Q9VR20 · OTUD_DROME
- ProteinOTU domain-containing protein CG3251
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids495 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score3/5
Function
function
Putative OTU-type deubiquitinase (PubMed:26588485).
Catalytically inactive towards all diubiquitin molecules and long K48- and K63- linked ubiquitin chains in vitro (PubMed:26588485).
Potential modulator of apoptosis (PubMed:26588485).
Catalytically inactive towards all diubiquitin molecules and long K48- and K63- linked ubiquitin chains in vitro (PubMed:26588485).
Potential modulator of apoptosis (PubMed:26588485).
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Molecular Function | deubiquitinase activity | |
Molecular Function | serine-type peptidase activity | |
Biological Process | apoptotic process | |
Biological Process | regulation of apoptotic process |
Keywords
- Biological process
Protein family/group databases
Names & Taxonomy
Protein names
- Recommended nameOTU domain-containing protein CG3251
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Brachycera > Muscomorpha > Ephydroidea > Drosophilidae > Drosophila > Sophophora
Accessions
- Primary accessionQ9VR20
Proteomes
Organism-specific databases
Phenotypes & Variants
Features
Showing features for mutagenesis.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Mutagenesis | 40 | Does not rescue in vitro deubiquitinase activity. | ||||
Sequence: S → C |
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000460777 | 1-495 | OTU domain-containing protein CG3251 | |||
Sequence: MSEVLQRLASTEVRKARDPIDRFLERRQLFRKHMLGDASSLFRVVAEQVYDTQMLHYEVRMECVRYMFTKWKTFRRFVSGDFDEYLWHLGKTKTAGTILELGAMCHLYRRNVIIYEPFDMGRMVTYNKDYKEILRIFMNSMGHFETVLTMQDVDMAAVCQSVSFKMLYKHLFRLPDVDLAVEWMLYPDTFKMGTEYEFDSRGRAIRLLCRNGRSFKLDRPESTICLLENSQMCPFHNRRLAMGGQFADFSCMRILLEENNIPFSYLVAKSMDPCRYRNVELTSAIEARREAYEFGIYIGDYNFKVGAKCQVQLDTNRRDLLSACYIQSIDKKKSVCKVFIEEQGKLVDVPSDNLHPLPPDEFKAWDFARKRPQRLHNSQMGRQSVQGDQQGFVPDPMPGTAPSMPPPPVADPRPVNVTAQQPPVFGPSRWMEPTRPLMPNPLMIHQTGSFVFVQQPRVGPPSVMMHVLIIVHNAPYMLAFDHAPHPPAPQCTAPF |
Proteomic databases
Expression
Gene expression databases
Structure
Family & Domains
Features
Showing features for domain, region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 29-150 | OTU | ||||
Sequence: LFRKHMLGDASSLFRVVAEQVYDTQMLHYEVRMECVRYMFTKWKTFRRFVSGDFDEYLWHLGKTKTAGTILELGAMCHLYRRNVIIYEPFDMGRMVTYNKDYKEILRIFMNSMGHFETVLTM | ||||||
Domain | 302-364 | Tudor | ||||
Sequence: NFKVGAKCQVQLDTNRRDLLSACYIQSIDKKKSVCKVFIEEQGKLVDVPSDNLHPLPPDEFKA | ||||||
Region | 375-404 | Disordered | ||||
Sequence: LHNSQMGRQSVQGDQQGFVPDPMPGTAPSM |
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length495
- Mass (Da)57,417
- Last updated2000-05-01 v1
- ChecksumADF4203D1A3A4FC3
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AE014134 EMBL· GenBank· DDBJ | AAF50988.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BT031300 EMBL· GenBank· DDBJ | ABY20541.1 EMBL· GenBank· DDBJ | mRNA |