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Q9VIF0 · NOC2L_DROME

Function

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular ComponentNoc1p-Noc2p complex
Cellular ComponentNoc2p-Noc3p complex
Cellular Componentnucleolus
Cellular Componentnucleoplasm
Molecular Functionhistone binding
Molecular Functiontranscription corepressor activity
Biological Processnegative regulation of transcription by RNA polymerase II
Biological Processribosomal large subunit biogenesis

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Nucleolar complex protein 2

Gene names

    • Name
      Noc2
    • ORF names
      CG9246

Organism names

  • Taxonomic identifier
  • Strain
    • Berkeley
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Brachycera > Muscomorpha > Ephydroidea > Drosophilidae > Drosophila > Sophophora

Accessions

  • Primary accession
    Q9VIF0

Proteomes

Organism-specific databases

Subcellular Location

Keywords

Phenotypes & Variants

Disruption phenotype

Ubiquitous RNAi-mediated knock-down is lethal between first and second instar with reduced larval size (PubMed:36314272).
Conditional RNAi-mediated knock-down in proliferating cells of the eye and antenna imaginal discs is viable but results in small eye size and disorganized ommatidia, possibly due to excessive apoptosis (PubMed:36314272).
Conditional RNAi-mediated knock-down in cells of the prothoracic gland impedes pupation, probably due to reduced ecdysone hormone levels (PubMed:36314272).
Conditional RNAi-mediated knock-down in fat body cells delays larval development, induces dyslipidemia, and is lethal between late third instar and pupal stages (PubMed:36314272).

PTM/Processing

Features

Showing features for chain, modified residue.

Type
IDPosition(s)Description
ChainPRO_00001210501-766Nucleolar complex protein 2
Modified residue101Phosphothreonine
Modified residue143Phosphoserine
Modified residue146Phosphoserine
Modified residue691Phosphoserine
Modified residue693Phosphoserine
Modified residue705Phosphoserine

Keywords

Proteomic databases

PTM databases

Expression

Gene expression databases

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for region, compositional bias.

Type
IDPosition(s)Description
Region1-73Disordered
Compositional bias10-33Basic and acidic residues
Compositional bias54-73Basic and acidic residues
Compositional bias100-115Acidic residues
Region100-154Disordered
Compositional bias116-143Basic and acidic residues
Region674-766Disordered
Compositional bias688-718Acidic residues
Compositional bias719-766Basic and acidic residues

Sequence similarities

Belongs to the NOC2 family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    766
  • Mass (Da)
    86,631
  • Last updated
    2000-05-01 v1
  • MD5 Checksum
    BA016312DBB373BE63A63D1F696EC675
MKLATKKIKTLGKSKPDLSKKKPAKDAIRKTKPQTTSETKVTPRNPKQKVAEPVKNGKTTKKGFKKSHKEELEGLKDIDPEFYDFLKNNDKKLLDFNLLDTDDDDDEEGDEEDKEDTVTKESKDDEDDEEKYHKPSKDLEVASDESDFEVDEEDDAAAGGIQKITLNLLHQWEQQLGQANISIDIVRKVIQAFNSALASISADGADGGENKHNAAAFKVVGAAAFNGVIQLCVIHLQPAIIRLLGVRPNSSLPLHKHKKWVKVRGCLRYYLTDLIRLVEQVSSPNILGVLLKHLHQMAGMVVPFSALGKTILKRLVVLWSTGDETVRVLAFLCILKITRKQQATMLNHVLKAMYLAYVRNSKFVSPNTLPGINFMRRSLVEMFALDLNVSYQHVFLYIRQLAIHLRNAVILKKKDSFQAVYNWQFINSLRLWADLLGASANKPQLQPLIYPLVTIATGVIRLIPTAQYFPLRFHCLQTLISLAKETNTYVPVLPLIVEVLKSNTFNRKHSAVSMKPVQFTCVLRLNKGQLAENGFRDEVIEQVCGLLLEYLAHESTSLAFSDLVVPTVMAIKTYLKECRNANYARKLKQLLEKIQESARFIEQQRGKSSVTFDIKDAQAVAAWEQQLRLKRTPLDVYYASWLKTHETKKRRQAAHTDEINADYDVPKLKKLPVKTGVPVRNENGEVELFPSDSEDEGDDGLHLGSDDDDDEDVQEEEEVEVEHPKAKKAKKEKPEKQKPRPATVEDDYDEAGGAVDIVKDLDLNEW

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias10-33Basic and acidic residues
Compositional bias54-73Basic and acidic residues
Compositional bias100-115Acidic residues
Compositional bias116-143Basic and acidic residues
Compositional bias688-718Acidic residues
Compositional bias719-766Basic and acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AE014134
EMBL· GenBank· DDBJ
AAF53971.1
EMBL· GenBank· DDBJ
Genomic DNA
AY061505
EMBL· GenBank· DDBJ
AAL29053.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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