Q9VIS4 · Q9VIS4_DROME

Function

function

Catalyzes the synthesis of dihydrouridine, a modified base, in various RNAs, such as tRNAs, mRNAs and some long non-coding RNAs (lncRNAs). Mainly modifies the uridine in position 47 (U47) in the D-loop of most cytoplasmic tRNAs. Also able to mediate the formation of dihydrouridine in some mRNAs, thereby regulating their translation.

Catalytic activity

Cofactor

FMN (UniProtKB | Rhea| CHEBI:58210 )

GO annotations

AspectTerm
Molecular Functionflavin adenine dinucleotide binding
Molecular Functionmetal ion binding
Molecular FunctionmRNA dihydrouridine synthase activity
Molecular FunctiontRNA dihydrouridine synthase activity
Molecular FunctiontRNA-dihydrouridine47 synthase activity

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    tRNA-dihydrouridine(47) synthase [NAD(P)(+)]
  • EC number
  • Alternative names
    • tRNA-dihydrouridine synthase 3

Gene names

    • Name
      Dus3
    • Synonyms
      Dmel\CG10463
    • ORF names
      CG10463
      , Dmel_CG10463

Organism names

  • Taxonomic identifier
  • Strain
    • Berkeley
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Brachycera > Muscomorpha > Ephydroidea > Drosophilidae > Drosophila > Sophophora

Accessions

  • Primary accession
    Q9VIS4

Proteomes

Organism-specific databases

PTM/Processing

Proteomic databases

Expression

Gene expression databases

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for region, compositional bias, domain, zinc finger.

Type
IDPosition(s)Description
Region18-63Disordered
Compositional bias29-63Basic and acidic residues
Domain112-137C3H1-type
Zinc finger112-137C3H1-type
Region137-158Disordered
Compositional bias190-227Basic and acidic residues
Region190-242Disordered

Sequence similarities

Belongs to the dus family. Dus3 subfamily.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    604
  • Mass (Da)
    68,025
  • Last updated
    2000-05-01 v1
  • Checksum
    465190A1AA954D85
MDSGICYIKPEYLVTEADGGSAAANTENSDTNKRKREDGGEVEAGEKKKWDKKERKRGQNKNRPVFKDERYSHLCHSLIDGTGGEPCSLANCRYVHDLDAYLAAKGEDLGPECYVYTTKGYCARGVSCRFAKAHTDEQGRNLKREDYDENAPPTTCNGVSSELQVRLRKHEYDFSRSKELIKMAEKLRDARKLKEQQEKEKNPSEETGEKQPSETTEILDAEKQTDTKSKPTATGCAIDDSAIGRDADHKPAVDFREKLVLSPLTTLGNLPFRRICKEFGADITCGEMACAQPLLKGMGQEWALTKRHQSEDVFGVQLCGNNPNMLNQAAQVIHETAQVDFIDLNIGCPIDLIYQQGGGSALMRRTNILELTVRSCAALSDRLPFTVKMRTGIYADKSVAHELLPLVEEWGASAVTLHGRSREQRYTKHANWAYIEECAAKAKCMPVIGNGDILSYEDYMERRTLAPHVCSVMIGRGALIKPWIFQEIKEKQAWSPSSGQRYEMLQKFCNYGLEHWGSDTKGVETTRRFLLEWQSFLYRYIPEALQTAPPQKINARPQKYRGRDEMETLMSSGNAADWVKLSESLLGRVPEGFTFVPKHKANAF

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias29-63Basic and acidic residues
Compositional bias190-227Basic and acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AE014134
EMBL· GenBank· DDBJ
AAF53841.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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