Q9VZ21 · RTRV_DROME
- ProteinUPAR/Ly6 domain-containing protein rtv
- Genertv
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids151 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score5/5
Function
function
Required for chitin fiber assembly and organization involved in cuticle formation and tracheal development.
Miscellaneous
The name 'retroactive' likely refers to the propensity of hyperactive larvae to change orientation within the egg case.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | plasma membrane | |
Cellular Component | side of membrane | |
Biological Process | chitin-based embryonic cuticle biosynthetic process | |
Biological Process | open tracheal system development | |
Biological Process | positive regulation of voltage-gated potassium channel activity | |
Biological Process | regulation of synaptic transmission, cholinergic | |
Biological Process | regulation of tube architecture, open tracheal system | |
Biological Process | regulation of tube diameter, open tracheal system | |
Biological Process | sleep |
Names & Taxonomy
Protein names
- Recommended nameUPAR/Ly6 domain-containing protein rtv
- Alternative names
Gene names
Organism names
- Strains
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Brachycera > Muscomorpha > Ephydroidea > Drosophilidae > Drosophila > Sophophora
Accessions
- Primary accessionQ9VZ21
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Lipid-anchor, GPI-anchor
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Topological domain | 20-125 | Extracellular | |||
Transmembrane | 126-146 | Helical | |||
Topological domain | 147-151 | Cytoplasmic | |||
Keywords
- Cellular component
Phenotypes & Variants
Disruption phenotype
Larval lethal as larvae are unable to hatch (PubMed:15844167).
Larvae are hyperactive and occasionally change orientation in the egg case (PubMed:15844167).
Tissues that produce a chitin cuticle, such as the skull and the trachea, fail to form properly (PubMed:15844167, PubMed:16339194).
Disorganization of chitin fibers in the cuticle and in the trachea (PubMed:15844167, PubMed:16339194, PubMed:19502482).
Elongated and convoluted tracheal dorsal trunk with tracheal lumen expansion defects in stage 14 to 16 embryos, possibly due to uncoordinated apical cell surface expansion (PubMed:16339194, PubMed:19502482).
Detachment of the cuticle from the underlying epidermis allowing it to expand giving a bloated phenotype (PubMed:15844167).
Larvae are hyperactive and occasionally change orientation in the egg case (PubMed:15844167).
Tissues that produce a chitin cuticle, such as the skull and the trachea, fail to form properly (PubMed:15844167, PubMed:16339194).
Disorganization of chitin fibers in the cuticle and in the trachea (PubMed:15844167, PubMed:16339194, PubMed:19502482).
Elongated and convoluted tracheal dorsal trunk with tracheal lumen expansion defects in stage 14 to 16 embryos, possibly due to uncoordinated apical cell surface expansion (PubMed:16339194, PubMed:19502482).
Detachment of the cuticle from the underlying epidermis allowing it to expand giving a bloated phenotype (PubMed:15844167).
PTM/Processing
Features
Showing features for signal, chain, disulfide bond, glycosylation, lipidation, propeptide.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Signal | 1-19 | ||||
Chain | PRO_5015020178 | 20-121 | UPAR/Ly6 domain-containing protein rtv | ||
Disulfide bond | 26↔65 | ||||
Disulfide bond | 29↔38 | ||||
Glycosylation | 45 | N-linked (GlcNAc...) asparagine | |||
Disulfide bond | 60↔88 | ||||
Disulfide bond | 100↔113 | ||||
Disulfide bond | 115↔120 | ||||
Lipidation | 121 | GPI-anchor amidated asparagine | |||
Propeptide | PRO_0000459700 | 122-151 | Removed in mature form | ||
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Developmental stage
Expression coincides with formation of the procuticle in the developing head skeleton, pharynx and trachea at stage 16 and 17 of embryogenesis, and in epidermal cells at stage 17.
Gene expression databases
Structure
Family & Domains
Sequence similarities
Belongs to the quiver family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence & Isoform
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
This entry describes 2 isoforms produced by Alternative splicing.
Q9VZ21-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- NameA
- SynonymsB, D
- Length151
- Mass (Da)16,843
- Last updated2000-05-01 v1
- Checksum06D78037E46FC8B1
Q9VZ21-2
- NameC
- Differences from canonical
- 1-86: Missing
Features
Showing features for alternative sequence.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Alternative sequence | VSP_062239 | 1-86 | in isoform C | ||
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AM999233 EMBL· GenBank· DDBJ | CAQ53595.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AM999234 EMBL· GenBank· DDBJ | CAQ53596.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AM999235 EMBL· GenBank· DDBJ | CAQ53597.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FM246338 EMBL· GenBank· DDBJ | CAR94264.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FM246339 EMBL· GenBank· DDBJ | CAR94265.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FM246340 EMBL· GenBank· DDBJ | CAR94266.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FM246341 EMBL· GenBank· DDBJ | CAR94267.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FM246343 EMBL· GenBank· DDBJ | CAR94269.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FM246344 EMBL· GenBank· DDBJ | CAR94270.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FM246345 EMBL· GenBank· DDBJ | CAR94271.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AE014298 EMBL· GenBank· DDBJ | AAF48010.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AE014298 EMBL· GenBank· DDBJ | AGB95285.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AE014298 EMBL· GenBank· DDBJ | AGB95286.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AE014298 EMBL· GenBank· DDBJ | AHN59584.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY061126 EMBL· GenBank· DDBJ | AAL28674.1 EMBL· GenBank· DDBJ | mRNA | ||
KX531353 EMBL· GenBank· DDBJ | ANY27163.1 EMBL· GenBank· DDBJ | mRNA |