Q9VIV2 · SWM_DROME
- ProteinZinc finger protein swm
- Geneswm
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids1062 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
function
Negatively regulates Hedgehog (hh) protein signal in wing development (PubMed:18245841).
Regulates neural-specific glycosylation by binding to FucTA mRNA and facilitating its nuclear export in neural cells (PubMed:21203496).
Regulates neural-specific glycosylation by binding to FucTA mRNA and facilitating its nuclear export in neural cells (PubMed:21203496).
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | nucleus | |
Molecular Function | metal ion binding | |
Molecular Function | mRNA binding | |
Molecular Function | RNA binding | |
Biological Process | mRNA transport | |
Biological Process | positive regulation of gene expression | |
Biological Process | positive regulation of RNA export from nucleus |
Keywords
- Molecular function
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameZinc finger protein swm
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Brachycera > Muscomorpha > Ephydroidea > Drosophilidae > Drosophila > Sophophora
Accessions
- Primary accessionQ9VIV2
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
Phenotypes & Variants
Disruption phenotype
Recessive lethal (PubMed:18245841).
Heteroallelic larvae are severely developmentally delayed and most have wing disks smaller than wild-type (PubMed:18245841).
Heteroallelic adult flies show defects in wing hair orientation (PubMed:18245841).
Defective alpha-1,3-fucosylation (PubMed:21203496).
RNAi-mediated knockdown in the eye results in reduced FucTA protein levels (PubMed:21203496).
Heteroallelic larvae are severely developmentally delayed and most have wing disks smaller than wild-type (PubMed:18245841).
Heteroallelic adult flies show defects in wing hair orientation (PubMed:18245841).
Defective alpha-1,3-fucosylation (PubMed:21203496).
RNAi-mediated knockdown in the eye results in reduced FucTA protein levels (PubMed:21203496).
Features
Showing features for mutagenesis.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Mutagenesis | 921 | In swmF15; recessive lethal and induces reduced fucosylation levels. | ||||
Sequence: D → N |
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000438659 | 1-1062 | Zinc finger protein swm | |||
Sequence: MILENSDKLKDWLSVVLEPLCDADSSALARYVIALLKKDKSDKDLKRIMIEQLDVFLSEETTRFVERLFDAIASEEYLTVPAAPLITASSASTAELTVDQELALVIDGPQDDIEAVLVADSPPPPPKDNVIKPDSNQVKLEQASQDAREAEALAFISQEAGIAMHVPTDAKPAFDHKTKDSHNQQSASNYQHHHVRSASPPGRSSGVSGSGGGGPGGAGLAAGYADKENQPRDSRRRRASLRSRSRSRSRSNERAFRRSRSRDRRVNEREKTQRQFRNKSPPGSQTDNRHHGRRNFDRRRIGGNADDRPRFGNNKSRRSHSRSMSPERNARRNQNSPDRVQTAQANLIPAPVAPPAPVEHPASHPRQRCRDFDEKGYCVRGETCPWDHGVNPVVFEGINNTSLMMSMREYNPDAPEIWARSGGPPPGAGQGPVPPPTQPGQTTINPFSGNVRPTTLMSGSGPSPMGVPNPADYARNPGAPPQAAMMPFPFNPTAVTTPLQRQLIPIPVVDGAPTGGVAEVGKRRFELEDTVAIADVPTKRKVPINSRLGPRVNPNMQQHNSSLELRKVPRGLNTIAHLNNHFAKFGKIVNIQVSYEGDPEAAIVTFSTHAEANVAYRSTEAVLNNRFIKVFWHNDSSGADVGQMNQMGGGGGGGGRKNASQYHLHNVPAVPTPNADGAKISNANPLTEAGAGNIGTPATEQANTAAPASMRLKLNTTTAGGSAGGAAGAGAPGSGRPLNPAANAASIRKKQEEQQKAVHQLANGLRKRKQELLQSYMKQMKTALELVERMDQQDPQRAPTLQTIKVLQMTIDKLRKEIKADQDQLQAQMQQQQQQQQPPVKKTKEQQKKELLDMELELIAQQQEGNDTTAIQKRLEELQRNLGVGSAANNKSTHYAPASGAPGGGAGRKRPNLPEGPTRVDRRPKAIVVTGFAAEEADFVLGHFKNFGEISKHDVDREIPQLILSYATRLNAEQAVLRGKMYKDKRLQISWAPVVTPAPAPMAAPVEKSAAPGDMSVSLENPKQLIQSVSESESLLGSDTLPELRLEDEEEDEESEDRSWRR |
Proteomic databases
Expression
Developmental stage
Expressed in precellular embryo along the ventral midline and, in germ-band retraction embryos, in segmental stripes. Expressed in third instar larvae in imaginal disks, salivary gland, optic lobe, fat body, wreath cells and gastric caecae of the gut.
Gene expression databases
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias, zinc finger.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 7-75 | PWI | ||||
Sequence: DKLKDWLSVVLEPLCDADSSALARYVIALLKKDKSDKDLKRIMIEQLDVFLSEETTRFVERLFDAIASE | ||||||
Region | 119-145 | Disordered | ||||
Sequence: ADSPPPPPKDNVIKPDSNQVKLEQASQ | ||||||
Region | 171-340 | Disordered | ||||
Sequence: KPAFDHKTKDSHNQQSASNYQHHHVRSASPPGRSSGVSGSGGGGPGGAGLAAGYADKENQPRDSRRRRASLRSRSRSRSRSNERAFRRSRSRDRRVNEREKTQRQFRNKSPPGSQTDNRHHGRRNFDRRRIGGNADDRPRFGNNKSRRSHSRSMSPERNARRNQNSPDRV | ||||||
Compositional bias | 246-276 | Basic and acidic residues | ||||
Sequence: RSRSRSNERAFRRSRSRDRRVNEREKTQRQF | ||||||
Compositional bias | 284-327 | Basic and acidic residues | ||||
Sequence: SQTDNRHHGRRNFDRRRIGGNADDRPRFGNNKSRRSHSRSMSPE | ||||||
Zinc finger | 363-391 | C3H1-type | ||||
Sequence: SHPRQRCRDFDEKGYCVRGETCPWDHGVN | ||||||
Region | 416-463 | Disordered | ||||
Sequence: EIWARSGGPPPGAGQGPVPPPTQPGQTTINPFSGNVRPTTLMSGSGPS | ||||||
Compositional bias | 427-441 | Pro residues | ||||
Sequence: GAGQGPVPPPTQPGQ | ||||||
Compositional bias | 442-462 | Polar residues | ||||
Sequence: TTINPFSGNVRPTTLMSGSGP | ||||||
Domain | 561-635 | RRM | ||||
Sequence: SSLELRKVPRGLNTIAHLNNHFAKFGKIVNIQVSYEGDPEAAIVTFSTHAEANVAYRSTEAVLNNRFIKVFWHND | ||||||
Region | 666-704 | Disordered | ||||
Sequence: NVPAVPTPNADGAKISNANPLTEAGAGNIGTPATEQANT | ||||||
Compositional bias | 677-704 | Polar residues | ||||
Sequence: GAKISNANPLTEAGAGNIGTPATEQANT | ||||||
Region | 716-741 | Disordered | ||||
Sequence: TTTAGGSAGGAAGAGAPGSGRPLNPA | ||||||
Region | 822-847 | Disordered | ||||
Sequence: QDQLQAQMQQQQQQQQPPVKKTKEQQ | ||||||
Compositional bias | 823-841 | Polar residues | ||||
Sequence: DQLQAQMQQQQQQQQPPVK | ||||||
Region | 886-920 | Disordered | ||||
Sequence: SAANNKSTHYAPASGAPGGGAGRKRPNLPEGPTRV | ||||||
Region | 1004-1062 | Disordered | ||||
Sequence: APVEKSAAPGDMSVSLENPKQLIQSVSESESLLGSDTLPELRLEDEEEDEESEDRSWRR | ||||||
Compositional bias | 1020-1037 | Polar residues | ||||
Sequence: ENPKQLIQSVSESESLLG |
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,062
- Mass (Da)115,717
- Last updated2000-05-01 v1
- Checksum8A80CF12C504380D
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
M9PDF2 | M9PDF2_DROME | swm | 1063 |
Features
Showing features for compositional bias, sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 246-276 | Basic and acidic residues | ||||
Sequence: RSRSRSNERAFRRSRSRDRRVNEREKTQRQF | ||||||
Compositional bias | 284-327 | Basic and acidic residues | ||||
Sequence: SQTDNRHHGRRNFDRRRIGGNADDRPRFGNNKSRRSHSRSMSPE | ||||||
Sequence conflict | 402 | in Ref. 1; ABV58369/ABV58370 | ||||
Sequence: S → A | ||||||
Compositional bias | 427-441 | Pro residues | ||||
Sequence: GAGQGPVPPPTQPGQ | ||||||
Compositional bias | 442-462 | Polar residues | ||||
Sequence: TTINPFSGNVRPTTLMSGSGP | ||||||
Compositional bias | 677-704 | Polar residues | ||||
Sequence: GAKISNANPLTEAGAGNIGTPATEQANT | ||||||
Compositional bias | 823-841 | Polar residues | ||||
Sequence: DQLQAQMQQQQQQQQPPVK | ||||||
Compositional bias | 1020-1037 | Polar residues | ||||
Sequence: ENPKQLIQSVSESESLLG |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
EF601876 EMBL· GenBank· DDBJ | ABV58368.1 EMBL· GenBank· DDBJ | mRNA | ||
EF601877 EMBL· GenBank· DDBJ | ABV58369.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
EF601878 EMBL· GenBank· DDBJ | ABV58370.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AE014134 EMBL· GenBank· DDBJ | AAF53812.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AE014134 EMBL· GenBank· DDBJ | AAN11045.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY095056 EMBL· GenBank· DDBJ | AAM11384.1 EMBL· GenBank· DDBJ | mRNA |