Q9VSH0 · CGASL_DROME

Function

function

Probable nucleotidyltransferase that catalyzes the formation of cyclic dinucleotide second messenger in response to some unknown stimulus (By similarity).
Does not catalyze the formation of cyclic GMP-AMP from ATP and GTP (PubMed:34261128).

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Activity regulation

Activated in response of some unknown stimulus (PubMed:29924997).
Not activated in response to L-monocytogenes infection (PubMed:29924997).

Features

Showing features for binding site.

134650100150200250300
TypeIDPosition(s)Description
Binding site58ATP (UniProtKB | ChEBI)
Binding site70Mg2+ (UniProtKB | ChEBI); catalytic
Binding site70-72ATP (UniProtKB | ChEBI)
Binding site72Mg2+ (UniProtKB | ChEBI); catalytic
Binding site165GTP (UniProtKB | ChEBI)
Binding site165Mg2+ (UniProtKB | ChEBI); catalytic
Binding site212-219GTP (UniProtKB | ChEBI)
Binding site216-219ATP (UniProtKB | ChEBI)
Binding site237ATP (UniProtKB | ChEBI)
Binding site252-256ATP (UniProtKB | ChEBI)

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Molecular FunctionATP binding
Molecular FunctionGTP binding
Molecular Functionmetal ion binding
Molecular Functionnucleotidyltransferase activity
Biological Processcopper ion homeostasis

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Cyclic GMP-AMP synthase-like protein
  • EC number

Gene names

    • ORF names
      CG7194

Organism names

  • Taxonomic identifier
  • Strain
    • Berkeley
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Brachycera > Muscomorpha > Ephydroidea > Drosophilidae > Drosophila > Sophophora

Accessions

  • Primary accession
    Q9VSH0

Proteomes

Organism-specific databases

Phenotypes & Variants

Disruption phenotype

Flies display a normal antiviral immune response.

Features

Showing features for mutagenesis.

TypeIDPosition(s)Description
Mutagenesis70-72No effect on antiviral immune response.

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00004544431-346Cyclic GMP-AMP synthase-like protein

Proteomic databases

Expression

Gene expression databases

    • FBgn0035868Expressed in adult midgut (Drosophila) and 23 other cell types or tissues

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Belongs to the mab-21 family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    346
  • Mass (Da)
    40,294
  • Last updated
    2000-05-01 v1
  • Checksum
    841B6ED5947EAAEE
MSTANHFQRILEKLSISDNERAVYTKEAEEIQNYVVDELKRVDKTFRQVFDGLSLGGSYLDRVKLNLPDEFDLHMKLKFPFDIRPTRIDQGFIYLEADLTVINPQRIHRIVLQDWLRNAFRKVFRSNQTIATTSNRVYKLTYTLEGYGCAHTILAVCGSRSISFDLVPAFEFSGSQWPFDICPVPADVSNNWPWFAIPQQKKKSAKPRTTFMVCAPHWEREIMKGKDNLKNVLRLMKGLRDAHARKLPHLSSYMLKTVLLHRLESADWERDLGTLLVEMWSHLVDHLRARRLEFFLAKDHNVFNRMNQNEIKICLENASTLLRKLCIAQTCGGSYHHVAQLFNIPN

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AE014296
EMBL· GenBank· DDBJ
AAF50449.1
EMBL· GenBank· DDBJ
Genomic DNA
BT022230
EMBL· GenBank· DDBJ
AAY54646.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

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