Q9VTN0 · GR68A_DROME

Function

function

Dsx-dependent essential component of pheromone-driven courtship behavior (PubMed:12971900).
Recognizes a female pheromone involved in the second step (tapping step) of the courtship display which is essential for efficient execution of the entire courtship sequence and timely mating (PubMed:12971900).
Required for detection of the male sex pheromone CH503 which is transferred from males to females during mating and inhibits courtship behavior by other males (PubMed:26083710).
Gr68a-expressing neurons in the male foreleg relay signals to the suboesophageal zone (SEZ) and courtship suppression is mediated by the release of the neuropeptide tachykinin from a cluster of 8-10 neurons in the SEZ (PubMed:26083710).

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentaxon
Cellular Componentdendrite
Cellular Componentmembrane
Cellular Componentneuronal cell body
Cellular Componentplasma membrane
Molecular Functionligand-gated monoatomic ion channel activity
Molecular Functiontaste receptor activity
Biological Processchemosensory behavior
Biological Processdetection of chemical stimulus involved in sensory perception of taste
Biological Processmale courtship behavior
Biological Processmale courtship behavior, tapping to detect pheromone
Biological Processmonoatomic ion transmembrane transport
Biological Processresponse to pheromone
Biological Processsensory perception of taste
Biological Processsignal transduction

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Gustatory receptor 68a

Gene names

    • Name
      Gr68a
    • Synonyms
      GR68D.1
    • ORF names
      CG7303

Organism names

  • Taxonomic identifier
  • Strain
    • Berkeley
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Brachycera > Muscomorpha > Ephydroidea > Drosophilidae > Drosophila > Sophophora

Accessions

  • Primary accession
    Q9VTN0

Proteomes

Organism-specific databases

Subcellular Location

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain1-42Cytoplasmic
Transmembrane43-63Helical; Name=1
Topological domain64-82Extracellular
Transmembrane83-103Helical; Name=2
Topological domain104-133Cytoplasmic
Transmembrane134-154Helical; Name=3
Topological domain155-164Extracellular
Transmembrane165-185Helical; Name=4
Topological domain186-236Cytoplasmic
Transmembrane237-257Helical; Name=5
Topological domain258-281Extracellular
Transmembrane282-302Helical; Name=6
Topological domain303-352Cytoplasmic
Transmembrane353-373Helical; Name=7
Topological domain374-389Extracellular

Keywords

Phenotypes & Variants

Disruption phenotype

Mutant males display robust courtship behavior in the presence of CH503-perfumed females.

PTM/Processing

Features

Showing features for chain, glycosylation.

TypeIDPosition(s)Description
ChainPRO_00002165361-389Gustatory receptor 68a
Glycosylation80N-linked (GlcNAc...) asparagine
Glycosylation258N-linked (GlcNAc...) asparagine

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Expressed in chemosensory neurons of about 20 male-specific gustatory bristles in the forelegs (PubMed:12971900).
No expression is seen in the mechanosensory neurons (PubMed:12971900).
In larvae, expressed in the ventral pharyngeal sense organ (PubMed:22031876).

Gene expression databases

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Sequence

  • Sequence status
    Complete
  • Length
    389
  • Mass (Da)
    43,780
  • Last updated
    2002-05-02 v2
  • Checksum
    59A55E4895BDEC3B
MKIYQDIYPISKPSQIFAILPFYSGDVDDGFRFGGLGRWYGRLVALIILIGSLTLGEDVLFASKEYRLVASAQGDTEEINRTIETLLCIISYTMVVLSSVQNASRHFRTLHDIAKIDEYLLANGFRETYSCRNLTILVTSAAGGVLAVAFYYIHYRSGIGAKRQIILLLIYFLQLLYSTLLALYLRTLMMNLAQRIGFLNQKLDTFNLQDCGHMENWRELSNLIEVLCKFRYITENINCVAGVSLLFYFGFSFYTVTNQSYLAFATLTAGSLSSKTEVADTIGLSCIWVLAETITMIVICSACDGLASEVNGTAQILARIYGKSKQFQNLIDKFLTKSIKQDLQFTAYGFFSIDNSTLFKIFSAVTTYLVILIQFKQLEDSKVEDISQA

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AE014296
EMBL· GenBank· DDBJ
AAF50017.2
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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