Q9VL32 · SUR_DROME

Function

function

May function as regulatory subunit of ATP-sensitive potassium channels (KATP) and form KATP channels with a member of the ATP-sensitive inward rectifier potassium channel family (By similarity).
May also have channel activity by itself (in vitro). May protect the heart during hypoxia. May protect against heart failure under conditions of tachycardic stress

Miscellaneous

Drosophila is predominantly active around dawn and dusk, and has large sleep periods during the day and during night. Knockdown of Sur reduces sleep duration during the first half of the night, but has little effect on sleep during the day (PubMed:22105623).

Features

Showing features for binding site.

121712004006008001,0001,2001,4001,6001,8002,000
TypeIDPosition(s)Description
Binding site822-829ATP 1 (UniProtKB | ChEBI)
Binding site1964-1971ATP 2 (UniProtKB | ChEBI)

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentmembrane
Molecular FunctionABC-type transporter activity
Molecular FunctionATP binding
Molecular FunctionATP hydrolysis activity
Molecular FunctionATPase-coupled transmembrane transporter activity
Biological Processresponse to hypoxia
Biological Processtransmembrane transport

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    ATP-binding cassette sub-family C member Sur
  • Alternative names
    • Sulfonylurea receptor (Dsur)

Gene names

    • Name
      Sur
    • ORF names
      CG5772

Organism names

  • Taxonomic identifier
  • Strain
    • Berkeley
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Brachycera > Muscomorpha > Ephydroidea > Drosophilidae > Drosophila > Sophophora

Accessions

  • Primary accession
    Q9VL32
  • Secondary accessions
    • Q9U6Z2

Proteomes

Organism-specific databases

Subcellular Location

Membrane
; Multi-pass membrane protein

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain1-36Extracellular
Transmembrane37-57Helical; Name=1
Topological domain58-71Cytoplasmic
Transmembrane72-92Helical; Name=2
Topological domain93-112Extracellular
Transmembrane113-133Helical; Name=3
Topological domain134-145Cytoplasmic
Transmembrane146-166Helical; Name=4
Topological domain167-182Extracellular
Transmembrane183-203Helical; Name=5
Topological domain204-224Cytoplasmic
Transmembrane225-245Helical; Name=6
Topological domain246-299Extracellular
Transmembrane300-320Helical; Name=7
Topological domain321-447Cytoplasmic
Transmembrane448-468Helical; Name=8
Topological domain469-474Extracellular
Transmembrane475-495Helical; Name=9
Topological domain496-562Cytoplasmic
Transmembrane563-583Helical; Name=10
Topological domain584-600Extracellular
Transmembrane601-621Helical; Name=11
Topological domain622-1409Cytoplasmic
Transmembrane1410-1430Helical; Name=12
Topological domain1431-1468Extracellular
Transmembrane1469-1489Helical; Name=13
Topological domain1490-1558Cytoplasmic
Transmembrane1559-1579Helical; Name=14
Topological domain1580-1655Extracellular
Transmembrane1656-1676Helical; Name=15
Topological domain1677-1718Cytoplasmic
Transmembrane1719-1739Helical; Name=16
Topological domain1740-2171Extracellular

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00004154151-2171ATP-binding cassette sub-family C member Sur

Proteomic databases

Expression

Tissue specificity

Highly expressed in adult heart. Detected at lower levels in head and abdomen.

Developmental stage

Detected in embryonic myocardial cells and in the developing heart tube. Detected in embryonic dorsal vessels and tracheal system.

Gene expression databases

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain, compositional bias, region.

TypeIDPosition(s)Description
Domain344-622ABC transmembrane type-1 1
Compositional bias388-403Polar residues
Region388-434Disordered
Compositional bias419-434Polar residues
Domain785-1014ABC transporter 1
Region1141-1177Disordered
Compositional bias1150-1177Polar residues
Region1193-1265Disordered
Compositional bias1214-1234Polar residues
Compositional bias1241-1258Basic and acidic residues
Domain1421-1715ABC transmembrane type-1 2
Region1766-1844Disordered
Compositional bias1779-1800Basic and acidic residues
Region1866-1902Disordered
Compositional bias1878-1892Polar residues
Domain1930-2165ABC transporter 2

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    2,171
  • Mass (Da)
    242,375
  • Last updated
    2009-03-03 v4
  • Checksum
    5BA7802AD742B6D2
MKQLFNIIHCDHLNGHVRSIYDNLNTDICGIDRVRRVFTFFSIFLLLFGLMFVCSRYKKCHKTLLTFHNGRAAISLLLLALNSFDLARIFLPHQNVRNLNRLFQSSPRDLNYLVVIGSGELWNALFSTLLTLMLMLYHRMVERKKATVFLYASTAVEALTFALLSNELFELVRYEDFLELQTCLVAMSAMCMVSLAMLDGLTVYKECYHDDYLDDYGKIGYKHSMATFYSKSCFWWLTPLLWLGYKEPLELEDLGQMKLEDSARSHYDHFLYIYTEKKKKSNSSPSLWYCYIKNSWQMFALGGILKLAGDLFALIGPLAIQKIVEYIEQLYAQASEPPAKSPGNEVANVLLSTSRILGTEFDEVFGTNIDKGLIYRKSLLLNADGGCDSSDSAGQVQSTSSTSDEKQKNDDSMATPEHVDNPSEPNISHDIGSITNHMTEDTRNIMEFFLIIHYAWAIPFKIAVVIYLLYMNLGISAVIGSIACIVIMTPLQFFIGNAMSKNAEVIAGYTDERLKRIHDTLVGIKVIKLNAWDEVFLKKIQEARRKELKYLNKDATFWTLMAVLTHIATVLITFVTLGVYVWLHRDQEFDLNASRLFSSLALFQQLTVPLLIFPITVPIIIAARVSTRRLERFLKSSEIQKQFEGIRNMARILSKSDASLDMYETQEKSNMTMRTAQAENRLNEKRLAQKSQTPELATNSTPLLQNAEESAEDISPSTVQELGHNKLVQQRRELLRNTPYVAIRPPKMRGSVMERPVEFSVIRARNTDSWRRDSLLLKMPDDIAVSINDGLFTWQPQSQMPVVQLHVPGIIVPKGKLTIVVGKNGSGKTSLLSALLMEMPLLAGNMFWHKTCTISYVSQQPWLLNDTIRENILFGESFRPKRYDFVLEACALKPDIELMPRGDLSIIGERGINISGGQRQRIAIARAIYSSANVVIMDDPLASLDNEVGEHIFQHCIREMLQKSNRTFILVTQQLHRIKEAEYLIAIKDGRVEACGSYADIELMQPRITAEWNAIIAMAKAKNDNPSQNPGEKTAGERWKLLKNVSKLGLQRSISVTMDANVACHADAIDGSGCISVANMQSNVVEEDDQVSVSYPIGNASCGGFNLQRKRSSIYGSRHLMYDVPLPIDECQGDDVIMRPRRRHTLGRRGSRNTNSSHRLSGLSTLTATSESSSISGDVLSRSVLATSCSSYAESSVDGGDLATAAPEPRVQSWQPPQHVTHHQPLSRNASSPPAMEVANPDVKKSEEARRSNTSSESPLDDHVRGSFQQFLRRMSMRRSNKPKNHHHPLSATNSILSISEESPPVVHFPASILATDGNKNETQSEEKPKKCVNIDSKETTINCDDNCYSASDKELRANVTSSPADQEQHNERHVLAEVAGESGRESMPLARLAIDTERKYGKISDDIYLMYIRAAGLPIITIFFITALIWQCLRVYTDIWLQQWSNVHGRVASKGHVVLHPSEQDHEVTYYFRMYAAISCVCIIMALVSTPAGQYAGCNARRNLHDKLLQTILHKTLHFFQVTPLGRIVNRFSNDMAVIDKKIAATGQRLLQFTLLCLSAILINVTITPWILVLTLPICGAYYLIQKFYRCSARELQRIENATNSPVISHLSETIQGVTTIRAFNQQTRFTEILFKRLEANTIAYALLNTSHRWLGVSLDYLGGCIVFVATVTALTAASVSCRRHYEATTSPSASASPSPFETYAVTKSPSELRPSPSLVGLAINYTLLVPIYLNWVVKLLADMEMYAGSVERIAHYAQGQDADADADADADADVDADLDHEPSSNEDVSAEVDRSSQSDAGDKVYPGATTAAGDVDEDGDQQRIGGARGGGGDCGYRQGHENGAEANADKLNAGNVTGDGNHLNFHHPPATAGDKVEQATTKTSVIKDKQLPPQQDDKDKKVVLPNEPARKLERYQSVPISWPQRGDIHFDNVSLRYEGQKQNVISNLTLKIPAGQRIGICGRTGSGKSSLGLSLFGVLQTTRGHIYIDDVDIQRIRPDELRTRLSIIPQDVHLFNATIRENLDPHGYFQDLQLWNCLELAQLKEFVNGHLPLGLDTVICDGGLNLSAGHRQLLCLARAILRGSVCLVLDEATSVLDSSTESALLKAADLAFRGRTIITIAHRLTTILDYDRLIVLDQGRIVEDGNPRELQQLEGSVFRGLLEKGASKW

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
A0A1W5PZ45A0A1W5PZ45_DROMESur2223

Sequence caution

The sequence AAF06736.1 differs from that shown. Reason: Erroneous initiation Extended N-terminus.

Features

Showing features for sequence conflict, compositional bias.

TypeIDPosition(s)Description
Sequence conflict34-35in Ref. 1; AAF06736
Sequence conflict54in Ref. 1; AAF06736
Sequence conflict77in Ref. 1; AAF06736
Sequence conflict85in Ref. 1; AAF06736
Compositional bias388-403Polar residues
Sequence conflict413in Ref. 1; AAF06736
Compositional bias419-434Polar residues
Sequence conflict433in Ref. 1; AAF06736
Sequence conflict444in Ref. 1; AAF06736
Sequence conflict731in Ref. 1; AAF06736
Sequence conflict1022in Ref. 1; AAF06736
Compositional bias1150-1177Polar residues
Compositional bias1214-1234Polar residues
Compositional bias1241-1258Basic and acidic residues
Sequence conflict1603in Ref. 1; AAF06736
Sequence conflict1757in Ref. 1; AAF06736
Sequence conflict1763-1766in Ref. 1; AAF06736
Sequence conflict1772in Ref. 1; AAF06736
Compositional bias1779-1800Basic and acidic residues
Compositional bias1878-1892Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF167431
EMBL· GenBank· DDBJ
AAF06736.1
EMBL· GenBank· DDBJ
mRNA Different initiation
AE014134
EMBL· GenBank· DDBJ
AAF52866.4
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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