Q9W157 · BRCA2_DROME

Function

function

Involved in and required for double-strand break repair by meiotic and mitotic homologous recombination. During meiosis, has a dual role in the repair of meiotic double-stranded breaks and the efficient activation of the meiotic recombination checkpoint.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentnucleus
Biological Processcell division
Biological ProcessDNA repair
Biological ProcessDNA synthesis involved in double-strand break repair via homologous recombination
Biological Processdouble-strand break repair via homologous recombination
Biological Processmeiotic DNA repair synthesis involved in reciprocal meiotic recombination
Biological Processmeiotic recombination checkpoint signaling
Biological Processresponse to camptothecin

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Breast cancer type 2 susceptibility protein homolog
  • Short names
    dmbrca2

Gene names

    • Name
      Brca2
    • ORF names
      CG30169

Organism names

  • Taxonomic identifier
  • Strains
    • Berkeley
    • Oregon-R
    • Zimbabwe30
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Brachycera > Muscomorpha > Ephydroidea > Drosophilidae > Drosophila > Sophophora

Accessions

  • Primary accession
    Q9W157
  • Secondary accessions
    • B2CPK7
    • B2CPK8
    • Q494G5
    • Q8MRU0

Proteomes

Organism-specific databases

Subcellular Location

Nucleus
Note: Brca2 and spn-A/Rad51 become recruited to nuclear foci after DNA damage.

Keywords

Phenotypes & Variants

Disruption phenotype

Induced sensitivity to DNA damage induced by irradiation or treatment with hydroxyurea/ Repair by homologous recombination is dramatically decreased. Instead, large flanking deletions are formed, and repair by the non-conservative single-strand annealing pathway predominates.

Features

Showing features for natural variant.

TypeIDPosition(s)Description
Natural variant242in strain: Zimbabwe30

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 1 variant from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00003929161-971Breast cancer type 2 susceptibility protein homolog

Proteomic databases

Expression

Gene expression databases

Interaction

Subunit

Interacts with Rad9 (PubMed:18266476).
Interacts with spn-A/Rad51 (PubMed:17822964).
Interacts with cyclin CycG (PubMed:22976300).

Protein-protein interaction databases

Family & Domains

Features

Showing features for region, compositional bias, repeat.

Type
IDPosition(s)Description
Region1-30Disordered
Region130-155Disordered
Compositional bias349-366Basic and acidic residues
Region349-395Disordered
Compositional bias367-395Polar residues
Compositional bias420-441Polar residues
Region420-466Disordered
Repeat570-604BRCA2 1
Repeat671-705BRCA2 2
Repeat746-780BRCA2 3
Compositional bias916-932Polar residues
Region916-971Disordered
Compositional bias933-947Basic and acidic residues

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    971
  • Mass (Da)
    108,649
  • Last updated
    2007-11-13 v3
  • Checksum
    9232DE2A667672CE
MDQNGASGSHPNRLSQGRGAHARERGATVSAAANRSNIIDEMAKICEADRQTFAIARRTRGHERLAVDNSDFVAVEDLILSYAEPTPEDQVEMIMSDFCSSPTYAEDEDEPSHESEPWFRFRNKRIRTYSRKRDPKSHKAVQNEKRRGSSGLSVQRDLNTSFTSMACDFDASSQKIHEVLLNLSQYFSATATASGPTPVPSQIDLPTEARQDSGDECFNAELENLRDDLLQSGFTFEASFYENEHEQEGPGTMADTIYGDSMQSVPTTRLRLESGKRNVWSDADSTLKKADVEIAENKKLLMGQTQAKNVDIEENTNFILEGIPLSEWLTPMELPEISKDVIKHIPDKKLKLEPSSQKEQKSSKDSNASKVRGASKQSCDINTKNEGTTILDQPNAAEQENLLNDGELLEEFLFNDWQPMQCSNGPSTSKNAIQGPKENINSINLDDKEQPEKQTPNKSQTISSHQLNGIRKKSFKFIEVSEEMKIKGEEFVDKVVSGLYHFSHKCNLRTEEYSDNHSQVMESTQCAEFKSAPSKPIEILDGKETYNAIAKVDVGEINGKFSPLNNDTIAEPEFCGFRTASNKAIPISEKMKIKTAEFMAEFQSKETIQQNDYLVHQPNDKPTSVGLDTALKRSIESSEEMRSKASKLVVVDTTMREPHQPTLDPVCRDLNESQFFGFRTASNKAIEITEAMEKRGAMFLAQSKATDQLNGWQPSDFPDVLPTSPNNEIHSINVENNKAVNTKTVSETEFFGFRTASNKGIVISENTKIKVAQFMSEFQAADASTDSNQPTVISEESRNIDAKFVDEAAAEDSANKPTFCNVQSLKNTSDIEHFKHDFFVEHSAKEEHPLCSQPLVRTPRRSQEIHSSLSQLAGKSPLDQATKKSVIARRNLLSLKRKRKIILSTETSTSCALPTMERFAPKPSSTSTPLADRDLNRSKDCTKNRQDAEDMSPICMQPKKSRRLGLSRSRY

Sequence caution

The sequence AAM51132.1 differs from that shown. Reason: Erroneous initiation

Features

Showing features for compositional bias, sequence conflict.

Type
IDPosition(s)Description
Compositional bias349-366Basic and acidic residues
Compositional bias367-395Polar residues
Compositional bias420-441Polar residues
Sequence conflict502in Ref. 5; AAM51132
Sequence conflict567in Ref. 5; AAM51132
Sequence conflict621in Ref. 5; AAM51132
Sequence conflict650in Ref. 5; AAM51132
Sequence conflict791in Ref. 5; AAM51132
Compositional bias916-932Polar residues
Compositional bias933-947Basic and acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AE013599
EMBL· GenBank· DDBJ
AAF47220.3
EMBL· GenBank· DDBJ
Genomic DNA
BT023811
EMBL· GenBank· DDBJ
AAZ66318.1
EMBL· GenBank· DDBJ
mRNA
EU541213
EMBL· GenBank· DDBJ
ACB30270.1
EMBL· GenBank· DDBJ
Genomic DNA
EU541214
EMBL· GenBank· DDBJ
ACB30271.1
EMBL· GenBank· DDBJ
Genomic DNA
AY119272
EMBL· GenBank· DDBJ
AAM51132.1
EMBL· GenBank· DDBJ
mRNA Different initiation

Genome annotation databases

Similar Proteins

Disclaimer

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