Q9VLT5 · POE_DROME

Function

function

Has a role in growth of the perineurial glial layer of the larval peripheral nerve (PubMed:27552662).
May have a role in male fertility and eye development or function (PubMed:27552662).
Involved in the negative regulation of the Ras/MAPK signaling pathway in the wing by acting with the E2 enzyme Unc6 and the putative E3 ligases Kcmf1 and Ufd4 to mediate the ubiquitination and proteasomal degradation of rl/MAPK (PubMed:27552662).

Features

Showing features for binding site.

153225001,0001,5002,0002,5003,0003,5004,0004,5005,000
TypeIDPosition(s)Description
Binding site4966Zn2+ (UniProtKB | ChEBI)
Binding site4969Zn2+ (UniProtKB | ChEBI)
Binding site5015Zn2+ (UniProtKB | ChEBI)
Binding site5018Zn2+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular ComponentP granule
Molecular Functioncalmodulin binding
Molecular Functionubiquitin protein ligase activity
Molecular Functionzinc ion binding
Biological Processglial cell growth
Biological Processnegative regulation of ERK1 and ERK2 cascade
Biological Processperineurial glial growth
Biological Processpositive regulation of male gonad development
Biological Processpositive regulation of proteasomal ubiquitin-dependent protein catabolic process
Biological Processsperm individualization
Biological Processvisual perception

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Protein purity of essence
  • Alternative names
    • Interaction calmodulin and colossal molecular mass protein
    • Protein Calossin
    • Protein pushover

Gene names

    • Name
      poe
    • Synonyms
      calo
      , push
    • ORF names
      CG14472

Organism names

  • Taxonomic identifier
  • Strain
    • Berkeley
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Brachycera > Muscomorpha > Ephydroidea > Drosophilidae > Drosophila > Sophophora

Accessions

  • Primary accession
    Q9VLT5
  • Secondary accessions
    • O96958
    • Q8MS98
    • Q9XYD1
    • Q9XYD2

Proteomes

Organism-specific databases

Subcellular Location

Phenotypes & Variants

Disruption phenotype

Flies increase the growth of the perineurial glial layer of the larval peripheral nerve and exhibit male sterility due to the inhibition of sperm individualization.

PTM/Processing

Features

Showing features for chain, modified residue.

TypeIDPosition(s)Description
ChainPRO_00002457941-5322Protein purity of essence
Modified residue167Phosphoserine
Modified residue599Phosphothreonine
Modified residue600Phosphoserine
Modified residue1167Phosphoserine
Modified residue1168Phosphoserine
Modified residue1171Phosphoserine
Modified residue1894Phosphoserine
Modified residue3013Phosphothreonine
Modified residue3014Phosphoserine
Modified residue3051Phosphoserine
Modified residue3057Phosphoserine
Modified residue3510Phosphoserine

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Expressed in embryonic central nervous system and adult testes.

Gene expression databases

Interaction

Subunit

May bind calmodulin (PubMed:9813038).
Interacts with Kcmf1 (PubMed:27552662).

Protein-protein interaction databases

Structure

3D structure databases

Family & Domains

Features

Showing features for compositional bias, region, zinc finger, domain.

TypeIDPosition(s)Description
Compositional bias144-165Polar residues
Region144-177Disordered
Compositional bias333-352Polar residues
Region333-358Disordered
Region412-439Disordered
Region589-610Disordered
Region672-694Disordered
Compositional bias675-694Polar residues
Region1139-1184Disordered
Compositional bias1148-1168Polar residues
Compositional bias1169-1184Basic and acidic residues
Region1587-1606Disordered
Zinc finger1794-1863UBR-type
Region2401-2435Disordered
Region2587-2610Disordered
Compositional bias2596-2610Polar residues
Region2993-3075Disordered
Compositional bias2996-3064Polar residues
Compositional bias3484-3501Polar residues
Region3484-3508Disordered
Region4196-4216Disordered
Region4845-5315UBR4 E3 catalytic module
Zinc finger4963-5077HemiRING-type
Domain5080-5315UZI

Sequence similarities

Belongs to the UBR4 family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence & Isoform

Align isoforms (2)
  • Sequence status
    Complete

This entry describes 2 isoforms produced by Alternative splicing.

Q9VLT5-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Length
    5,322
  • Mass (Da)
    590,702
  • Last updated
    2000-05-01 v1
  • Checksum
    3890824E00F2DB50

Q9VLT5-2

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
M9PB68M9PB68_DROMEpoe5322

Sequence caution

The sequence AAM50858.1 differs from that shown. Reason: Erroneous translation Wrong choice of frame.

Features

Showing features for compositional bias, sequence conflict, alternative sequence.

TypeIDPosition(s)Description
Compositional bias144-165Polar residues
Compositional bias333-352Polar residues
Sequence conflict675in Ref. 1; AAD20449/AAD20450
Compositional bias675-694Polar residues
Sequence conflict947in Ref. 1; AAD20449
Compositional bias1148-1168Polar residues
Compositional bias1169-1184Basic and acidic residues
Sequence conflict1405in Ref. 1; AAD20449/AAD20450
Sequence conflict1621in Ref. 1; AAD20449/AAD20450
Compositional bias2596-2610Polar residues
Sequence conflict2965in Ref. 4; CAA76940
Compositional bias2996-3064Polar residues
Sequence conflict3105in Ref. 1; AAD20450
Sequence conflict3159-3164in Ref. 1; AAD20450
Sequence conflict3257in Ref. 4; CAA76940
Compositional bias3484-3501Polar residues
Sequence conflict4011in Ref. 1; AAD20449
Alternative sequenceVSP_0520894119-4120in isoform B
Alternative sequenceVSP_0520904121-5322in isoform B
Sequence conflict4812in Ref. 4; CAA76940

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF096896
EMBL· GenBank· DDBJ
AAD20449.1
EMBL· GenBank· DDBJ
Genomic DNA
AF096897
EMBL· GenBank· DDBJ
AAD20450.1
EMBL· GenBank· DDBJ
mRNA
AE014134
EMBL· GenBank· DDBJ
AAF52598.1
EMBL· GenBank· DDBJ
Genomic DNA
Y17920
EMBL· GenBank· DDBJ
CAA76940.1
EMBL· GenBank· DDBJ
mRNA
AY118998
EMBL· GenBank· DDBJ
AAM50858.1
EMBL· GenBank· DDBJ
mRNA Sequence problems.

Genome annotation databases

Similar Proteins

Disclaimer

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