Q9VL25 · DHX33_DROME

Function

function

Part of a translational control module, also containing pths/DDX47 and ais/DDX52, which coordinates germline stem cell differentiation with ribosome biogenesis during oogenesis. This module allows for coregulation of ribosomal proteins and non1/GTPBP4, a p53 repressor, preventing p53 stabilization, cell cycle arrest and loss of stem cell differentiation.

Catalytic activity

Features

Showing features for binding site.

169450100150200250300350400450500550600650
TypeIDPosition(s)Description
Binding site91-98ATP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentnucleolus
Molecular FunctionATP binding
Molecular Functiondouble-stranded RNA binding
Molecular Functionhelicase activity
Molecular Functionhydrolase activity
Molecular FunctionRNA helicase activity
Molecular FunctionrRNA binding
Biological Processpositive regulation of transcription by RNA polymerase I
Biological Processribosome biogenesis

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    ATP-dependent RNA helicase DHX33
  • EC number
  • Alternative names
    • DEAH box protein 33 homolog
    • Protein athos

Gene names

    • Name
      ath
    • ORF names
      CG4901

Organism names

  • Taxonomic identifier
  • Strain
    • Berkeley
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Brachycera > Muscomorpha > Ephydroidea > Drosophilidae > Drosophila > Sophophora

Accessions

  • Primary accession
    Q9VL25
  • Secondary accessions
    • Q8MYY2

Proteomes

Organism-specific databases

Subcellular Location

Keywords

Phenotypes & Variants

Disruption phenotype

Conditional RNAi-mediated knock-down in germline cells results in hypotrophy of the nucleolus.

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00004569571-694ATP-dependent RNA helicase DHX33

Proteomic databases

Expression

Gene expression databases

    • FBgn0032194Expressed in embryonic/larval hemocyte (Drosophila) and 44 other cell types or tissues

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for domain, motif.

Type
IDPosition(s)Description
Domain78-246Helicase ATP-binding
Motif188-191DEAH box
Domain270-443Helicase C-terminal

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    694
  • Mass (Da)
    78,319
  • Last updated
    2004-07-05 v2
  • Checksum
    C363A4C0BAD608DE
MDSKYFATSRNDAVGPSPVKFSFKRKYDAMANSPILEKKPHVAQIKQTIAPILLTSKRTSIEQQQKSLPVFNCRHRILKELEANDTVLIMSETGSGKTTQIPQFLLLAGYAKNGMIGITQPRRVAAITVARRVAQELNGTIGDTVGYTVRFEDVTSRATKIRFLTDGVLLRESIKDRLLLKYSVIILDEAHERTVNADLLFGIVKDAQKERRKQKLANLKVVVTSATMDIDHFGNYFNCKGMYLEGRTYPVRVMHTKEEHEDYIHTVLVTLFHIHRTTPKNHDVLIFLTGQEEIESLAQQIRQLAKIDTTGTTDLRVFTLYAQLSQGKQLECFVPTPANVRKVILATNIAETSITIPGIRCVIDCGFVKEKSFNTVDGLDVLKSVRISKAQAWQRAGRAGRDADGTCYRAYTKAEMDSFADATQPEILRTNPTSMVLQLLALDIDCNNFDFLDPPLEDGLRSAYKSLDALGAIKTGDDSYITPLGRQMVQYPLDPKYSKLLLTASSFGCMEEILSLVSVLSSDHVFVSNSEKNEMAALAHAKFQSKHGDHLTLLNVFNGFLKSEKPKMWCHDNYLNLRSLTYARNVRRQLREISEHLHLALNSSDDIEMLKKCILNGFFENIAVLQRDGFYITASGNIRSKIHPSSVLHGKYKPSYILFTEIVQTEQTFLRQVTEISIEWIKEVVPFVKNIPTR

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AE014134
EMBL· GenBank· DDBJ
AAF52873.2
EMBL· GenBank· DDBJ
Genomic DNA
AY113491
EMBL· GenBank· DDBJ
AAM29496.1
EMBL· GenBank· DDBJ
mRNA
AE014134
EMBL· GenBank· DDBJ
API64983.1
EMBL· GenBank· DDBJ
Genomic DNA
AE014134
EMBL· GenBank· DDBJ
API64984.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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