ASH1, a Drosophila trithorax group protein, is required for methylation of lysine 4 residues on histone H3.Byrd K.N., Shearn A.View abstractCited forFUNCTION, SET DOMAIN, CATALYTIC ACTIVITYCategoriesFunction, Family & DomainsSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCProc. Natl. Acad. Sci. U.S.A. 100:11535-11540 (2003)Cited in1Mapped to1
The histone methyltransferases Trithorax and Ash1 prevent transcriptional silencing by Polycomb group proteins.Klymenko T., Mueller J.View abstractCited forFUNCTIONCategoriesFunctionSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCEMBO Rep. 5:373-377 (2004)Cited in1Mapped to16
Histone trimethylation and the maintenance of transcriptional ON and OFF states by trxG and PcG proteins.Papp B., Mueller J.View abstractCited forFUNCTION, SUBCELLULAR LOCATIONCategoriesFunction, Subcellular LocationSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCGenes Dev. 20:2041-2054 (2006)Cited in1Mapped to42
LUSH odorant-binding protein mediates chemosensory responses to alcohols in Drosophila melanogaster.Kim M.-S., Repp A., Smith D.P.View abstractCategoriesFunction, Phenotypes & VariantsSourceFlyBase: FBgn0005386PubMedEurope PMCGenetics 150:711-721 (1998)Cited in1Mapped to7
AT-hook motifs identified in a wide variety of DNA-binding proteins.Aravind L., Landsman D.View abstractCategoriesFunction, InteractionSourceFlyBase: FBgn0005386PubMedEurope PMCNucleic Acids Res 26:4413-4421 (1998)Mapped to34
Asymmetric cell division.Jan Y.N., Jan L.Y.View abstractCategoriesFunctionSourceFlyBase: FBgn0005386PubMedEurope PMCNature 392:775-778 (1998)Mapped to24
SET domain proteins modulate chromatin domains in eu- and heterochromatin.Jenuwein T., Laible G., Dorn R., Reuter G.View abstractCategoriesFunction, Phenotypes & VariantsSourceFlyBase: FBgn0005386PubMedEurope PMCCell Mol Life Sci 54:80-93 (1998)Mapped to63
Functional analysis of mouse Polycomb group genes.van Lohuizen M.View abstractCategoriesFunction, Phenotypes & VariantsSourceFlyBase: FBgn0005386PubMedEurope PMCCell Mol Life Sci 54:71-79 (1998)Mapped to51
Chromatin-silencing mechanisms in Drosophila maintain patterns of gene expression.Pirrotta V.View abstractCategoriesFunctionSourceFlyBase: FBgn0005386PubMedEurope PMCTrends Genet 13:314-318 (1997)Mapped to34
E(z): a polycomb group gene or a trithorax group gene?LaJeunesse D., Shearn A.View abstractCategoriesFunctionSourceFlyBase: FBgn0005386PubMedEurope PMCDevelopment 122:2189-2197 (1996)Mapped to11
Regulation of polyhomeotic transcription may involve local changes in chromatin activity in Drosophila.Fauvarque M.O., Zuber V., Dura J.M.View abstractCategoriesFunctionSourceFlyBase: FBgn0005386PubMedEurope PMCMech Dev 52:343-355 (1995)Mapped to99+
Imaginal disc abnormalities in lethal mutants of Drosophila.Shearn A., Rice T., Garen A., Gehring W.View abstractCategoriesFunction, Phenotypes & VariantsSourceFlyBase: FBgn0005386PubMedEurope PMCProc Natl Acad Sci U S A 68:2594-2598 (1971)Mapped to16
Methylation of lysine 36 on histone H3 is required to control transposon activities in somatic cells.Lindehell H., Schwartz Y.B., Larsson J.View abstractCategoriesFunctionSourceFlyBase: FBgn0005386PubMedEurope PMCLife Sci Alliance 6:e202201832-e202201832 (2023)Mapped to5
Transgenerational inheritance of wing development defects in Drosophila melanogaster induced by cadmium.Sun L., Mu Y., Xu L., Han X., Gu W., Zhang M.View abstractCategoriesFunction, Phenotypes & VariantsSourceFlyBase: FBgn0005386PubMedEurope PMCEcotoxicol Environ Saf 250:114486-114486 (2023)Mapped to18
Systematic identification and characterization of repressive domains in Drosophila transcription factors.Klaus L., de Almeida B.P., Vlasova A., Nemcko F., Schleiffer A., Bergauer K., Hofbauer L., Rath M., Stark A.View abstractCategoriesFunction, Phenotypes & VariantsSourceFlyBase: FBgn0005386PubMedEurope PMCEMBO J 42:e112100-e112100 (2023)Mapped to99+
An expanded toolkit for <i>Drosophila</i> gene tagging using synthesized homology donor constructs for CRISPR-mediated homologous recombination.Kanca O., Zirin J., Hu Y., Tepe B., Dutta D., Lin W.W., Ma L., Ge M., Zuo Z.[...], Bellen H.J.View abstractCategoriesFunctionSourceFlyBase: FBgn0005386PubMedEurope PMCElife 11:e76077-e76077 (2022)Mapped to99+
A prominent gene activation role for C-terminal binding protein in mediating PcG/trxG proteins through Hox gene regulation.Bi C.L., Cheng Q., Yan L.Y., Wu H.Y., Wang Q., Wang P., Cheng L., Wang R., Yang L.[...], Fang M.View abstractCategoriesFunction, InteractionSourceFlyBase: FBgn0005386PubMedEurope PMCDevelopment 149:dev200153-dev200153 (2022)Mapped to51
Histone H3.3 K27M and K36M mutations de-repress transposable elements through perturbation of antagonistic chromatin marks.Chaouch A., Berlandi J., Chen C.C.L., Frey F., Badini S., Harutyunyan A.S., Chen X., Krug B., Hebert S.[...], Jabado N.View abstractCategoriesFunctionSourceFlyBase: FBgn0005386PubMedEurope PMCMol Cell 81:4876-4890.e7 (2021)Mapped to41
A behavioral screen for mediators of age-dependent TDP-43 neurodegeneration identifies SF2/SRSF1 among a group of potent suppressors in both neurons and glia.Azpurua J., El-Karim E.G., Tranquille M., Dubnau J.View abstractCategoriesFunctionSourceFlyBase: FBgn0005386PubMedEurope PMCPLoS Genet 17:e1009882-e1009882 (2021)Mapped to89
Genome-wide phenotypic RNAi screen in the Drosophila wing: phenotypic description of functional classes.Lopez-Varea A., Vega-Cuesta P., Ruiz-Gomez A., Ostale C.M., Molnar C., Hevia C.F., Martin M., Organista M.F., de Celis J.[...], de Celis J.F.View abstractCategoriesFunctionSourceFlyBase: FBgn0005386PubMedEurope PMCG3 (Bethesda) 11:jkab349-jkab349 (2021)Mapped to99+
The role of H3K36 methylation and associated methyltransferases in chromosome-specific gene regulation.Lindehell H., Glotov A., Dorafshan E., Schwartz Y.B., Larsson J.View abstractCategoriesFunctionSourceFlyBase: FBgn0005386PubMedEurope PMCSci Adv 7:eabh4390-eabh4390 (2021)Mapped to11
The Trithorax group protein ASH1 requires a combination of BAH domain and AT hooks, but not the SET domain, for mitotic chromatin binding and survival.Steffen P.A., Altmutter C., Dworschak E., Junttila S., Gyenesei A., Zhu X., Kockmann T., Ringrose L.View abstractAnnotationThe Trithorax group protein ASH1 requires a combination of BAH domain and AT hooks but not the SET domain for mitotic chromatin binding and survival.CategoriesFunction, Phenotypes & VariantsSourceFlyBase: FBgn0005386, GeneRif: 40133PubMedEurope PMCChromosoma 130:215-234 (2021)Mapped to7
Kinome-Wide RNAi Screen Uncovers Role of Ballchen in Maintenance of Gene Activation by Trithorax Group in <i>Drosophila</i>.Khan M.H.F., Akhtar J., Umer Z., Shaheen N., Shaukat A., Munir M.S., Mithani A., Anwar S., Tariq M.View abstractCategoriesFunctionSourceFlyBase: FBgn0005386PubMedEurope PMCFront Cell Dev Biol 9:637873-637873 (2021)Mapped to99+
Homeostatic plasticity fails at the intersection of autism-gene mutations and a novel class of common genetic modifiers.Genc O., An J.Y., Fetter R.D., Kulik Y., Zunino G., Sanders S.J., Davis G.W.View abstractCategoriesFunction, Phenotypes & VariantsSourceFlyBase: FBgn0005386PubMedEurope PMCElife 9:e55775-e55775 (2020)Mapped to46
De Novo Variants in CNOT1, a Central Component of the CCR4-NOT Complex Involved in Gene Expression and RNA and Protein Stability, Cause Neurodevelopmental Delay.DDD StudyVissers L.E.L.M., Kalvakuri S., de Boer E., Geuer S., Oud M., van Outersterp I., Kwint M., Witmond M., Kersten S.[...], de Brouwer A.P.M.View abstractCategoriesFunctionSourceFlyBase: FBgn0005386PubMedEurope PMCAm. J. Hum. Genet. 107:164-172 (2020)Cited in1Mapped to30