Q9W3W4 · Q9W3W4_DROME

Function

function

Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis. Has also a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides. Involved in lifespan determination in a ubiquinone-independent manner.

Catalytic activity

Cofactor

Fe cation (UniProtKB | Rhea| CHEBI:24875 )

Note: Binds 2 iron ions per subunit.

Pathway

Cofactor biosynthesis; ubiquinone biosynthesis.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site63Fe cation 1 (UniProtKB | ChEBI)
Binding site93Fe cation 2 (UniProtKB | ChEBI)
Binding site93Fe cation 1 (UniProtKB | ChEBI)
Binding site96Fe cation 1 (UniProtKB | ChEBI)
Binding site145Fe cation 2 (UniProtKB | ChEBI)
Binding site180Fe cation 2 (UniProtKB | ChEBI)
Binding site180Fe cation 1 (UniProtKB | ChEBI)
Binding site183Fe cation 2 (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentextrinsic component of mitochondrial inner membrane
Cellular Componentmitochondrial inner membrane
Cellular Componentnucleus
Cellular Componentubiquinone biosynthesis complex
Molecular Function3-demethoxyubiquinol 3-hydroxylase activity
Molecular Functionmetal ion binding
Molecular Functionoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
Biological Processdetermination of adult lifespan
Biological Processregulation of gene expression
Biological Processregulation of reactive oxygen species metabolic process
Biological Processubiquinone biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    5-demethoxyubiquinone hydroxylase, mitochondrial
  • EC number
  • Short names
    DMQ hydroxylase
  • Alternative names
    • Ubiquinone biosynthesis monooxygenase COQ7

Gene names

    • Name
      Coq7
    • Synonyms
      COQ7
      , Dclk1
      , Dmel\CG14437
    • ORF names
      CG14437
      , Dmel_CG14437

Organism names

  • Taxonomic identifier
  • Strain
    • Berkeley
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Brachycera > Muscomorpha > Ephydroidea > Drosophilidae > Drosophila > Sophophora

Accessions

  • Primary accession
    Q9W3W4

Proteomes

Organism-specific databases

Subcellular Location

Keywords

PTM/Processing

Proteomic databases

Expression

Gene expression databases

Interaction

Subunit

Component of a multi-subunit COQ enzyme complex.

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for region, compositional bias.

TypeIDPosition(s)Description
Region1-51Disordered
Compositional bias23-46Polar residues

Sequence similarities

Belongs to the COQ7 family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    219
  • Mass (Da)
    24,072
  • Last updated
    2002-10-01 v2
  • Checksum
    4BB8AEAF33631B30
MNGMLRRGLSRPEPRLLSKRYLSSATGGGSAGTTEGGSSETTPLRPRPNALTDEIIRVDHAGELGADRIYAGQMAILGNGPLGKTIGHMWEQEKEHRKQFEQLIQQHRVRPTIMTPIWNVAGFVLGAGTALMGEKAAMACTVAVETVIVEHYNDQLRQIMEAPNPDKELLATITKFRDEEQEHHDTGIDHGAEQAPFYQAMTEVIKFGCKTAIAISKKI

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias23-46Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AE014298
EMBL· GenBank· DDBJ
AAF46199.2
EMBL· GenBank· DDBJ
Genomic DNA
BT031015
EMBL· GenBank· DDBJ
ABV82397.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

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