Q9VSH0 · CGASL_DROME
- ProteinCyclic GMP-AMP synthase-like protein
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids346 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
function
Probable nucleotidyltransferase that catalyzes the formation of cyclic dinucleotide second messenger in response to some unknown stimulus (By similarity).
Does not catalyze the formation of cyclic GMP-AMP from ATP and GTP (PubMed:34261128).
Does not catalyze the formation of cyclic GMP-AMP from ATP and GTP (PubMed:34261128).
Cofactor
Mn2+ (UniProtKB | Rhea| CHEBI:29035 )
Activity regulation
Activated in response of some unknown stimulus (PubMed:29924997).
Not activated in response to L-monocytogenes infection (PubMed:29924997).
Not activated in response to L-monocytogenes infection (PubMed:29924997).
Features
Showing features for binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 58 | ATP (UniProtKB | ChEBI) | ||||
Sequence: S | ||||||
Binding site | 70 | Mg2+ (UniProtKB | ChEBI); catalytic | ||||
Sequence: E | ||||||
Binding site | 70-72 | ATP (UniProtKB | ChEBI) | ||||
Sequence: EFD | ||||||
Binding site | 72 | Mg2+ (UniProtKB | ChEBI); catalytic | ||||
Sequence: D | ||||||
Binding site | 165 | GTP (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 165 | Mg2+ (UniProtKB | ChEBI); catalytic | ||||
Sequence: D | ||||||
Binding site | 212-219 | GTP (UniProtKB | ChEBI) | ||||
Sequence: MVCAPHWE | ||||||
Binding site | 216-219 | ATP (UniProtKB | ChEBI) | ||||
Sequence: PHWE | ||||||
Binding site | 237 | ATP (UniProtKB | ChEBI) | ||||
Sequence: K | ||||||
Binding site | 252-256 | ATP (UniProtKB | ChEBI) | ||||
Sequence: SYMLK |
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Molecular Function | ATP binding | |
Molecular Function | GTP binding | |
Molecular Function | metal ion binding | |
Molecular Function | nucleotidyltransferase activity | |
Biological Process | copper ion homeostasis |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameCyclic GMP-AMP synthase-like protein
- EC number
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Brachycera > Muscomorpha > Ephydroidea > Drosophilidae > Drosophila > Sophophora
Accessions
- Primary accessionQ9VSH0
Proteomes
Organism-specific databases
Phenotypes & Variants
Disruption phenotype
Flies display a normal antiviral immune response.
Features
Showing features for mutagenesis.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Mutagenesis | 70-72 | No effect on antiviral immune response. | ||||
Sequence: EFD → AFA |
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000454443 | 1-346 | Cyclic GMP-AMP synthase-like protein | |||
Sequence: MSTANHFQRILEKLSISDNERAVYTKEAEEIQNYVVDELKRVDKTFRQVFDGLSLGGSYLDRVKLNLPDEFDLHMKLKFPFDIRPTRIDQGFIYLEADLTVINPQRIHRIVLQDWLRNAFRKVFRSNQTIATTSNRVYKLTYTLEGYGCAHTILAVCGSRSISFDLVPAFEFSGSQWPFDICPVPADVSNNWPWFAIPQQKKKSAKPRTTFMVCAPHWEREIMKGKDNLKNVLRLMKGLRDAHARKLPHLSSYMLKTVLLHRLESADWERDLGTLLVEMWSHLVDHLRARRLEFFLAKDHNVFNRMNQNEIKICLENASTLLRKLCIAQTCGGSYHHVAQLFNIPN |
Proteomic databases
Expression
Gene expression databases
Structure
Sequence
- Sequence statusComplete
- Length346
- Mass (Da)40,294
- Last updated2000-05-01 v1
- Checksum841B6ED5947EAAEE
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AE014296 EMBL· GenBank· DDBJ | AAF50449.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BT022230 EMBL· GenBank· DDBJ | AAY54646.1 EMBL· GenBank· DDBJ | mRNA |