Q9VPD3 · PTSS_DROME
- ProteinPhosphatidylserine synthase
- GenePss
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids498 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Catalyzes a base-exchange reaction in which the polar head group of phosphatidylethanolamine (PE) is replaced by L-serine.
Catalytic activity
- a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + L-serine = a 1,2-diacyl-sn-glycero-3-phospho-L-serine + ethanolamine
Pathway
Phospholipid metabolism; phosphatidylserine biosynthesis.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | endomembrane system | |
Cellular Component | endoplasmic reticulum membrane | |
Molecular Function | L-serine-phosphatidylcholine phosphatidyltransferase activity | |
Molecular Function | L-serine-phosphatidylethanolamine phosphatidyltransferase activity | |
Molecular Function | phosphotransferase activity, for other substituted phosphate groups | |
Biological Process | phosphatidylserine biosynthetic process |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namePhosphatidylserine synthase
- EC number
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Brachycera > Muscomorpha > Ephydroidea > Drosophilidae > Drosophila > Sophophora
Accessions
- Primary accessionQ9VPD3
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Endoplasmic reticulum membrane ; Multi-pass membrane protein
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 1-92 | Cytoplasmic | ||||
Sequence: MKKRTNSRGTPTSSGDALLDTSFSSAGDAERDHPAYKSGAASAPATPTKRRDGSDGSVSSAGARRKRKDEIAQTFVIVNERPVDDISLDFFY | ||||||
Transmembrane | 93-113 | Helical | ||||
Sequence: KPHTITLLAVSVLAVMYFAFV | ||||||
Topological domain | 114-122 | Lumenal | ||||
Sequence: RNEANVDEN | ||||||
Transmembrane | 123-143 | Helical | ||||
Sequence: LWAGLLCIVFFFLIVSVIAFP | ||||||
Topological domain | 144-153 | Cytoplasmic | ||||
Sequence: NGPFTRPHPA | ||||||
Transmembrane | 154-174 | Helical | ||||
Sequence: VWRILFGCSVLYLLTLQFLMF | ||||||
Topological domain | 175-239 | Lumenal | ||||
Sequence: QNYPTIRSIFYWIDPKLKNFHIDMEKEYGVNCSDISWDRVKGHLDVFAWGHFLGWAFKAILIRHM | ||||||
Transmembrane | 240-260 | Helical | ||||
Sequence: GILWAISVMWEITEITFAHLL | ||||||
Topological domain | 261-266 | Cytoplasmic | ||||
Sequence: PNFIEC | ||||||
Transmembrane | 267-287 | Helical | ||||
Sequence: WWDALILDVIICNGLGIWMGL | ||||||
Topological domain | 288-339 | Lumenal | ||||
Sequence: KICQILEMREYKWASIKDISTTTGKIKRAMLQFTPESWSAIRWLDPKSTAMR | ||||||
Transmembrane | 340-360 | Helical | ||||
Sequence: FAAVIQLVIFWQVTELNTFFL | ||||||
Topological domain | 361-367 | Cytoplasmic | ||||
Sequence: KHIFEMP | ||||||
Transmembrane | 368-388 | Helical | ||||
Sequence: PDHFIVIGRLIFIGLFVAPSV | ||||||
Topological domain | 389-402 | Lumenal | ||||
Sequence: RQYYVYVTDTRCKR | ||||||
Transmembrane | 403-423 | Helical | ||||
Sequence: VGTQCWVYGAIMVSEAILCIK | ||||||
Topological domain | 424-436 | Cytoplasmic | ||||
Sequence: NGKELFERTQAIN | ||||||
Transmembrane | 437-457 | Helical | ||||
Sequence: IVLWLTVQVIISVAFVYLAVY | ||||||
Topological domain | 458-498 | Lumenal | ||||
Sequence: WQQRQLKKVSSTPAKTKETIPASSSSPSKGKLSPQKEKKLK |
Keywords
- Cellular component
Phenotypes & Variants
Disruption phenotype
Lethal at the first instar larval stage (PubMed:31869331).
RNAi-mediated knockdown in salivary glands reduces phosphatidylserine (PS) levels and depletes Akt1 from the plasma membrane contributing to cell growth defects probably by affecting the insulin pathway; causes a shift from phospholipid synthesis to neutral lipid synthesis, which results in ectopic lipid accumulation in third instar larval salivary glands; reduces mitochondrial PS levels thereby impairing mitochondrial protein import and mitochondrial integrity (PubMed:31869331).
RNAi-mediated knockdown in salivary glands reduces phosphatidylserine (PS) levels and depletes Akt1 from the plasma membrane contributing to cell growth defects probably by affecting the insulin pathway; causes a shift from phospholipid synthesis to neutral lipid synthesis, which results in ectopic lipid accumulation in third instar larval salivary glands; reduces mitochondrial PS levels thereby impairing mitochondrial protein import and mitochondrial integrity (PubMed:31869331).
PTM/Processing
Features
Showing features for chain, glycosylation.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000450822 | 1-498 | Phosphatidylserine synthase | |||
Sequence: MKKRTNSRGTPTSSGDALLDTSFSSAGDAERDHPAYKSGAASAPATPTKRRDGSDGSVSSAGARRKRKDEIAQTFVIVNERPVDDISLDFFYKPHTITLLAVSVLAVMYFAFVRNEANVDENLWAGLLCIVFFFLIVSVIAFPNGPFTRPHPAVWRILFGCSVLYLLTLQFLMFQNYPTIRSIFYWIDPKLKNFHIDMEKEYGVNCSDISWDRVKGHLDVFAWGHFLGWAFKAILIRHMGILWAISVMWEITEITFAHLLPNFIECWWDALILDVIICNGLGIWMGLKICQILEMREYKWASIKDISTTTGKIKRAMLQFTPESWSAIRWLDPKSTAMRFAAVIQLVIFWQVTELNTFFLKHIFEMPPDHFIVIGRLIFIGLFVAPSVRQYYVYVTDTRCKRVGTQCWVYGAIMVSEAILCIKNGKELFERTQAINIVLWLTVQVIISVAFVYLAVYWQQRQLKKVSSTPAKTKETIPASSSSPSKGKLSPQKEKKLK | ||||||
Glycosylation | 205 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N |
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Gene expression databases
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-65 | Disordered | ||||
Sequence: MKKRTNSRGTPTSSGDALLDTSFSSAGDAERDHPAYKSGAASAPATPTKRRDGSDGSVSSAGARR | ||||||
Compositional bias | 7-21 | Polar residues | ||||
Sequence: SRGTPTSSGDALLDT | ||||||
Compositional bias | 465-488 | Polar residues | ||||
Sequence: KVSSTPAKTKETIPASSSSPSKGK | ||||||
Region | 465-498 | Disordered | ||||
Sequence: KVSSTPAKTKETIPASSSSPSKGKLSPQKEKKLK |
Sequence similarities
Belongs to the phosphatidyl serine synthase family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence & Isoform
- Sequence statusComplete
This entry describes 2 isoforms produced by Alternative splicing.
Q9VPD3-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- NameA
- Length498
- Mass (Da)56,835
- Last updated2000-05-01 v1
- Checksum617134A5D78F028E
Q9VPD3-2
- NameB
- Differences from canonical
- 459-459: Missing
Features
Showing features for compositional bias, alternative sequence.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 7-21 | Polar residues | ||||
Sequence: SRGTPTSSGDALLDT | ||||||
Alternative sequence | VSP_060726 | 459 | in isoform B | |||
Sequence: Missing | ||||||
Compositional bias | 465-488 | Polar residues | ||||
Sequence: KVSSTPAKTKETIPASSSSPSKGK |
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AE014296 EMBL· GenBank· DDBJ | AAF51622.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AE014296 EMBL· GenBank· DDBJ | AGB94811.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY069402 EMBL· GenBank· DDBJ | AAL39547.1 EMBL· GenBank· DDBJ | mRNA |