The genome sequence of Drosophila melanogaster.Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A.[...], Venter J.C.View abstractCited forNUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]StrainBerkeleyCategoriesSequencesSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCScience 287:2185-2195 (2000)Cited in99+99+Mapped to9
Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H.[...], Lewis S.E.View abstractCited forGENOME REANNOTATIONStrainBerkeleyCategoriesSequencesSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCGenome Biol. 3:RESEARCH0083.1-RESEARCH0083.22 (2002)Cited in99+99+Mapped to25
A Drosophila full-length cDNA resource.Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A., Guarin H., Kronmiller B., Pacleb J.M.[...], Celniker S.E.View abstractCited forNUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]StrainBerkeleyTissueEmbryoCategoriesSequencesSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCGenome Biol. 3:RESEARCH0080.1-RESEARCH0080.8 (2002)Cited in99+Mapped to93
A Tumor suppressor complex with GAP activity for the Rag GTPases that signal amino acid sufficiency to mTORC1.Bar-Peled L., Chantranupong L., Cherniack A.D., Chen W.W., Ottina K.A., Grabiner B.C., Spear E.D., Carter S.L., Meyerson M., Sabatini D.M.View abstractCited forFUNCTIONCategoriesFunctionSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCScience 340:1100-1106 (2013)Cited in17Mapped to45
The TORC1 inhibitors Nprl2 and Nprl3 mediate an adaptive response to amino-acid starvation in Drosophila.Wei Y., Lilly M.A.View abstractCited forFUNCTION, INTERACTION WITH NPRL3, SUBCELLULAR LOCATION, DISRUPTION PHENOTYPECategoriesFunction, Interaction, Phenotypes & Variants, Subcellular LocationSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCCell Death Differ. 21:1460-1468 (2014)Cited in3Mapped to5
TORC1 regulators Iml1/GATOR1 and GATOR2 control meiotic entry and oocyte development in Drosophila.Wei Y., Reveal B., Reich J., Laursen W.J., Senger S., Akbar T., Iida-Jones T., Cai W., Jarnik M., Lilly M.A.View abstractCited forFUNCTION, DISRUPTION PHENOTYPECategoriesFunction, Phenotypes & VariantsSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCProc. Natl. Acad. Sci. U.S.A. 111:E5670-E5677 (2014)Cited in5Mapped to13
The GATOR1 Complex Regulates Metabolic Homeostasis and the Response to Nutrient Stress in Drosophila melanogaster.Wei Y., Reveal B., Cai W., Lilly M.A.View abstractCited forFUNCTION, DISRUPTION PHENOTYPECategoriesFunction, Phenotypes & VariantsSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCG3 (Bethesda) 6:3859-3867 (2016)Cited in3Mapped to12
The GATOR2 component Wdr24 regulates TORC1 activity and lysosome function.Cai W., Wei Y., Jarnik M., Reich J., Lilly M.A.View abstractCited forFUNCTION, IDENTIFICATION IN THE GATOR COMPLEXCategoriesFunction, InteractionSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCPLoS Genet. 12:E1006036-E1006036 (2016)Cited in9Mapped to26
An evolutionary mechanism to assimilate new nutrient sensors into the mTORC1 pathway.Liu G.Y., Jouandin P., Bahng R.E., Perrimon N., Sabatini D.M.View abstractSourceFlyBase: FBgn0030800PubMedEurope PMCNat Commun 15:2517-2517 (2024)Mapped to26
Differential amino acid transporter expression in adult <i>Drosophila melanogaster</i> tissues.Wright Y., Armstrong A.R.View abstractSourceFlyBase: FBgn0030800PubMedEurope PMCMicroPubl Biol 2024:0-0 (2024)Mapped to57
Functional characterization of novel NPRL3 mutations identified in three families with focal epilepsy.Du S., Zeng S., Song L., Ma H., Chen R., Luo J., Wang X., Ma T., Xu X.[...], Tang B.View abstractSourceFlyBase: FBgn0030800PubMedEurope PMCSci China Life Sci 66:2152-2166 (2023)Mapped to7
Wdr59 promotes or inhibits TORC1 activity depending on cellular context.Zhang Y., Ting C.Y., Yang S., Reich J., Fru K., Lilly M.A.View abstractCategoriesFunction, InteractionSourceFlyBase: FBgn0030800PubMedEurope PMCProc. Natl. Acad. Sci. U.S.A. 120:e2212330120-e2212330120 (2023)Cited in2Mapped to17
Stress-induced reversible cell-cycle arrest requires PRC2/PRC1-mediated control of mitophagy in Drosophila germline stem cells and human iPSCs.Taslim T.H., Hussein A.M., Keshri R., Ishibashi J.R., Chan T.C., Nguyen B.N., Liu S., Brewer D., Harper S.[...], Ruohola-Baker H.View abstractCategoriesFunctionSourceFlyBase: FBgn0030800PubMedEurope PMCStem Cell Reports 18:269-288 (2023)Mapped to99+
Mitochondrial DNA quality control in the female germline requires a unique programmed mitophagy.Palozzi J.M., Jeedigunta S.P., Minenkova A.V., Monteiro V.L., Thompson Z.S., Lieber T., Hurd T.R.View abstractSourceFlyBase: FBgn0030800PubMedEurope PMCCell Metab 34:1809-1823.e6 (2022)Mapped to99+
Sestrin mediates detection of and adaptation to low-leucine diets in Drosophila.Gu X., Jouandin P., Lalgudi P.V., Binari R., Valenstein M.L., Reid M.A., Allen A.E., Kamitaki N., Locasale J.W.[...], Sabatini D.M.View abstractCategoriesFunctionSourceFlyBase: FBgn0030800PubMedEurope PMCNature 608:209-216 (2022)Mapped to17
Macrophage mitochondrial bioenergetics and tissue invasion are boosted by an Atossa-Porthos axis in Drosophila.Emtenani S., Martin E.T., Gyoergy A., Bicher J., Genger J.W., Koecher T., Akhmanova M., Guarda M., Roblek M.[...], Siekhaus D.E.View abstractCategoriesFunctionSourceFlyBase: FBgn0030800PubMedEurope PMCEMBO J. 41:e109049-e109049 (2022)Cited in4Mapped to31
Lysosomal cystine mobilization shapes the response of TORC1 and tissue growth to fasting.Jouandin P., Marelja Z., Shih Y.H., Parkhitko A.A., Dambowsky M., Asara J.M., Nemazanyy I., Dibble C.C., Simons M., Perrimon N.View abstractCategoriesFunctionSourceFlyBase: FBgn0030800PubMedEurope PMCScience 375:eabc4203-eabc4203 (2022)Mapped to31
Genome-wide phenotypic RNAi screen in the Drosophila wing: phenotypic description of functional classes.Lopez-Varea A., Vega-Cuesta P., Ruiz-Gomez A., Ostale C.M., Molnar C., Hevia C.F., Martin M., Organista M.F., de Celis J.[...], de Celis J.F.View abstractCategoriesFunctionSourceFlyBase: FBgn0030800PubMedEurope PMCG3 (Bethesda) 11:jkab349-jkab349 (2021)Mapped to99+
FKBP39 controls nutrient dependent Nprl3 expression and TORC1 activity in Drosophila.Zhou Y., Guo J., Wang X., Cheng Y., Guan J., Barman P., Sun M.A., Fu Y., Wei W.[...], Wei Y.View abstractCategoriesFunctionSourceFlyBase: FBgn0030800PubMedEurope PMCCell Death Dis 12:571-571 (2021)Mapped to27
Methionine restriction breaks obligatory coupling of cell proliferation and death by an oncogene Src in <i>Drosophila</i>.Nishida H., Okada M., Yang L., Takano T., Tabata S., Soga T., Ho D.M., Chung J., Minami Y., Yoo S.K.View abstractCategoriesFunctionSourceFlyBase: FBgn0030800PubMedEurope PMCElife 10:e59809-e59809 (2021)Mapped to74
Drosophila as a model system for deciphering the 'host physiology- nutrition-microbiome' axis.Lee J.H., Lee K.A., Lee W.J.View abstractCategoriesFunctionSourceFlyBase: FBgn0030800PubMedEurope PMCCurr Opin Insect Sci 41:112-119 (2020)Mapped to69
An intestinal zinc sensor regulates food intake and developmental growth.Redhai S., Pilgrim C., Gaspar P., Giesen L.V., Lopes T., Riabinina O., Grenier T., Milona A., Chanana B.[...], Miguel-Aliaga I.View abstractCategoriesFunctionSourceFlyBase: FBgn0030800PubMedEurope PMCNature 580:263-268 (2020)Cited in5Mapped to32
CRISPR-based modular assembly of a UAS-cDNA/ORF plasmid library for more than 5500 <i>Drosophila</i> genes conserved in humans.Wei P., Xue W., Zhao Y., Ning G., Wang J.View abstractCategoriesFunctionSourceFlyBase: FBgn0030800PubMedEurope PMCGenome Res 30:95-106 (2020)Mapped to99+
The TORC1 inhibitor Nprl2 protects age-related digestive function in <i>Drosophila</i>.Xi J., Cai J., Cheng Y., Fu Y., Wei W., Zhang Z., Zhuang Z., Hao Y., Lilly M.A., Wei Y.View abstractAnnotationThe TORC1 inhibitor Nprl2 protects age-related digestive function in Drosophila.CategoriesFunction, Phenotypes & VariantsSourceFlyBase: FBgn0030800, GeneRif: 32677PubMedEurope PMCAging (Albany NY) 11:9811-9828 (2019)Mapped to7
The GATOR complex regulates an essential response to meiotic double- stranded breaks in <i>Drosophila</i>.Wei Y., Bettedi L., Ting C.Y., Kim K., Zhang Y., Cai J., Lilly M.A.View abstractCategoriesFunction, Phenotypes & VariantsSourceFlyBase: FBgn0030800PubMedEurope PMCElife 8:e42149-e42149 (2019)Mapped to35