Q9VJQ5 · NC2B_DROME

Function

function

Bifunctional basic transcription factor. Activates transcription of DPE (Downstream Promoter Element) containing promoters while repressing transcription of promoters which contain TATA elements (PubMed:11062130).
Together with Chrac-14, promotes nucleosome sliding of ATP-dependent nucelosome remodeling complexes (PubMed:18327268).

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular ComponentATAC complex
Cellular Componentnegative cofactor 2 complex
Cellular Componentnucleus
Molecular Functioncore promoter sequence-specific DNA binding
Molecular FunctionDNA-binding transcription factor binding
Molecular Functionprotein heterodimerization activity
Molecular FunctionRNA polymerase II general transcription initiation factor activity
Molecular FunctionTBP-class protein binding
Biological Processchromatin remodeling
Biological Processnegative regulation of DNA-templated transcription
Biological Processnegative regulation of transcription by RNA polymerase II
Biological Processpositive regulation of DNA-templated transcription
Biological Processpositive regulation of transcription by RNA polymerase II
Biological ProcessRNA polymerase II preinitiation complex assembly

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Protein Dr1
  • Alternative names
    • Down-regulator of transcription 1
    • Negative cofactor 2-beta (NC2-beta)
    • dNC2

Gene names

    • Name
      NC2beta
    • Synonyms
      Dr1
    • ORF names
      CG4185

Organism names

  • Taxonomic identifier
  • Strains
    • Berkeley
    • Ral1
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Brachycera > Muscomorpha > Ephydroidea > Drosophilidae > Drosophila > Sophophora

Accessions

  • Primary accession
    Q9VJQ5
  • Secondary accessions
    • Q2XYD4
    • Q9NKA2

Proteomes

Organism-specific databases

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00000967521-183Protein Dr1

Proteomic databases

Expression

Gene expression databases

    • FBgn0028926Expressed in oviduct (Drosophila) and 33 other cell types or tissues

Interaction

Subunit

Component of the Ada2a-containing (ATAC) complex composed of at least Ada2a, Atac1, Hcf, Ada3, Gcn5, Mocs2B, Charac-14, Atac3, Atac2, NC2beta and wds (PubMed:18327268).
Homodimer (PubMed:18327268).
Interacts with NC2-alpha/Drap1 to form the dNC2 complex (PubMed:11062130).

Binary interactions

TypeEntry 1Entry 2Number of experimentsIntact
BINARY Q9VJQ5NC2alpha Q9GSP14EBI-176193, EBI-22062696
BINARY Q9VJQ5Taf11 P499063EBI-176193, EBI-187533
View interactors in UniProtKB
View CPX-2742 in Complex Portal

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for domain, region.

TypeIDPosition(s)Description
Domain19-82Histone-fold
Region92-183Repression of TATA-containing promoters
Region155-183Disordered

Sequence similarities

Belongs to the NC2 beta/DR1 family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    183
  • Mass (Da)
    20,914
  • Last updated
    2000-05-01 v1
  • Checksum
    BE7B25679CE02F7C
MSNPQEELLPPSAEDDELTLPRASINKIIKELVPTVRVANESRELILNCCSEFIHLISSEANEVCNMRNKKTINAEHVLEALERLGFHDYKQEAEAVLHDCKEVAAKRRRQSTRLENLGIPEEELLRQQQELFAKAREEQAREEQQQWMSMQAAAMVQRPPLADGSVASKPSEDDDDDDDDDY

Sequence caution

The sequence AAL28265.2 differs from that shown. Reason: Erroneous translation Wrong choice of frame.

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF302257
EMBL· GenBank· DDBJ
AAG15388.1
EMBL· GenBank· DDBJ
mRNA
AE014134
EMBL· GenBank· DDBJ
AAF53428.1
EMBL· GenBank· DDBJ
Genomic DNA
AY060717
EMBL· GenBank· DDBJ
AAL28265.2
EMBL· GenBank· DDBJ
mRNA Sequence problems.
DQ138728
EMBL· GenBank· DDBJ
ABA86334.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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