Variant functional assessment in <i>Drosophila</i> by overexpression: what can we learn?Her Y., Pascual D., Goldstone-Joubert Z., Marcogliese P.View abstractCategoriesFunctionSourceFlyBase: FBgn0015618PubMedEurope PMCGenome 67:158-167 (2024)Mapped to99+
A transcriptomics-based RNAi screen for regulators of meiosis and early stages of oocyte development in Drosophila melanogaster.Hughes S.E., Price A., Briggs S., Staber C., James M., Anderson M., Hawley R.S.View abstractCategoriesFunctionSourceFlyBase: FBgn0015618PubMedEurope PMCG3 (Bethesda) 14:jkae028-jkae028 (2024)Mapped to59
Bone morphogenetic protein signaling: the pathway and its regulation.Akiyama T., Raftery L.A., Wharton K.A.View abstractCategoriesFunctionSourceFlyBase: FBgn0015618PubMedEurope PMCGenetics 226:iyad200-iyad200 (2024)Mapped to99+
MED13 and glycolysis are conserved modifiers of alpha-synuclein-associated neurodegeneration.Ren M., Yang Y., Heng K.H.Y., Ng L.Y., Chong C.Y., Ng Y.T., Gorur-Shandilya S., Lee R.M.Q., Lim K.L.[...], Koh T.W.View abstractCategoriesFunctionSourceFlyBase: FBgn0015618PubMedEurope PMCCell Rep 41:111852-111852 (2022)Mapped to99+
Genome-wide phenotypic RNAi screen in the Drosophila wing: phenotypic description of functional classes.Lopez-Varea A., Vega-Cuesta P., Ruiz-Gomez A., Ostale C.M., Molnar C., Hevia C.F., Martin M., Organista M.F., de Celis J.[...], de Celis J.F.View abstractCategoriesFunctionSourceFlyBase: FBgn0015618PubMedEurope PMCG3 (Bethesda) 11:jkab349-jkab349 (2021)Mapped to99+
Functional requirements of protein kinases and phosphatases in the development of the Drosophila melanogaster wing.Ostale C.M., Esteban N., Lopez-Varea A., de Celis J.F.View abstractCategoriesFunctionSourceFlyBase: FBgn0015618PubMedEurope PMCG3 (Bethesda) 11:jkab348-jkab348 (2021)Mapped to99+
Multiplexed conditional genome editing with Cas12a in <i>Drosophila</i>.Port F., Starostecka M., Boutros M.View abstractCategoriesFunction, Phenotypes & VariantsSourceFlyBase: FBgn0015618PubMedEurope PMCProc Natl Acad Sci U S A 117:22890-22899 (2020)Mapped to99+
CRISPR-based modular assembly of a UAS-cDNA/ORF plasmid library for more than 5500 <i>Drosophila</i> genes conserved in humans.Wei P., Xue W., Zhao Y., Ning G., Wang J.View abstractCategoriesFunctionSourceFlyBase: FBgn0015618PubMedEurope PMCGenome Res 30:95-106 (2020)Mapped to99+
Cross-species genetic screens to identify kinase targets for APP reduction in Alzheimer's disease.Huichalaf C.H., Al-Ramahi I., Park K.W., Grunke S.D., Lu N., de Haro M., El-Zein K., Gallego-Flores T., Perez A.M.[...], Jankowsky J.L.View abstractCategoriesFunctionSourceFlyBase: FBgn0015618PubMedEurope PMCHum Mol Genet 28:2014-2029 (2019)Mapped to99+
Time-resolved mapping of genetic interactions to model rewiring of signaling pathways.Heigwer F., Scheeder C., Miersch T., Schmitt B., Blass C., Pour Jamnani M.V., Boutros M.View abstractCategoriesFunctionSourceFlyBase: FBgn0015618PubMedEurope PMCElife 7:e40174-e40174 (2018)Mapped to99+
The TORC1-Regulated CPA Complex Rewires an RNA Processing Network to Drive Autophagy and Metabolic Reprogramming.Tang H.W., Hu Y., Chen C.L., Xia B., Zirin J., Yuan M., Asara J.M., Rabinow L., Perrimon N.View abstractCategoriesFunctionSourceFlyBase: FBgn0015618PubMedEurope PMCCell Metab 27:1040-1054.e8 (2018)Mapped to93
One signal stimulates different transcriptional activation mechanisms.Mazina M.Y., Kovalenko E.V., Derevyanko P.K., Nikolenko J.V., Krasnov A.N., Vorobyeva N.E.View abstractCategoriesFunction, Phenotypes & VariantsSourceFlyBase: FBgn0015618PubMedEurope PMCBiochim Biophys Acta Gene Regul Mech 1861:178-189 (2018)Mapped to58
LRRK2(I2020T) functional genetic interactors that modify eye degeneration and dopaminergic cell loss in Drosophila.Marcogliese P.C., Abuaish S., Kabbach G., Abdel-Messih E., Seang S., Li G., Slack R.S., Haque M.E., Venderova K., Park D.S.View abstractCategoriesFunctionSourceFlyBase: FBgn0015618PubMedEurope PMCHum Mol Genet 26:1247-1257 (2017)Mapped to99+
Functional interplay between MSL1 and CDK7 controls RNA polymerase II Ser5 phosphorylation.Chlamydas S., Holz H., Samata M., Chelmicki T., Georgiev P., Pelechano V., Duendar F., Dasmeh P., Mittler G.[...], Akhtar A.View abstractCategoriesFunction, PTM / Processing, InteractionSourceFlyBase: FBgn0015618PubMedEurope PMCNat. Struct. Mol. Biol. 23:580-589 (2016)Cited in2Mapped to47
Proteome-wide dataset supporting the study of ancient metazoan macromolecular complexes.Phanse S., Wan C., Borgeson B., Tu F., Drew K., Clark G., Xiong X., Kagan O., Kwan J.[...], Emili A.View abstractCategoriesFunction, InteractionSourceFlyBase: FBgn0015618PubMedEurope PMCData Brief 6:715-721 (2016)Mapped to99+
Hedgehog Signaling Strength Is Orchestrated by the mir-310 Cluster of MicroRNAs in Response to Diet.Cicek I.O., Karaca S., Brankatschk M., Eaton S., Urlaub H., Shcherbata H.R.View abstractCategoriesFunctionSourceFlyBase: FBgn0015618PubMedEurope PMCGenetics 202:1167-1183 (2016)Mapped to99+
Transient junction anisotropies orient annular cell polarization in the Drosophila airway tubes.Hosono C., Matsuda R., Adryan B., Samakovlis C.View abstractCategoriesFunction, Subcellular LocationSourceFlyBase: FBgn0015618PubMedEurope PMCNat Cell Biol 17:1569-1576 (2015)Mapped to99+
CDK8-Cyclin C Mediates Nutritional Regulation of Developmental Transitions through the Ecdysone Receptor in Drosophila.Xie X.J., Hsu F.N., Gao X., Xu W., Ni J.Q., Xing Y., Huang L., Hsiao H.C., Zheng H.[...], Ji J.Y.View abstractAnnotationDuring the larval-pupal transition the levels of CDK8 protein positively correlate with EcR and USP levels.CategoriesFunction, InteractionSourceFlyBase: FBgn0015618, GeneRif: 39157PubMedEurope PMCPLoS Biol 13:e1002207-e1002207 (2015)Mapped to99+
P-TEFb, the super elongation complex and mediator regulate a subset of non-paused genes during early Drosophila embryo development.Dahlberg O., Shilkova O., Tang M., Holmqvist P.H., Mannervik M.View abstractCategoriesFunctionSourceFlyBase: FBgn0015618PubMedEurope PMCPLoS Genet 11:e1004971-e1004971 (2015)Mapped to73
Ecdysone and mediator change energy metabolism to terminate proliferation in Drosophila neural stem cells.Homem C.C.F., Steinmann V., Burkard T.R., Jais A., Esterbauer H., Knoblich J.A.View abstractCategoriesFunctionSourceFlyBase: FBgn0015618PubMedEurope PMCCell 158:874-888 (2014)Mapped to87
Cyclin-dependent kinase 8 module expression profiling reveals requirement of mediator subunits 12 and 13 for transcription of Serpent-dependent innate immunity genes in Drosophila.Kuuluvainen E., Hakala H., Havula E., Sahal Estime M., Ramet M., Hietakangas V., Makela T.P.View abstractCategoriesFunctionSourceFlyBase: FBgn0015618PubMedEurope PMCJ Biol Chem 289:16252-16261 (2014)Mapped to99+
A screen for morphological complexity identifies regulators of switch-like transitions between discrete cell shapes.Yin Z., Sadok A., Sailem H., McCarthy A., Xia X., Li F., Garcia M.A., Evans L., Barr A.R.[...], Bakal C.View abstractCategoriesFunction, SequencesSourceFlyBase: FBgn0015618PubMedEurope PMCNat Cell Biol 15:860-871 (2013)Mapped to99+
Systematic screening of a Drosophila ORF library in vivo uncovers Wnt/Wg pathway components.Schertel C., Huang D., Bjorklund M., Bischof J., Yin D., Li R., Wu Y., Zeng R., Wu J.[...], Basler K.View abstractCategoriesFunction, Phenotypes & VariantsSourceFlyBase: FBgn0015618PubMedEurope PMCDev Cell 25:207-219 (2013)Mapped to99+
Transcriptional networks controlling the cell cycle.Bonke M., Turunen M., Sokolova M., Vaharautio A., Kivioja T., Taipale M., Bjorklund M., Taipale J.View abstractCategoriesFunctionSourceFlyBase: FBgn0015618PubMedEurope PMCG3 (Bethesda) 3:75-90 (2013)Mapped to99+
Identification of genetic suppressors of the Sin3A knockdown wing phenotype.Swaminathan A., Barnes V.L., Fox S., Gammouh S., Pile L.A.View abstractCategoriesFunctionSourceFlyBase: FBgn0015618PubMedEurope PMCPLoS One 7:e49563-e49563 (2012)Mapped to99+