Q9VL25 · DHX33_DROME
- ProteinATP-dependent RNA helicase DHX33
- Geneath
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids694 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
function
Part of a translational control module, also containing pths/DDX47 and ais/DDX52, which coordinates germline stem cell differentiation with ribosome biogenesis during oogenesis. This module allows for coregulation of ribosomal proteins and non1/GTPBP4, a p53 repressor, preventing p53 stabilization, cell cycle arrest and loss of stem cell differentiation.
Catalytic activity
- ATP + H2O = ADP + phosphate + H+
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 91-98 | ATP (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | nucleolus | |
Molecular Function | ATP binding | |
Molecular Function | double-stranded RNA binding | |
Molecular Function | helicase activity | |
Molecular Function | hydrolase activity | |
Molecular Function | RNA helicase activity | |
Molecular Function | rRNA binding | |
Biological Process | positive regulation of transcription by RNA polymerase I | |
Biological Process | ribosome biogenesis |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameATP-dependent RNA helicase DHX33
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Brachycera > Muscomorpha > Ephydroidea > Drosophilidae > Drosophila > Sophophora
Accessions
- Primary accessionQ9VL25
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
Phenotypes & Variants
Disruption phenotype
Conditional RNAi-mediated knock-down in germline cells results in hypotrophy of the nucleolus.
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000456957 | 1-694 | ATP-dependent RNA helicase DHX33 | ||
Proteomic databases
Expression
Gene expression databases
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain, motif.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 78-246 | Helicase ATP-binding | |||
Motif | 188-191 | DEAH box | |||
Domain | 270-443 | Helicase C-terminal | |||
Sequence similarities
Belongs to the DEAD box helicase family. DEAH subfamily.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length694
- Mass (Da)78,319
- Last updated2004-07-05 v2
- ChecksumC363A4C0BAD608DE
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AE014134 EMBL· GenBank· DDBJ | AAF52873.2 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY113491 EMBL· GenBank· DDBJ | AAM29496.1 EMBL· GenBank· DDBJ | mRNA | ||
AE014134 EMBL· GenBank· DDBJ | API64983.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AE014134 EMBL· GenBank· DDBJ | API64984.1 EMBL· GenBank· DDBJ | Genomic DNA |