Q9VRN5 · LIN28_DROME
- ProteinProtein lin-28 homolog
- Genelin-28
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids195 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score5/5
Function
Features
Showing features for binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 127 | Zn2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 130 | Zn2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 136 | Zn2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Binding site | 141 | Zn2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 150 | Zn2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 153 | Zn2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 158 | Zn2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Binding site | 163 | Zn2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: C |
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | cytoplasmic stress granule | |
Cellular Component | cytosol | |
Cellular Component | nucleus | |
Molecular Function | mRNA 3'-UTR binding | |
Molecular Function | mRNA binding | |
Molecular Function | zinc ion binding | |
Biological Process | 3'-UTR-mediated mRNA stabilization | |
Biological Process | germ-line stem-cell niche homeostasis | |
Biological Process | negative regulation of pre-miRNA processing | |
Biological Process | oogenesis | |
Biological Process | positive regulation of insulin receptor signaling pathway | |
Biological Process | positive regulation of receptor signaling pathway via JAK-STAT | |
Biological Process | positive regulation of stem cell proliferation | |
Biological Process | post-embryonic digestive tract morphogenesis | |
Biological Process | post-transcriptional regulation of gene expression | |
Biological Process | pre-miRNA processing | |
Biological Process | symmetric stem cell division |
Keywords
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameProtein lin-28 homolog
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Brachycera > Muscomorpha > Ephydroidea > Drosophilidae > Drosophila > Sophophora
Accessions
- Primary accessionQ9VRN5
Proteomes
Organism-specific databases
Subcellular Location
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000253797 | 1-195 | Protein lin-28 homolog | |||
Sequence: MENVQLENGLERRTTSQSSTSSANPANLASPTEECGCVRLGKCKWFNVAKGWGFLTPNDGGQEVFVHQSVIQMSGFRSLGEQEEVEFECQRTSRGLEATRVSSRHGGSCQGSTYRPRINRRTRRMRCYNCGEFANHIASECALGPQPKRCHRCRGEDHLHADCPHKNVTQSHSNSKSISNNSSSSAAQEKSEEAT |
Proteomic databases
Expression
Developmental stage
Expressed from embryogenesis to the first instar larval stage, then at the pupal stage. Not expressed at significant levels in the adult.
Gene expression databases
Structure
Family & Domains
Features
Showing features for compositional bias, region, domain, zinc finger.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 1-29 | Polar residues | ||||
Sequence: MENVQLENGLERRTTSQSSTSSANPANLA | ||||||
Region | 1-31 | Disordered | ||||
Sequence: MENVQLENGLERRTTSQSSTSSANPANLASP | ||||||
Domain | 38-104 | CSD | ||||
Sequence: VRLGKCKWFNVAKGWGFLTPNDGGQEVFVHQSVIQMSGFRSLGEQEEVEFECQRTSRGLEATRVSSR | ||||||
Zinc finger | 126-143 | CCHC-type 1 | ||||
Sequence: RCYNCGEFANHIASECAL | ||||||
Zinc finger | 148-165 | CCHC-type 2 | ||||
Sequence: KRCHRCRGEDHLHADCPH | ||||||
Region | 164-195 | Disordered | ||||
Sequence: PHKNVTQSHSNSKSISNNSSSSAAQEKSEEAT | ||||||
Compositional bias | 166-195 | Polar residues | ||||
Sequence: KNVTQSHSNSKSISNNSSSSAAQEKSEEAT |
Sequence similarities
Belongs to the lin-28 family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length195
- Mass (Da)21,594
- Last updated2002-10-01 v2
- Checksum4F2E080F20137EA5
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 1-29 | Polar residues | ||||
Sequence: MENVQLENGLERRTTSQSSTSSANPANLA | ||||||
Compositional bias | 166-195 | Polar residues | ||||
Sequence: KNVTQSHSNSKSISNNSSSSAAQEKSEEAT |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AF521096 EMBL· GenBank· DDBJ | AAM77748.1 EMBL· GenBank· DDBJ | mRNA | ||
AE014296 EMBL· GenBank· DDBJ | AAF50758.2 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY118360 EMBL· GenBank· DDBJ | AAM48389.1 EMBL· GenBank· DDBJ | mRNA |