Q9W0K2 · Q9W0K2_DROME
- Proteintryptophan 5-monooxygenase
- GeneTrhn
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids555 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score5/5
Function
Catalytic activity
- (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tryptophan + O2 = (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + 5-hydroxy-L-tryptophan
Cofactor
Pathway
Aromatic compound metabolism; serotonin biosynthesis; serotonin from L-tryptophan: step 1/2.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 304 | L-tryptophan (UniProtKB | ChEBI) | ||||
Sequence: Y | ||||||
Binding site | 326 | L-tryptophan (UniProtKB | ChEBI) | ||||
Sequence: R | ||||||
Binding site | 334 | L-tryptophan (UniProtKB | ChEBI) | ||||
Sequence: T | ||||||
Binding site | 341 | Fe cation (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Binding site | 346 | Fe cation (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Binding site | 386 | Fe cation (UniProtKB | ChEBI) | ||||
Sequence: E | ||||||
Binding site | 406 | L-tryptophan (UniProtKB | ChEBI) | ||||
Sequence: S | ||||||
Binding site | 436 | L-tryptophan (UniProtKB | ChEBI) | ||||
Sequence: I |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | neuron projection | |
Molecular Function | iron ion binding | |
Molecular Function | phenylalanine 4-monooxygenase activity | |
Molecular Function | tryptophan 5-monooxygenase activity | |
Biological Process | adult feeding behavior | |
Biological Process | adult locomotory behavior | |
Biological Process | larval feeding behavior | |
Biological Process | positive regulation of heart rate | |
Biological Process | regulation of circadian sleep/wake cycle, sleep | |
Biological Process | sensory perception of smell | |
Biological Process | serotonin biosynthetic process | |
Biological Process | serotonin biosynthetic process from tryptophan | |
Biological Process | sleep | |
Biological Process | tracheal pit formation in open tracheal system |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nametryptophan 5-monooxygenase
- EC number
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Brachycera > Muscomorpha > Ephydroidea > Drosophilidae > Drosophila > Sophophora
Accessions
- Primary accessionQ9W0K2
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
PTM/Processing
Proteomic databases
Expression
Gene expression databases
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for region, compositional bias, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 25-73 | Disordered | ||||
Sequence: QGSPLHQLKKDSTTSGSSSHPSLGRNASAPPEPPRLAIGGGGQDNGRQH | ||||||
Compositional bias | 30-49 | Polar residues | ||||
Sequence: HQLKKDSTTSGSSSHPSLGR | ||||||
Domain | 80-160 | ACT | ||||
Sequence: SIIFTLRNQVGNLARALQVFQELGINVLHLELSPLEMATNQADVLVDVECDQRRLDQVVKMLNREVASVNYTSVNTQGLAR | ||||||
Domain | 162-509 | Biopterin-dependent aromatic amino acid hydroxylase family profile | ||||
Sequence: PSLSACSSFDFGDMVWFPRKISDLDKAQNVLMYGSELDADHPGFKDPVYRKRREQFSAIANNFKHGNPIPRVQYTPEEVKTWGTVFLELHRLYVLHAVPEYMDNWPELEKYCGYREDNVPQLQDVSVYLKRKTGFQLRPVAGYLSPRDFLSGLAFRVFHCTQYIRHSSDPFYTPEPDCCHELLGHMPLLANSSFAQFSQEIGLASLGASDADIEKLATLYFFTVEFGLCKQADSTFKVYGAGLLSSVAELQHAITAENKIKKFDPEVTCQQECIITSYQNAYYYTDSFEEAKEQMRAFAESIQRPFGVRYNPYTMSVEVLSNAKKITAVVSELRGDLSIVCSALRKIS | ||||||
Region | 534-555 | Disordered | ||||
Sequence: ASGGGGSPCSPDNSDNSTAEGD | ||||||
Compositional bias | 540-555 | Polar residues | ||||
Sequence: SPCSPDNSDNSTAEGD |
Sequence similarities
Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length555
- Mass (Da)61,530
- Last updated2000-05-01 v1
- Checksum60D527EFB1FA791C
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 30-49 | Polar residues | ||||
Sequence: HQLKKDSTTSGSSSHPSLGR | ||||||
Compositional bias | 540-555 | Polar residues | ||||
Sequence: SPCSPDNSDNSTAEGD |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AE014296 EMBL· GenBank· DDBJ | AAF47444.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BT001418 EMBL· GenBank· DDBJ | AAN71173.1 EMBL· GenBank· DDBJ | mRNA |