in the adult intestine Ebd acts independently of Ewg in physiological Wnt signaling but cooperates with Ewg to induce the hyperactivation of Wnt target gene expression following Apc1 loss. These findings have relevance for human tumorigenesis as Jerky (JRK/JH8) the human Ebd homolog promotes Wnt pathway hyperactivation and is overexpressed in colorectal breast and ovarian cancers
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.