Q9VM90 · SBKH_DROME
- ProteinSerine/threonine-protein kinase meng-po
- Genemeng
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids456 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Serine/threonine-protein kinase involved in memory formation. Together with the cAMP-dependent protein kinase A Pka-C1, promotes long-term memory (LTM) by regulating CrebB stability and activity. Involved in the maintenance of anesthesia-sensitive memory (ASM) which includes short-term memory (STM) and middle-term memory (MTM).
Miscellaneous
Meng-Po is the Lady of Forgetfulness, a character in Chinese mythology, who ensures that people are ready for reincarnation by providing the 'Tea of Forgetfulness' that makes them loose the memories associated with their former life.
Catalytic activity
- ATP + L-seryl-[protein] = ADP + H+ + O-phospho-L-seryl-[protein]
Cofactor
Activity regulation
Activated by Pka-C1-mediated phosphorylation of Ser-334.
Features
Showing features for binding site, active site.
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | ATP binding | |
Molecular Function | metal ion binding | |
Molecular Function | protein serine kinase activity | |
Molecular Function | protein serine/threonine kinase activity | |
Biological Process | long-term memory | |
Biological Process | medium-term memory | |
Biological Process | positive regulation of gene expression | |
Biological Process | short-term memory |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameSerine/threonine-protein kinase meng-po
- EC number
- Short namesmeng-po
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Brachycera > Muscomorpha > Ephydroidea > Drosophilidae > Drosophila > Sophophora
Accessions
- Primary accessionQ9VM90
Proteomes
Organism-specific databases
Phenotypes & Variants
Disruption phenotype
Results in a decreased CrebB protein translation or stability in the brain. RNAi-mediated knockdown in the mushroom bodies results in a reduction of memory formation, including anesthesia-sensitive memory (ASM) and long-term memory (LTM) performance but not anesthesia-resistant memory (ARM) or learning ability.
Features
Showing features for mutagenesis.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Mutagenesis | 334 | Abolishes phosphorylation. Reduces kinase activity. | ||||
Sequence: S → A |
PTM/Processing
Features
Showing features for chain, modified residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000444433 | 1-456 | Serine/threonine-protein kinase meng-po | |||
Sequence: MGTIEKRSFSFRLRRSFGDGGSTNSRNSNNNSSTCTNHNNQKRCSTPLTPTSTSTGRLEVPGAASVSRRSSIYKKPDKNDGGQIHLIPDVELPLMTFADQYNIEKTLAEGCFAKILLCRHRPTNTLVVLKAVHAELTTIKEFQKEFHYNYELSHHHHILSAYAVAFQTMDYYVFAMEHAPYGDLASNIGPNGLHENACKLISEQLSSALGFMHSKNLVHRDLKIENILVFTPDFTRVKLCDFGATTKKGLLVHKVKHTWTSCVPPEQLELIKNERFQCLPVSDSWQFGILLYNILTGNPPWQSADWVKDQSYANFMKYEQRKTTKVPDNFRRFSPRLMRCFRKYLSHDPEDRCKITEVAKYMKDRWVECRISTSKSATLISPTNHDQDSCIYLNQREGRLSGDENKLRFKRMMSTYGLDIPIDQAMVRRRVWDWLSTCDANFDPDVESLHALDLLQ | ||||||
Modified residue | 334 | Phosphoserine; by PKA | ||||
Sequence: S |
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Tissue specificity
Expressed in the mushroom bodies (at protein level).
Developmental stage
Expressed broadly in the third instar larvae and adult flies (at protein levels).
Gene expression databases
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for region, compositional bias, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 15-78 | Disordered | ||||
Sequence: RSFGDGGSTNSRNSNNNSSTCTNHNNQKRCSTPLTPTSTSTGRLEVPGAASVSRRSSIYKKPDK | ||||||
Compositional bias | 17-60 | Polar residues | ||||
Sequence: FGDGGSTNSRNSNNNSSTCTNHNNQKRCSTPLTPTSTSTGRLEV | ||||||
Domain | 101-367 | Protein kinase | ||||
Sequence: YNIEKTLAEGCFAKILLCRHRPTNTLVVLKAVHAELTTIKEFQKEFHYNYELSHHHHILSAYAVAFQTMDYYVFAMEHAPYGDLASNIGPNGLHENACKLISEQLSSALGFMHSKNLVHRDLKIENILVFTPDFTRVKLCDFGATTKKGLLVHKVKHTWTSCVPPEQLELIKNERFQCLPVSDSWQFGILLYNILTGNPPWQSADWVKDQSYANFMKYEQRKTTKVPDNFRRFSPRLMRCFRKYLSHDPEDRCKITEVAKYMKDRWV |
Sequence similarities
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length456
- Mass (Da)52,419
- Last updated2000-05-01 v1
- Checksum272D73C6677C375B
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 17-60 | Polar residues | ||||
Sequence: FGDGGSTNSRNSNNNSSTCTNHNNQKRCSTPLTPTSTSTGRLEV |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AE014134 EMBL· GenBank· DDBJ | AAF52433.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AE014134 EMBL· GenBank· DDBJ | AHN54203.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY071597 EMBL· GenBank· DDBJ | AAL49219.1 EMBL· GenBank· DDBJ | mRNA |