Q9VU37 · Q9VU37_DROME

Function

function

Catalyzes the post-translational methylation of isoprenylated C-terminal cysteine residues.

Catalytic activity

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentendoplasmic reticulum
Cellular Componentendoplasmic reticulum membrane
Molecular Functionprotein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
Biological ProcessC-terminal protein methylation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Protein-S-isoprenylcysteine O-methyltransferase
  • EC number

Gene names

    • Name
      Icmt
    • Synonyms
      Dmel\CG11268
      , Dmel\Ste14
      , ICMT
      , Ste14
      , ste14
    • ORF names
      CG11268
      , Dmel_CG11268

Organism names

  • Taxonomic identifier
  • Strain
    • Berkeley
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Brachycera > Muscomorpha > Ephydroidea > Drosophilidae > Drosophila > Sophophora

Accessions

  • Primary accession
    Q9VU37

Proteomes

Organism-specific databases

Subcellular Location

Endoplasmic reticulum membrane
; Multi-pass membrane protein
Membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane23-40Helical
Transmembrane52-74Helical
Transmembrane81-104Helical
Transmembrane110-130Helical
Transmembrane172-189Helical
Transmembrane232-260Helical

Keywords

PTM/Processing

Proteomic databases

Expression

Gene expression databases

    • FBgn0036336Expressed in adult class III enteroendocrine cell in adult midgut (Drosophila) and 51 other cell types or tissues

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    299
  • Mass (Da)
    34,104
  • Last updated
    2000-05-01 v1
  • Checksum
    619350D9416E71AF
MCAKSRVASPGAGGTSLCSEGRISLYCFLITAALVLIPSVPQNLYGVVPQVWGAVLWGPFLYYALINMIIRFVLRNHDYQVAIRASFLGFAMAVSVLVICFAPTEWQQFGAYGCFMSLFHYSEFLVIAFANPRTLSLDSFMLNHSVHYGLAAAASWIEFSLEVYYLPQFKRYGYIWVAGVVLCLLGEMVRKAAIITAGRSFTHLVQNEKHSEHKLITSGIYAYCRHPSYVGWFWWSIGTQIVLLNPICICIYTLVSWLFFHDRIYVEEYSLLNFFQSDYVRYQKRVPTGLPFIRGYLVD

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AE014296
EMBL· GenBank· DDBJ
AAF49854.1
EMBL· GenBank· DDBJ
Genomic DNA
AY070700
EMBL· GenBank· DDBJ
AAL48171.1
EMBL· GenBank· DDBJ
mRNA
AY071003
EMBL· GenBank· DDBJ
AAL48625.1
EMBL· GenBank· DDBJ
mRNA
AE014296
EMBL· GenBank· DDBJ
AGB94486.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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