Q9VIS4 · Q9VIS4_DROME
- ProteintRNA-dihydrouridine(47) synthase [NAD(P)(+)]
- GeneDus3
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids604 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score3/5
Function
function
Catalyzes the synthesis of dihydrouridine, a modified base, in various RNAs, such as tRNAs, mRNAs and some long non-coding RNAs (lncRNAs). Mainly modifies the uridine in position 47 (U47) in the D-loop of most cytoplasmic tRNAs. Also able to mediate the formation of dihydrouridine in some mRNAs, thereby regulating their translation.
Catalytic activity
- 5,6-dihydrouridine47 in tRNA + NAD+ = uridine47 in tRNA + NADH + H+This reaction proceeds in the backward direction.
- a 5,6-dihydrouridine in mRNA + NAD+ = a uridine in mRNA + NADH + H+This reaction proceeds in the backward direction.
- a 5,6-dihydrouridine in mRNA + NADP+ = a uridine in mRNA + NADPH + H+This reaction proceeds in the backward direction.
Cofactor
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | flavin adenine dinucleotide binding | |
Molecular Function | metal ion binding | |
Molecular Function | mRNA dihydrouridine synthase activity | |
Molecular Function | tRNA dihydrouridine synthase activity | |
Molecular Function | tRNA-dihydrouridine47 synthase activity |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nametRNA-dihydrouridine(47) synthase [NAD(P)(+)]
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Brachycera > Muscomorpha > Ephydroidea > Drosophilidae > Drosophila > Sophophora
Accessions
- Primary accessionQ9VIS4
Proteomes
Organism-specific databases
PTM/Processing
Proteomic databases
Expression
Gene expression databases
Structure
Family & Domains
Features
Showing features for region, compositional bias, domain, zinc finger.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Region | 18-63 | Disordered | |||
Compositional bias | 29-63 | Basic and acidic residues | |||
Domain | 112-137 | C3H1-type | |||
Zinc finger | 112-137 | C3H1-type | |||
Region | 137-158 | Disordered | |||
Compositional bias | 190-227 | Basic and acidic residues | |||
Region | 190-242 | Disordered | |||
Sequence similarities
Belongs to the dus family. Dus3 subfamily.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length604
- Mass (Da)68,025
- Last updated2000-05-01 v1
- Checksum465190A1AA954D85
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 29-63 | Basic and acidic residues | |||
Compositional bias | 190-227 | Basic and acidic residues | |||
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AE014134 EMBL· GenBank· DDBJ | AAF53841.1 EMBL· GenBank· DDBJ | Genomic DNA |