Q9W157 · BRCA2_DROME
- ProteinBreast cancer type 2 susceptibility protein homolog
- GeneBrca2
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids971 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Involved in and required for double-strand break repair by meiotic and mitotic homologous recombination. During meiosis, has a dual role in the repair of meiotic double-stranded breaks and the efficient activation of the meiotic recombination checkpoint.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | nucleus | |
Biological Process | cell division | |
Biological Process | DNA repair | |
Biological Process | DNA synthesis involved in double-strand break repair via homologous recombination | |
Biological Process | double-strand break repair via homologous recombination | |
Biological Process | meiotic DNA repair synthesis involved in reciprocal meiotic recombination | |
Biological Process | meiotic recombination checkpoint signaling | |
Biological Process | response to camptothecin |
Keywords
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameBreast cancer type 2 susceptibility protein homolog
- Short namesdmbrca2
Gene names
Organism names
- Strains
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Brachycera > Muscomorpha > Ephydroidea > Drosophilidae > Drosophila > Sophophora
Accessions
- Primary accessionQ9W157
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Note: Brca2 and spn-A/Rad51 become recruited to nuclear foci after DNA damage.
Keywords
- Cellular component
Phenotypes & Variants
Disruption phenotype
Induced sensitivity to DNA damage induced by irradiation or treatment with hydroxyurea/ Repair by homologous recombination is dramatically decreased. Instead, large flanking deletions are formed, and repair by the non-conservative single-strand annealing pathway predominates.
Features
Showing features for natural variant.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Natural variant | 242 | in strain: Zimbabwe30 | |||
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 1 variant from UniProt as well as other sources including ClinVar and dbSNP.
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000392916 | 1-971 | Breast cancer type 2 susceptibility protein homolog | ||
Proteomic databases
Expression
Gene expression databases
Structure
Family & Domains
Features
Showing features for region, compositional bias, repeat.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Region | 1-30 | Disordered | |||
Region | 130-155 | Disordered | |||
Compositional bias | 349-366 | Basic and acidic residues | |||
Region | 349-395 | Disordered | |||
Compositional bias | 367-395 | Polar residues | |||
Compositional bias | 420-441 | Polar residues | |||
Region | 420-466 | Disordered | |||
Repeat | 570-604 | BRCA2 1 | |||
Repeat | 671-705 | BRCA2 2 | |||
Repeat | 746-780 | BRCA2 3 | |||
Compositional bias | 916-932 | Polar residues | |||
Region | 916-971 | Disordered | |||
Compositional bias | 933-947 | Basic and acidic residues | |||
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length971
- Mass (Da)108,649
- Last updated2007-11-13 v3
- Checksum9232DE2A667672CE
Sequence caution
Features
Showing features for compositional bias, sequence conflict.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 349-366 | Basic and acidic residues | |||
Compositional bias | 367-395 | Polar residues | |||
Compositional bias | 420-441 | Polar residues | |||
Sequence conflict | 502 | in Ref. 5; AAM51132 | |||
Sequence conflict | 567 | in Ref. 5; AAM51132 | |||
Sequence conflict | 621 | in Ref. 5; AAM51132 | |||
Sequence conflict | 650 | in Ref. 5; AAM51132 | |||
Sequence conflict | 791 | in Ref. 5; AAM51132 | |||
Compositional bias | 916-932 | Polar residues | |||
Compositional bias | 933-947 | Basic and acidic residues | |||
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AE013599 EMBL· GenBank· DDBJ | AAF47220.3 EMBL· GenBank· DDBJ | Genomic DNA | ||
BT023811 EMBL· GenBank· DDBJ | AAZ66318.1 EMBL· GenBank· DDBJ | mRNA | ||
EU541213 EMBL· GenBank· DDBJ | ACB30270.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
EU541214 EMBL· GenBank· DDBJ | ACB30271.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY119272 EMBL· GenBank· DDBJ | AAM51132.1 EMBL· GenBank· DDBJ | mRNA | Different initiation |