Q9VNB5 · ORCO_DROME
- ProteinOdorant receptor coreceptor
- GeneOrco
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids486 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Odorant coreceptor which complexes with conventional odorant receptors (ORs) to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability. Orco is a universal and integral part of the functional odorant receptor, involved in the dendritic localization of other olfactory receptors. Expression of Orco alone leads to formation of rapid and transient ion channels not directly responding to odorants, but directly activated by intracellular cAMP or cGMP. Snmp, Or67d and lush act in concert to capture fatty-acid-derived male pheromone 11-cis vaccenyl acetate (cVA) molecules on the surface of Or67d expressing olfactory dendrites and facilitate their transfer to the odorant-receptor Orco complex.
Miscellaneous
The atypical heteromeric and topological design of the odorant receptors appears to be an insect-specific solution for odor recognition, making the OR/Orco complex an attractive target for the development of highly selective insect repellents to disrupt olfactory-mediated host-seeking behaviors of insect disease vectors. Odor-evoked OR currents are independent of known G-protein-coupled second messenger pathways. The homomeric Orco channel is thought to be a cyclic-nucleotide-gated ion channel that depolarizes the olfactory receptor neuron.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cation channel complex | |
Cellular Component | cilium | |
Cellular Component | dendrite | |
Cellular Component | dendrite membrane | |
Cellular Component | plasma membrane | |
Molecular Function | calmodulin binding | |
Molecular Function | coreceptor activity | |
Molecular Function | intracellularly gated calcium channel activity | |
Molecular Function | ionotropic olfactory receptor activity | |
Molecular Function | odorant binding | |
Molecular Function | olfactory receptor activity | |
Molecular Function | protein homodimerization activity | |
Biological Process | behavioral response to ethanol | |
Biological Process | detection of chemical stimulus involved in sensory perception of smell | |
Biological Process | olfactory behavior | |
Biological Process | regulation of protein localization | |
Biological Process | response to pheromone | |
Biological Process | sensory perception of smell |
Keywords
- Molecular function
- Biological process
Protein family/group databases
Names & Taxonomy
Protein names
- Recommended nameOdorant receptor coreceptor
- Alternative names
Gene names
Organism names
- Strains
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Brachycera > Muscomorpha > Ephydroidea > Drosophilidae > Drosophila > Sophophora
Accessions
- Primary accessionQ9VNB5
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Multi-pass membrane protein
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 1-47 | Cytoplasmic | ||||
Sequence: MTTSMQPSKYTGLVADLMPNIRAMKYSGLFMHNFTGGSAFMKKVYSS | ||||||
Transmembrane | 48-68 | Helical; Name=1 | ||||
Sequence: VHLVFLLMQFTFILVNMALNA | ||||||
Topological domain | 69-75 | Extracellular | ||||
Sequence: EEVNELS | ||||||
Transmembrane | 76-96 | Helical; Name=2 | ||||
Sequence: GNTITTLFFTHCITKFIYLAV | ||||||
Topological domain | 97-135 | Cytoplasmic | ||||
Sequence: NQKNFYRTLNIWNQVNTHPLFAESDARYHSIALAKMRKL | ||||||
Transmembrane | 136-156 | Helical; Name=3 | ||||
Sequence: FFLVMLTTVASATAWTTITFF | ||||||
Topological domain | 157-191 | Extracellular | ||||
Sequence: GDSVKMVVDHETNSSIPVEIPRLPIKSFYPWNASH | ||||||
Transmembrane | 192-212 | Helical; Name=4 | ||||
Sequence: GMFYMISFAFQIYYVLFSMIH | ||||||
Topological domain | 213-351 | Cytoplasmic | ||||
Sequence: SNLCDVMFCSWLIFACEQLQHLKGIMKPLMELSASLDTYRPNSAALFRSLSANSKSELIHNEEKDPGTDMDMSGIYSSKADWGAQFRAPSTLQSFGGNGGGGNGLVNGANPNGLTKKQEMMVRSAIKYWVERHKHVVRL | ||||||
Transmembrane | 352-372 | Helical; Name=5 | ||||
Sequence: VAAIGDTYGAALLLHMLTSTI | ||||||
Topological domain | 373-390 | Extracellular | ||||
Sequence: KLTLLAYQATKINGVNVY | ||||||
Transmembrane | 391-411 | Helical; Name=6 | ||||
Sequence: AFTVVGYLGYALAQVFHFCIF | ||||||
Topological domain | 412-462 | Cytoplasmic | ||||
Sequence: GNRLIEESSSVMEAAYSCHWYDGSEEAKTFVQIVCQQCQKAMSISGAKFFT | ||||||
Transmembrane | 463-483 | Helical; Name=7 | ||||
Sequence: VSLDLFASVLGAVVTYFMVLV | ||||||
Topological domain | 484-486 | Extracellular | ||||
Sequence: QLK |
Keywords
- Cellular component
Phenotypes & Variants
Features
Showing features for natural variant, mutagenesis.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Natural variant | 143 | in strain: Oregon-R | ||||
Sequence: T → I | ||||||
Mutagenesis | 169 | Destroys glycosylation site. | ||||
Sequence: N → NQ |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 1 variant from UniProt as well as other sources including ClinVar and dbSNP.
PTM/Processing
Features
Showing features for chain, glycosylation.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000174272 | 1-486 | Odorant receptor coreceptor | |||
Sequence: MTTSMQPSKYTGLVADLMPNIRAMKYSGLFMHNFTGGSAFMKKVYSSVHLVFLLMQFTFILVNMALNAEEVNELSGNTITTLFFTHCITKFIYLAVNQKNFYRTLNIWNQVNTHPLFAESDARYHSIALAKMRKLFFLVMLTTVASATAWTTITFFGDSVKMVVDHETNSSIPVEIPRLPIKSFYPWNASHGMFYMISFAFQIYYVLFSMIHSNLCDVMFCSWLIFACEQLQHLKGIMKPLMELSASLDTYRPNSAALFRSLSANSKSELIHNEEKDPGTDMDMSGIYSSKADWGAQFRAPSTLQSFGGNGGGGNGLVNGANPNGLTKKQEMMVRSAIKYWVERHKHVVRLVAAIGDTYGAALLLHMLTSTIKLTLLAYQATKINGVNVYAFTVVGYLGYALAQVFHFCIFGNRLIEESSSVMEAAYSCHWYDGSEEAKTFVQIVCQQCQKAMSISGAKFFTVSLDLFASVLGAVVTYFMVLVQLK | ||||||
Glycosylation | 169 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 188 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N |
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Tissue specificity
Expression is restricted to olfactory sensory neurons (OSNs). Coexpressed with Snmp in a lateral-distal population of OSNs. Expressed in the embryonic antennal-maxillary complex, in all 21 OSNs of the larval dorsal organ, in the pupal antennal OSNs, in all 120 adult maxillary palp neurons and in approximately 70-80% of adult antennal OSNs, where expression is highest at the dorsal-medial edge. Localized to OSN cell bodies and to the distal portion of ciliated OSN dendrites.
Developmental stage
Expressed throughout all developmental stages. First expressed at embryonic stage 15. Pupal expression first occurs 80 hours after puparium formation.
Gene expression databases
Interaction
Subunit
Heterodimer with conventional odorant receptors (ORs). Complexes exist early in the endomembrane system in olfactory sensory neurons (OSNs), coupling these complexes to the conserved ciliary trafficking pathway.
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | Intact | |
---|---|---|---|---|---|
BINARY | Q9VNB5 | Or43a P81917 | 2 | EBI-15562228, EBI-15562282 |
Protein-protein interaction databases
Structure
Family & Domains
Sequence similarities
Belongs to the insect chemoreceptor superfamily. Heteromeric odorant receptor channel (TC 1.A.69) family. Orco subfamily.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length486
- Mass (Da)54,413
- Last updated2001-06-01 v2
- Checksum8DD0ACDC3091B5D6
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AY567998 EMBL· GenBank· DDBJ | AAT71306.1 EMBL· GenBank· DDBJ | mRNA | ||
AE014297 EMBL· GenBank· DDBJ | AAF52031.2 EMBL· GenBank· DDBJ | Genomic DNA | ||
AE014297 EMBL· GenBank· DDBJ | ABW08603.1 EMBL· GenBank· DDBJ | Genomic DNA |