Q9VHN9 · HPS5_DROME

Function

function

Has a role in the biogenesis of eye pigment granules. Eye pigment granules are specialized forms of late endosomes or lysosomes. Biogenesis of pigment granules in the eye requires molecular components required for protein delivery to lysosomes.

Miscellaneous

Pink was the second eye color gene identified by Morgan and colleagues, mutant flies were isolated in June 1910 just 2 months after isolation of the first white mutant allele. Another mutant allele of pink, peach, was isolated by Bridges in 1913, and according to a review published by Bridges and Morgan 10 years later, these alleles represented the first case of multiple allelomorphs described for an autosomal gene in Drosophila.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular ComponentBLOC-2 complex
Cellular Componentcytoplasm
Molecular Functionpigment binding
Biological Processcompound eye pigmentation
Biological Processdevelopmental pigmentation
Biological Processeye pigment biosynthetic process
Biological Processommochrome biosynthetic process
Biological Processprotein targeting to lysosome
Biological Processvisual perception

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    BLOC-2 complex member HPS5 homolog
  • Alternative names
    • Hermansky-Pudlak syndrome 5 protein homolog
    • Protein pink
    • dHPS5

Gene names

    • Name
      p
    • Synonyms
      HPS5
    • ORF names
      CG9770

Organism names

  • Taxonomic identifier
  • Strain
    • Berkeley
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Brachycera > Muscomorpha > Ephydroidea > Drosophilidae > Drosophila > Sophophora

Accessions

  • Primary accession
    Q9VHN9
  • Secondary accessions
    • Q8SXI1

Proteomes

Organism-specific databases

Subcellular Location

Phenotypes & Variants

Disruption phenotype

Flies exhibit defects in vesicular transport to lysosomes and therefore can alter eye color.

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00003027641-826BLOC-2 complex member HPS5 homolog

Proteomic databases

Expression

Tissue specificity

Expressed in eye pigment granules.

Developmental stage

Expressed throughout development, highest expression being in adult heads.

Gene expression databases

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for repeat, compositional bias, region.

TypeIDPosition(s)Description
Repeat22-61WD 1
Repeat63-102WD 2
Repeat110-149WD 3
Compositional bias422-445Polar residues
Region422-447Disordered

Sequence similarities

Belongs to the HPS5 family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    826
  • Mass (Da)
    93,620
  • Last updated
    2000-05-01 v1
  • Checksum
    C9D473DC5B228736
MADAYCLTNFIDFSLSLSLPLKHHNRIKYTCFDISDSYIIFGASSGSLYLFNRNGKFLLLIPNKHGAITSLSISANSKYVAFATQRSLICVYAVNLSAQATPQVIFTHLDQSVQVTCIHWTQDEKQFYYGDSRGQVSLVLLSSFIGHSLLFNMTVHPLLYLDSPIVQIDDFEYLLLVSNCTKCILCNTEYEDYKQIGNRPRDGAFGACFFVSPQESLQPSRIYCARPGSRVWEVDFEGEVIQTHQFKTALATAPARIQRPGSGTDELDANAELLDYQPQNLQFAKVQRLNDDFLLAFTELGLYIFDIRRSAVVLWSNQFERIADCRSSGSEIFVFTQSGALYSVQLQTLQSHAVSLIQQSKLLPCANLLRQHVRYFADKAREDYELKQLNPLKQLLIERQEYELLNDISVIFDAITQCTGSALDTHSSGGSSATTERSLSGGSSSRAPPKGVYVLENAFCDNLKQPLKTGHFKDALLTVTGKFGKNIIKYKFNIFAEEQQQLVRELIPASERSLPFKDIKARYESGSEDQEEEIVRRCKKPAPQVPHISPEEKTLYNLYLIAKSAKFSRTQCVDRYRAVFDEYAAGELVNLLEKLAQVMVEHGDTPDQAQRNCYEMYFDYLDPEMIWEVDDATRDHIAAGFVLLNTSQNAEIVKCEHCSFPLRFDTSCQYHELGAVLLRYFWSRGEQLKCFDVVQSVPALLDVLAKFYLAEQNLTKVVAIVLNYGLPELLADVGKQLSVSAWGRCFEQFVELQRGGRLVCANCECISGVEQEQLGRHFFYNWNCFLNIALDHMSAGDTLALIFKWSSYIPNDAIDREFYSRCLLKG

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
U3PV63U3PV63_DROMEp826

Features

Showing features for sequence conflict, compositional bias.

TypeIDPosition(s)Description
Sequence conflict181in Ref. 3; AAL90363
Sequence conflict346in Ref. 3; AAL90363
Compositional bias422-445Polar residues
Sequence conflict566in Ref. 3; AAL90363

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AE014297
EMBL· GenBank· DDBJ
AAF54263.1
EMBL· GenBank· DDBJ
Genomic DNA
AY089625
EMBL· GenBank· DDBJ
AAL90363.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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