Q9VM90 · SBKH_DROME

Function

function

Serine/threonine-protein kinase involved in memory formation. Together with the cAMP-dependent protein kinase A Pka-C1, promotes long-term memory (LTM) by regulating CrebB stability and activity. Involved in the maintenance of anesthesia-sensitive memory (ASM) which includes short-term memory (STM) and middle-term memory (MTM).

Miscellaneous

Meng-Po is the Lady of Forgetfulness, a character in Chinese mythology, who ensures that people are ready for reincarnation by providing the 'Tea of Forgetfulness' that makes them loose the memories associated with their former life.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Activity regulation

Activated by Pka-C1-mediated phosphorylation of Ser-334.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site107-115ATP (UniProtKB | ChEBI)
Binding site130ATP (UniProtKB | ChEBI)
Active site221Proton acceptor

GO annotations

AspectTerm
Molecular FunctionATP binding
Molecular Functionmetal ion binding
Molecular Functionprotein serine kinase activity
Molecular Functionprotein serine/threonine kinase activity
Biological Processlong-term memory
Biological Processmedium-term memory
Biological Processpositive regulation of gene expression
Biological Processshort-term memory

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Serine/threonine-protein kinase meng-po
  • EC number
  • Short names
    meng-po
  • Alternative names
    • SH3-binding kinase homolog

Gene names

    • Name
      meng
    • Synonyms
      MP
      , PKN
    • ORF names
      CG11221

Organism names

  • Taxonomic identifier
  • Strain
    • Berkeley
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Brachycera > Muscomorpha > Ephydroidea > Drosophilidae > Drosophila > Sophophora

Accessions

  • Primary accession
    Q9VM90

Proteomes

Organism-specific databases

Phenotypes & Variants

Disruption phenotype

Results in a decreased CrebB protein translation or stability in the brain. RNAi-mediated knockdown in the mushroom bodies results in a reduction of memory formation, including anesthesia-sensitive memory (ASM) and long-term memory (LTM) performance but not anesthesia-resistant memory (ARM) or learning ability.

Features

Showing features for mutagenesis.

TypeIDPosition(s)Description
Mutagenesis334Abolishes phosphorylation. Reduces kinase activity.

PTM/Processing

Features

Showing features for chain, modified residue.

TypeIDPosition(s)Description
ChainPRO_00004444331-456Serine/threonine-protein kinase meng-po
Modified residue334Phosphoserine; by PKA

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Expressed in the mushroom bodies (at protein level).

Developmental stage

Expressed broadly in the third instar larvae and adult flies (at protein levels).

Gene expression databases

    • FBgn0031855Expressed in oviduct (Drosophila) and 11 other cell types or tissues

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for region, compositional bias, domain.

TypeIDPosition(s)Description
Region15-78Disordered
Compositional bias17-60Polar residues
Domain101-367Protein kinase

Sequence similarities

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    456
  • Mass (Da)
    52,419
  • Last updated
    2000-05-01 v1
  • Checksum
    272D73C6677C375B
MGTIEKRSFSFRLRRSFGDGGSTNSRNSNNNSSTCTNHNNQKRCSTPLTPTSTSTGRLEVPGAASVSRRSSIYKKPDKNDGGQIHLIPDVELPLMTFADQYNIEKTLAEGCFAKILLCRHRPTNTLVVLKAVHAELTTIKEFQKEFHYNYELSHHHHILSAYAVAFQTMDYYVFAMEHAPYGDLASNIGPNGLHENACKLISEQLSSALGFMHSKNLVHRDLKIENILVFTPDFTRVKLCDFGATTKKGLLVHKVKHTWTSCVPPEQLELIKNERFQCLPVSDSWQFGILLYNILTGNPPWQSADWVKDQSYANFMKYEQRKTTKVPDNFRRFSPRLMRCFRKYLSHDPEDRCKITEVAKYMKDRWVECRISTSKSATLISPTNHDQDSCIYLNQREGRLSGDENKLRFKRMMSTYGLDIPIDQAMVRRRVWDWLSTCDANFDPDVESLHALDLLQ

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias17-60Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AE014134
EMBL· GenBank· DDBJ
AAF52433.1
EMBL· GenBank· DDBJ
Genomic DNA
AE014134
EMBL· GenBank· DDBJ
AHN54203.1
EMBL· GenBank· DDBJ
Genomic DNA
AY071597
EMBL· GenBank· DDBJ
AAL49219.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

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