Q9VNK9 · OR83C_DROME
- ProteinPutative odorant receptor 83c
- GeneOr83c
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids397 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score3/5
Function
function
Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration. May form a complex with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability (By similarity).
Miscellaneous
The atypical heteromeric and topological design of the odorant receptors appears to be an insect-specific solution for odor recognition, making the OR/Orco complex an attractive target for the development of highly selective insect repellents to disrupt olfactory-mediated host-seeking behaviors of insect disease vectors. Odor-evoked OR currents are independent of known G-protein-coupled second messenger pathways.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cation channel complex | |
Cellular Component | dendrite membrane | |
Cellular Component | plasma membrane | |
Molecular Function | ionotropic olfactory receptor activity | |
Molecular Function | odorant binding | |
Molecular Function | olfactory receptor activity | |
Biological Process | detection of chemical stimulus involved in sensory perception of smell | |
Biological Process | signal transduction |
Keywords
- Molecular function
- Biological process
Names & Taxonomy
Protein names
- Recommended namePutative odorant receptor 83c
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Brachycera > Muscomorpha > Ephydroidea > Drosophilidae > Drosophila > Sophophora
Accessions
- Primary accessionQ9VNK9
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Multi-pass membrane protein
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 1-39 | Cytoplasmic | ||||
Sequence: MSTSESPSSRFRELSKYINSLTNLLGVDFLSPKLKFNYR | ||||||
Transmembrane | 40-60 | Helical; Name=1 | ||||
Sequence: TWTTIFAIANYTGFTVFTILN | ||||||
Topological domain | 61-70 | Extracellular | ||||
Sequence: NGGDWRVGLK | ||||||
Transmembrane | 71-90 | Helical; Name=2 | ||||
Sequence: ASLMTGGLFHGLGKFLTCLL | ||||||
Topological domain | 91-136 | Cytoplasmic | ||||
Sequence: KHQDMRRLVLYSQSIYDEYETRGDSYHRTLNSNIDRLLGIMKIIRN | ||||||
Transmembrane | 137-157 | Helical; Name=3 | ||||
Sequence: GYVFAFCLMELLPLAMLMYDG | ||||||
Topological domain | 158-186 | Extracellular | ||||
Sequence: TRVTAMQYLIPGLPLENNYCYVVTYMIQT | ||||||
Transmembrane | 187-207 | Helical; Name=4 | ||||
Sequence: VTMLVQGVGFYSGDLFVFLGL | ||||||
Topological domain | 208-282 | Cytoplasmic | ||||
Sequence: TQILTFADMLQVKVKELNDALEQKAEYRALVRVGASIDGAENRQRLLLDVIRWHQLFTDYCRAINALYYELIATQ | ||||||
Transmembrane | 283-299 | Helical; Name=5 | ||||
Sequence: VLSMALAMMLSFCINLS | ||||||
Topological domain | 300-305 | Extracellular | ||||
Sequence: SFHMPS | ||||||
Transmembrane | 306-326 | Helical; Name=6 | ||||
Sequence: AIFFVVSAYSMSIYCILGTIL | ||||||
Topological domain | 327-365 | Cytoplasmic | ||||
Sequence: EFAYDQVYESICNVTWYELSGEQRKLFGFLLRESQYPHN | ||||||
Transmembrane | 366-386 | Helical; Name=7 | ||||
Sequence: IQILGVMSLSVRTALQIVKLI | ||||||
Topological domain | 387-397 | Extracellular | ||||
Sequence: YSVSMMMMNRA |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000174273 | 1-397 | Putative odorant receptor 83c | |||
Sequence: MSTSESPSSRFRELSKYINSLTNLLGVDFLSPKLKFNYRTWTTIFAIANYTGFTVFTILNNGGDWRVGLKASLMTGGLFHGLGKFLTCLLKHQDMRRLVLYSQSIYDEYETRGDSYHRTLNSNIDRLLGIMKIIRNGYVFAFCLMELLPLAMLMYDGTRVTAMQYLIPGLPLENNYCYVVTYMIQTVTMLVQGVGFYSGDLFVFLGLTQILTFADMLQVKVKELNDALEQKAEYRALVRVGASIDGAENRQRLLLDVIRWHQLFTDYCRAINALYYELIATQVLSMALAMMLSFCINLSSFHMPSAIFFVVSAYSMSIYCILGTILEFAYDQVYESICNVTWYELSGEQRKLFGFLLRESQYPHNIQILGVMSLSVRTALQIVKLIYSVSMMMMNRA |
Proteomic databases
Expression
Tissue specificity
Expressed in olfactory sensory neurons in the antenna.
Gene expression databases
Structure
Family & Domains
Sequence similarities
Belongs to the insect chemoreceptor superfamily. Heteromeric odorant receptor channel (TC 1.A.69) family. Or67d subfamily.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length397
- Mass (Da)45,487
- Last updated2001-06-01 v2
- Checksum59CA3EF415BB711A
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AE014297 EMBL· GenBank· DDBJ | AAF51921.2 EMBL· GenBank· DDBJ | Genomic DNA |