Q9VTZ4 · Q9VTZ4_DROME

Function

function

Catalyzes the conversion of GlcNAc-6-P into GlcNAc-1-P during the synthesis of uridine diphosphate/UDP-GlcNAc, a sugar nucleotide critical to multiple glycosylation pathways including protein N- and O-glycosylation.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 1 Mg2+ ion per subunit.

Pathway

Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; N-acetyl-alpha-D-glucosamine 1-phosphate from alpha-D-glucosamine 6-phosphate (route I): step 2/2.

Features

Showing features for active site, binding site.

TypeIDPosition(s)Description
Active site68Phosphoserine intermediate
Binding site68Mg2+ (UniProtKB | ChEBI); via phosphate group
Binding site283Mg2+ (UniProtKB | ChEBI)
Binding site285Mg2+ (UniProtKB | ChEBI)
Binding site287Mg2+ (UniProtKB | ChEBI)
Binding site377-379substrate
Binding site498-502substrate
Binding site507substrate

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functionmagnesium ion binding
Molecular Functionphosphoacetylglucosamine mutase activity
Biological Processcarbohydrate metabolic process
Biological Processmesodermal cell fate commitment
Biological Processpositive regulation of fibroblast growth factor receptor signaling pathway
Biological Processtrachea development
Biological ProcessUDP-N-acetylglucosamine biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Phosphoacetylglucosamine mutase
  • EC number
  • Short names
    PAGM
  • Alternative names
    • Acetylglucosamine phosphomutase
    • N-acetylglucosamine-phosphate mutase

Gene names

    • Name
      nst
    • Synonyms
      Dmel\CG10627
      , DPgm3
      , PGM3
      , Pgm3
    • ORF names
      CG10627
      , Dmel_CG10627

Organism names

  • Taxonomic identifier
  • Strain
    • Berkeley
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Brachycera > Muscomorpha > Ephydroidea > Drosophilidae > Drosophila > Sophophora

Accessions

  • Primary accession
    Q9VTZ4

Proteomes

Organism-specific databases

Subcellular Location

PTM/Processing

Proteomic databases

Expression

Gene expression databases

    • FBgn0036298Expressed in embryonic/larval hemocyte (Drosophila) and 56 other cell types or tissues

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain60-93Alpha-D-phosphohexomutase alpha/beta/alpha
Domain108-175Alpha-D-phosphohexomutase alpha/beta/alpha
Domain183-290Phosphoacetylglucosamine mutase AMG1
Domain304-437Phosphoacetylglucosamine mutase AMG1
Domain475-524Alpha-D-phosphohexomutase C-terminal

Sequence similarities

Belongs to the phosphohexose mutase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    549
  • Mass (Da)
    60,581
  • Last updated
    2000-05-01 v1
  • Checksum
    62D2F691AC423465
MSINLRTVYAFAREMYPKTSKETIQYGTAGFRGKAEFLDSVMFRMGVLATLRSRYRGGSVIGVMITASHNPEPDNGVKLVDPKGEMLEASWEAIATDLVNVSDQELEQQVAKIIKDNNIDVTTSSQVFVGMDNRYHSPRLLKAVADGVIALKGNVKEYGIVTTPMLHYFVVAANTKEAYGKPTEEGYYDKLIKAFELLRNGRLENGNYRNSIIYDGANGVGARKMLQFIKRMKGTLNVTVINQGIGVGKINEDCGADYVKVQQSPPKSMPEDVKPYTRCVSVDGDADRVVYFFTDDKGEFHLLDGDRIATLIAGYLMELVTQSEISLRLGLVQTAYANGASTDYIVDQLKFPVSCVPTGVKHLHHKALEYDIGVYFEANGHGTIVFSDNAKATIAQVAQTKESAKTLLLLIDLINETVGDAISDMLLVETILNHKGWDVQDWISSYNDLPNRQLKVKVQDRNVIETTDAERVCVKPEGLQTEINQVVAKYKRGRSFVRPSGTEDVVRVYAEAATKEDTDNLAYEVGLLVQKLAGGVGPPLTKPNSSAHL

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AE014296
EMBL· GenBank· DDBJ
AAF49901.1
EMBL· GenBank· DDBJ
Genomic DNA
AY069309
EMBL· GenBank· DDBJ
AAL39454.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

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