Q9VKJ0 · HGD_DROME
- ProteinHomogentisate 1,2-dioxygenase
- GeneHgo
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids439 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score3/5
Function
Catalytic activity
- homogentisate + O2 = 4-maleylacetoacetate + H+
Cofactor
Pathway
Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 4/6.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 335 | Fe cation (UniProtKB | ChEBI) | |||
Binding site | 341 | Fe cation (UniProtKB | ChEBI) | |||
Binding site | 371 | Fe cation (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | homogentisate 1,2-dioxygenase activity | |
Molecular Function | metal ion binding | |
Biological Process | L-phenylalanine catabolic process | |
Biological Process | tyrosine catabolic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameHomogentisate 1,2-dioxygenase
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Brachycera > Muscomorpha > Ephydroidea > Drosophilidae > Drosophila > Sophophora
Accessions
- Primary accessionQ9VKJ0
- Secondary accessions
Proteomes
Organism-specific databases
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000220242 | 1-439 | Homogentisate 1,2-dioxygenase | ||
Proteomic databases
Expression
Gene expression databases
Structure
Sequence
- Sequence statusComplete
- Length439
- Mass (Da)49,398
- Last updated2003-07-25 v3
- MD5 ChecksumC794BF621B9C0F2B4A9980828F7B2C9A
Features
Showing features for sequence conflict.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Sequence conflict | 96-106 | in Ref. 1; AAF36489 | |||
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AF131124 EMBL· GenBank· DDBJ | AAF36489.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AE014134 EMBL· GenBank· DDBJ | AAF53078.2 EMBL· GenBank· DDBJ | Genomic DNA | ||
BT003496 EMBL· GenBank· DDBJ | AAO39500.1 EMBL· GenBank· DDBJ | mRNA |