Q9VJ14 · Q9VJ14_DROME
- ProteinRING-type E3 ubiquitin transferase
- Genemib2
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids1049 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
Catalytic activity
Pathway
Protein modification; protein ubiquitination.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | M band | |
Cellular Component | Z disc | |
Molecular Function | myosin II heavy chain binding | |
Molecular Function | myosin II light chain binding | |
Molecular Function | ubiquitin protein ligase activity | |
Molecular Function | zinc ion binding | |
Biological Process | muscle cell cellular homeostasis | |
Biological Process | myoblast fusion | |
Biological Process | Notch signaling pathway | |
Biological Process | protein polyubiquitination |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameRING-type E3 ubiquitin transferase
- EC number
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Brachycera > Muscomorpha > Ephydroidea > Drosophilidae > Drosophila > Sophophora
Accessions
- Primary accessionQ9VJ14
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Keywords
- Cellular component
PTM/Processing
Proteomic databases
Expression
Gene expression databases
Structure
Family & Domains
Features
Showing features for domain, repeat, region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 1-76 | MIB/HERC2 | ||||
Sequence: MRASIPPGIRVVRGPNWIWSNQDDGEGHVGTVCEIGRCGSTHSPENTVVVNWDSGHRTNYRVGYQNQYDLIIVDNA | ||||||
Domain | 82-134 | ZZ-type | ||||
Sequence: HSNVVCDGCSKAGIAGIVFKCAQCPNYHLCAYCYAEDLHDIEHPFIRYTTPNS | ||||||
Domain | 145-223 | MIB/HERC2 | ||||
Sequence: AKRIQLRGIFVGSKVVRGPDWEWNEQDGGEGRTGRVMEIRGWDNESCRSVANVAWVTGSTNVYRLGHKGNVDLKYITAT | ||||||
Repeat | 463-495 | ANK | ||||
Sequence: GGKACIQVASHQGYVDLVSYLISKGANVNAVDK | ||||||
Repeat | 496-528 | ANK | ||||
Sequence: EGDSALHYAAFGNQPATMRVLLQHGAEVNFLNS | ||||||
Repeat | 529-561 | ANK | ||||
Sequence: SHCSALHICAHKKTPHCVRELLQHNANVNIQDS | ||||||
Repeat | 630-654 | ANK | ||||
Sequence: DGFAALHLAALNGHAQVVETLVTEG | ||||||
Repeat | 664-696 | ANK | ||||
Sequence: RQQTPFLLAVSQGHAGVIERLVRLSCDVNAKDE | ||||||
Region | 801-909 | Disordered | ||||
Sequence: SAGSADGEESSASAGAESNGAGPGSVAAPPPPQRQTFELMPKPNDIPAIGVGASPSTPSASPGVKKLNSDATPQNVSPQVAPRKKAPKPPVTTSSSSTALEAGAAGPST | ||||||
Compositional bias | 854-879 | Polar residues | ||||
Sequence: SPSTPSASPGVKKLNSDATPQNVSPQ | ||||||
Compositional bias | 889-904 | Polar residues | ||||
Sequence: PPVTTSSSSTALEAGA | ||||||
Domain | 1006-1039 | RING-type | ||||
Sequence: CGICMERKRDVAFLCGHGACSHCAETLRTCHMCR |
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,049
- Mass (Da)114,868
- Last updated2000-05-01 v1
- Checksum887E0AC662FB4C67
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 854-879 | Polar residues | ||||
Sequence: SPSTPSASPGVKKLNSDATPQNVSPQ | ||||||
Compositional bias | 889-904 | Polar residues | ||||
Sequence: PPVTTSSSSTALEAGA |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AE014134 EMBL· GenBank· DDBJ | AAF53743.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BT016111 EMBL· GenBank· DDBJ | AAV36996.1 EMBL· GenBank· DDBJ | mRNA | ||
AE014134 EMBL· GenBank· DDBJ | AGB93089.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AE014134 EMBL· GenBank· DDBJ | AGB93090.1 EMBL· GenBank· DDBJ | Genomic DNA |