | 93 | Fe cation 2 (UniProtKB | ChEBI) | ||||
Sequence: E | ||||||
Binding site | 93 | Fe cation 1 (UniProtKB | ChEBI) | ||||
Sequence: E | ||||||
Binding site | 96 | Fe cation 1 (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Binding site | 145 | Fe cation 2 (UniProtKB | ChEBI) | ||||
Sequence: E | ||||||
Binding site | 180 | Fe cation 2 (UniProtKB | ChEBI) | ||||
Sequence: E | ||||||
Binding site | 180 | Fe cation 1 (UniProtKB | ChEBI) | ||||
Sequence: E | ||||||
Binding site | 183 | Fe cation 2 (UniProtKB | ChEBI) | ||||
Sequence: H |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | extrinsic component of mitochondrial inner membrane | |
Cellular Component | mitochondrial inner membrane | |
Cellular Component | nucleus | |
Cellular Component | ubiquinone biosynthesis complex | |
Molecular Function | 3-demethoxyubiquinol 3-hydroxylase activity | |
Molecular Function | metal ion binding | |
Molecular Function | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen | |
Biological Process | determination of adult lifespan | |
Biological Process | regulation of gene expression | |
Biological Process | regulation of reactive oxygen species metabolic process | |
Biological Process | ubiquinone biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended name5-demethoxyubiquinone hydroxylase, mitochondrial
- EC number
- Short namesDMQ hydroxylase
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Brachycera > Muscomorpha > Ephydroidea > Drosophilidae > Drosophila > Sophophora
Accessions
- Primary accessionQ9W3W4
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Mitochondrion inner membrane ; Peripheral membrane protein
Keywords
- Cellular component
PTM/Processing
Proteomic databases
Expression
Gene expression databases
Structure
Family & Domains
Features
Showing features for region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-51 | Disordered | ||||
Sequence: MNGMLRRGLSRPEPRLLSKRYLSSATGGGSAGTTEGGSSETTPLRPRPNAL | ||||||
Compositional bias | 23-46 | Polar residues | ||||
Sequence: SSATGGGSAGTTEGGSSETTPLRP |
Sequence similarities
Belongs to the COQ7 family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length219
- Mass (Da)24,072
- Last updated2002-10-01 v2
- Checksum4BB8AEAF33631B30
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 23-46 | Polar residues | ||||
Sequence: SSATGGGSAGTTEGGSSETTPLRP |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AE014298 EMBL· GenBank· DDBJ | AAF46199.2 EMBL· GenBank· DDBJ | Genomic DNA | ||
BT031015 EMBL· GenBank· DDBJ | ABV82397.1 EMBL· GenBank· DDBJ | mRNA |