Q9VTM6 · CRIM_DROME

Function

function

Required for septate junction assembly possibly by organizing the preassembly and transport of septate junction proteins (PubMed:20570942).
Involved in epithelial cell septate junction-mediated paracellular barrier functions of trachea, hindgut and salivary gland (PubMed:20570942).

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentseptate junction
Cellular Componentside of membrane
Biological Processliquid clearance, open tracheal system
Biological Processregulation of synaptic transmission, cholinergic
Biological Processregulation of tube size, open tracheal system
Biological Processrhythmic process
Biological Processseptate junction assembly
Biological Processsleep

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    UPAR/Ly6 domain-containing protein crim
  • Alternative names
    • Protein crimpled

Gene names

    • Name
      crim
    • ORF names
      CG6038

Organism names

  • Taxonomic identifier
  • Strain
    • Berkeley
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Brachycera > Muscomorpha > Ephydroidea > Drosophilidae > Drosophila > Sophophora

Accessions

  • Primary accession
    Q9VTM6

Proteomes

Organism-specific databases

Subcellular Location

Membrane
; Lipid-anchor, GPI-anchor

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain23-136Extracellular
Transmembrane137-157Helical
Topological domain158Cytoplasmic

Keywords

Phenotypes & Variants

Disruption phenotype

Conditional RNAi mediated knock-down in tracheal cells leads to aberrant tracheal dorsal trunk development resulting in tracheal tube size defects (PubMed:20570942).
Conditional RNAi knock-down in tracheal cells compromises epithelial paracellular barrier function in trachea due to reduced and irregular septate junction formation (PubMed:20570942).

PTM/Processing

Features

Showing features for signal, chain, glycosylation, lipidation, propeptide.

TypeIDPosition(s)Description
Signal1-22
ChainPRO_501510062523-135UPAR/Ly6 domain-containing protein crim
Glycosylation107N-linked (GlcNAc...) asparagine
Lipidation135GPI-anchor amidated asparagine
PropeptidePRO_0000459698136-158Removed in mature form

Keywords

Proteomic databases

Expression

Gene expression databases

    • FBgn0036198Expressed in seminal fluid secreting gland and 34 other tissues

Interaction

Protein-protein interaction databases

Family & Domains

Sequence similarities

Belongs to the quiver family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    158
  • Mass (Da)
    17,744
  • Last updated
    2000-05-01 v1
  • Checksum
    DD974BBCB148BCCA
MHYHTNLIAALLLAALIHEGSAIWCYRCTSATPGCAEKFNWRGIGFLGEHCPEPDDICVKVTERRGARETITRDCLSALSFRKDIPADKYEGCRPAAHDEKLANYVNHTIKEHDVRRDYYTDTTFCFCFLDHRCNGASGLQTSAVIGLLTLIPALLLR

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AE014296
EMBL· GenBank· DDBJ
AAF50021.1
EMBL· GenBank· DDBJ
Genomic DNA
AY060768
EMBL· GenBank· DDBJ
AAL28316.1
EMBL· GenBank· DDBJ
mRNA
KX531850
EMBL· GenBank· DDBJ
ANY27660.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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