Q9VIV2 · SWM_DROME

Function

function

Negatively regulates Hedgehog (hh) protein signal in wing development (PubMed:18245841).
Regulates neural-specific glycosylation by binding to FucTA mRNA and facilitating its nuclear export in neural cells (PubMed:21203496).

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentnucleus
Molecular Functionmetal ion binding
Molecular FunctionmRNA binding
Molecular FunctionRNA binding
Biological ProcessmRNA transport
Biological Processpositive regulation of gene expression
Biological Processpositive regulation of RNA export from nucleus

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Zinc finger protein swm
  • Alternative names
    • Protein second mitotic wave missing

Gene names

    • Name
      swm
    • ORF names
      CG10084

Organism names

  • Taxonomic identifier
  • Strain
    • Berkeley
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Brachycera > Muscomorpha > Ephydroidea > Drosophilidae > Drosophila > Sophophora

Accessions

  • Primary accession
    Q9VIV2
  • Secondary accessions
    • B1NLF3
    • B1NLF4

Proteomes

Organism-specific databases

Subcellular Location

Keywords

Phenotypes & Variants

Disruption phenotype

Recessive lethal (PubMed:18245841).
Heteroallelic larvae are severely developmentally delayed and most have wing disks smaller than wild-type (PubMed:18245841).
Heteroallelic adult flies show defects in wing hair orientation (PubMed:18245841).
Defective alpha-1,3-fucosylation (PubMed:21203496).
RNAi-mediated knockdown in the eye results in reduced FucTA protein levels (PubMed:21203496).

Features

Showing features for mutagenesis.

TypeIDPosition(s)Description
Mutagenesis921In swmF15; recessive lethal and induces reduced fucosylation levels.

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00004386591-1062Zinc finger protein swm

Proteomic databases

Expression

Developmental stage

Expressed in precellular embryo along the ventral midline and, in germ-band retraction embryos, in segmental stripes. Expressed in third instar larvae in imaginal disks, salivary gland, optic lobe, fat body, wreath cells and gastric caecae of the gut.

Gene expression databases

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for domain, region, compositional bias, zinc finger.

TypeIDPosition(s)Description
Domain7-75PWI
Region119-145Disordered
Region171-340Disordered
Compositional bias246-276Basic and acidic residues
Compositional bias284-327Basic and acidic residues
Zinc finger363-391C3H1-type
Region416-463Disordered
Compositional bias427-441Pro residues
Compositional bias442-462Polar residues
Domain561-635RRM
Region666-704Disordered
Compositional bias677-704Polar residues
Region716-741Disordered
Region822-847Disordered
Compositional bias823-841Polar residues
Region886-920Disordered
Region1004-1062Disordered
Compositional bias1020-1037Polar residues

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,062
  • Mass (Da)
    115,717
  • Last updated
    2000-05-01 v1
  • Checksum
    8A80CF12C504380D
MILENSDKLKDWLSVVLEPLCDADSSALARYVIALLKKDKSDKDLKRIMIEQLDVFLSEETTRFVERLFDAIASEEYLTVPAAPLITASSASTAELTVDQELALVIDGPQDDIEAVLVADSPPPPPKDNVIKPDSNQVKLEQASQDAREAEALAFISQEAGIAMHVPTDAKPAFDHKTKDSHNQQSASNYQHHHVRSASPPGRSSGVSGSGGGGPGGAGLAAGYADKENQPRDSRRRRASLRSRSRSRSRSNERAFRRSRSRDRRVNEREKTQRQFRNKSPPGSQTDNRHHGRRNFDRRRIGGNADDRPRFGNNKSRRSHSRSMSPERNARRNQNSPDRVQTAQANLIPAPVAPPAPVEHPASHPRQRCRDFDEKGYCVRGETCPWDHGVNPVVFEGINNTSLMMSMREYNPDAPEIWARSGGPPPGAGQGPVPPPTQPGQTTINPFSGNVRPTTLMSGSGPSPMGVPNPADYARNPGAPPQAAMMPFPFNPTAVTTPLQRQLIPIPVVDGAPTGGVAEVGKRRFELEDTVAIADVPTKRKVPINSRLGPRVNPNMQQHNSSLELRKVPRGLNTIAHLNNHFAKFGKIVNIQVSYEGDPEAAIVTFSTHAEANVAYRSTEAVLNNRFIKVFWHNDSSGADVGQMNQMGGGGGGGGRKNASQYHLHNVPAVPTPNADGAKISNANPLTEAGAGNIGTPATEQANTAAPASMRLKLNTTTAGGSAGGAAGAGAPGSGRPLNPAANAASIRKKQEEQQKAVHQLANGLRKRKQELLQSYMKQMKTALELVERMDQQDPQRAPTLQTIKVLQMTIDKLRKEIKADQDQLQAQMQQQQQQQQPPVKKTKEQQKKELLDMELELIAQQQEGNDTTAIQKRLEELQRNLGVGSAANNKSTHYAPASGAPGGGAGRKRPNLPEGPTRVDRRPKAIVVTGFAAEEADFVLGHFKNFGEISKHDVDREIPQLILSYATRLNAEQAVLRGKMYKDKRLQISWAPVVTPAPAPMAAPVEKSAAPGDMSVSLENPKQLIQSVSESESLLGSDTLPELRLEDEEEDEESEDRSWRR

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
M9PDF2M9PDF2_DROMEswm1063

Features

Showing features for compositional bias, sequence conflict.

TypeIDPosition(s)Description
Compositional bias246-276Basic and acidic residues
Compositional bias284-327Basic and acidic residues
Sequence conflict402in Ref. 1; ABV58369/ABV58370
Compositional bias427-441Pro residues
Compositional bias442-462Polar residues
Compositional bias677-704Polar residues
Compositional bias823-841Polar residues
Compositional bias1020-1037Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
EF601876
EMBL· GenBank· DDBJ
ABV58368.1
EMBL· GenBank· DDBJ
mRNA
EF601877
EMBL· GenBank· DDBJ
ABV58369.1
EMBL· GenBank· DDBJ
Genomic DNA
EF601878
EMBL· GenBank· DDBJ
ABV58370.1
EMBL· GenBank· DDBJ
Genomic DNA
AE014134
EMBL· GenBank· DDBJ
AAF53812.1
EMBL· GenBank· DDBJ
Genomic DNA
AE014134
EMBL· GenBank· DDBJ
AAN11045.1
EMBL· GenBank· DDBJ
Genomic DNA
AY095056
EMBL· GenBank· DDBJ
AAM11384.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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