Q9VMN5 · CH60C_DROME
- Protein60 kDa heat shock protein homolog 2, mitochondrial
- GeneHsp60C
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids576 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score5/5
Function
function
Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity).
Essential for proper development of trachea, spermatogonia and spermatocytes
Essential for proper development of trachea, spermatogonia and spermatocytes
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | mitochondrial inner membrane | |
Cellular Component | mitochondrial matrix | |
Molecular Function | ATP binding | |
Molecular Function | ATP hydrolysis activity | |
Molecular Function | ATP-dependent protein folding chaperone | |
Molecular Function | protein-folding chaperone binding | |
Biological Process | apoptotic mitochondrial changes | |
Biological Process | female germline ring canal formation | |
Biological Process | follicle cell of egg chamber development | |
Biological Process | mitochondrial unfolded protein response | |
Biological Process | oogenesis | |
Biological Process | open tracheal system development | |
Biological Process | protein folding | |
Biological Process | protein import into mitochondrial intermembrane space | |
Biological Process | protein refolding | |
Biological Process | spermatogenesis |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended name60 kDa heat shock protein homolog 2, mitochondrial
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Brachycera > Muscomorpha > Ephydroidea > Drosophilidae > Drosophila > Sophophora
Accessions
- Primary accessionQ9VMN5
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
Phenotypes & Variants
Disruption phenotype
Flies are male and female sterile; reduction in numbers of primary and secondary spermatocytes.
PTM/Processing
Features
Showing features for transit peptide, chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Transit peptide | 1-61 | Mitochondrion | |||
Chain | PRO_0000005033 | 62-576 | 60 kDa heat shock protein homolog 2, mitochondrial | ||
Proteomic databases
Expression
Tissue specificity
First detectable expression is seen in the posterior part of the dorsal tracheal trunk at stage 14-15, which marks the beginning of terminal tracheation. In the larval gut, expression in proventriculus is stronger than in midgut and hindgut. Malpighian tubules shows low expression and late third instar larval imaginal disks and brain showed moderate expression. In larval ovary and testis, expression is strong in the posterior region.
Developmental stage
Expression first seen in late embryonic stages and continues in larval and adult stages.
Gene expression databases
Structure
Sequence
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
- Length576
- Mass (Da)61,587
- Last updated2004-05-10 v2
- MD5 Checksum7C76E603419A7914D314085B5D337EE0
Features
Showing features for sequence conflict.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Sequence conflict | 160 | in Ref. 3; AAM29278 | |||
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AE014134 EMBL· GenBank· DDBJ | AAF52277.2 EMBL· GenBank· DDBJ | Genomic DNA | ||
AE014134 EMBL· GenBank· DDBJ | AAN10550.2 EMBL· GenBank· DDBJ | Genomic DNA | ||
AE014134 EMBL· GenBank· DDBJ | AAN10551.2 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY113273 EMBL· GenBank· DDBJ | AAM29278.1 EMBL· GenBank· DDBJ | mRNA | ||
BT001308 EMBL· GenBank· DDBJ | AAN71063.1 EMBL· GenBank· DDBJ | mRNA |