Q9VIF3 · Q9VIF3_DROME
- ProteinUbiquinone biosynthesis O-methyltransferase, mitochondrial
- GeneCoq3
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids310 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway.
Catalytic activity
- a 3,4-dihydroxy-5-all-trans-polyprenylbenzoate + S-adenosyl-L-methionine = a 3-methoxy,4-hydroxy-5-all-trans-polyprenylbenzoate + S-adenosyl-L-homocysteine + H+
a 3,4-dihydroxy-5-all-trans-polyprenylbenzoate RHEA-COMP:10930 + CHEBI:59789 = a 3-methoxy,4-hydroxy-5-all-trans-polyprenylbenzoate RHEA-COMP:10931 + CHEBI:57856 + CHEBI:15378
Pathway
Cofactor biosynthesis; ubiquinone biosynthesis.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 69 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | ||||
Sequence: R | ||||||
Binding site | 103 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | ||||
Sequence: G | ||||||
Binding site | 124 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 172 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | ||||
Sequence: S |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | extrinsic component of mitochondrial inner membrane | |
Cellular Component | mitochondrial inner membrane | |
Cellular Component | mitochondrion | |
Cellular Component | ubiquinone biosynthesis complex | |
Molecular Function | 3,4-dihydroxy-5-polyprenylbenzoic acid O-methyltransferase activity | |
Molecular Function | 3-demethylubiquinol-n 3-O-methyltransferase activity | |
Biological Process | methylation | |
Biological Process | ubiquinone biosynthetic process | |
Biological Process | wound healing |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameUbiquinone biosynthesis O-methyltransferase, mitochondrial
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Brachycera > Muscomorpha > Ephydroidea > Drosophilidae > Drosophila > Sophophora
Accessions
- Primary accessionQ9VIF3
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Mitochondrion inner membrane ; Peripheral membrane protein
Keywords
- Cellular component
PTM/Processing
Proteomic databases
Expression
Gene expression databases
Interaction
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 100-200 | Methyltransferase type 11 | ||||
Sequence: LEVGCGGGLLTEHLARLGAQVAGIDLGEKLIEAAREHLKCSSPELASNVVYKIEPVDQHAKANCECYDAVIVSEVLEHVKDKVSLLEASVRSLKPGGSIFI |
Sequence similarities
Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length310
- Mass (Da)34,379
- Last updated2002-10-01 v3
- ChecksumCCEDD53C756D27FD
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
E1JHN2 | E1JHN2_DROME | Coq3 | 289 |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AE014134 EMBL· GenBank· DDBJ | AAF53967.3 EMBL· GenBank· DDBJ | Genomic DNA |