Q9VHN9 · HPS5_DROME
- ProteinBLOC-2 complex member HPS5 homolog
- Genep
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids826 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score5/5
Function
function
Has a role in the biogenesis of eye pigment granules. Eye pigment granules are specialized forms of late endosomes or lysosomes. Biogenesis of pigment granules in the eye requires molecular components required for protein delivery to lysosomes.
Miscellaneous
Pink was the second eye color gene identified by Morgan and colleagues, mutant flies were isolated in June 1910 just 2 months after isolation of the first white mutant allele. Another mutant allele of pink, peach, was isolated by Bridges in 1913, and according to a review published by Bridges and Morgan 10 years later, these alleles represented the first case of multiple allelomorphs described for an autosomal gene in Drosophila.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | BLOC-2 complex | |
Cellular Component | cytoplasm | |
Molecular Function | pigment binding | |
Biological Process | compound eye pigmentation | |
Biological Process | developmental pigmentation | |
Biological Process | eye pigment biosynthetic process | |
Biological Process | ommochrome biosynthetic process | |
Biological Process | protein targeting to lysosome | |
Biological Process | visual perception |
Keywords
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameBLOC-2 complex member HPS5 homolog
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Brachycera > Muscomorpha > Ephydroidea > Drosophilidae > Drosophila > Sophophora
Accessions
- Primary accessionQ9VHN9
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Phenotypes & Variants
Disruption phenotype
Flies exhibit defects in vesicular transport to lysosomes and therefore can alter eye color.
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000302764 | 1-826 | BLOC-2 complex member HPS5 homolog | |||
Sequence: MADAYCLTNFIDFSLSLSLPLKHHNRIKYTCFDISDSYIIFGASSGSLYLFNRNGKFLLLIPNKHGAITSLSISANSKYVAFATQRSLICVYAVNLSAQATPQVIFTHLDQSVQVTCIHWTQDEKQFYYGDSRGQVSLVLLSSFIGHSLLFNMTVHPLLYLDSPIVQIDDFEYLLLVSNCTKCILCNTEYEDYKQIGNRPRDGAFGACFFVSPQESLQPSRIYCARPGSRVWEVDFEGEVIQTHQFKTALATAPARIQRPGSGTDELDANAELLDYQPQNLQFAKVQRLNDDFLLAFTELGLYIFDIRRSAVVLWSNQFERIADCRSSGSEIFVFTQSGALYSVQLQTLQSHAVSLIQQSKLLPCANLLRQHVRYFADKAREDYELKQLNPLKQLLIERQEYELLNDISVIFDAITQCTGSALDTHSSGGSSATTERSLSGGSSSRAPPKGVYVLENAFCDNLKQPLKTGHFKDALLTVTGKFGKNIIKYKFNIFAEEQQQLVRELIPASERSLPFKDIKARYESGSEDQEEEIVRRCKKPAPQVPHISPEEKTLYNLYLIAKSAKFSRTQCVDRYRAVFDEYAAGELVNLLEKLAQVMVEHGDTPDQAQRNCYEMYFDYLDPEMIWEVDDATRDHIAAGFVLLNTSQNAEIVKCEHCSFPLRFDTSCQYHELGAVLLRYFWSRGEQLKCFDVVQSVPALLDVLAKFYLAEQNLTKVVAIVLNYGLPELLADVGKQLSVSAWGRCFEQFVELQRGGRLVCANCECISGVEQEQLGRHFFYNWNCFLNIALDHMSAGDTLALIFKWSSYIPNDAIDREFYSRCLLKG |
Proteomic databases
Expression
Tissue specificity
Expressed in eye pigment granules.
Developmental stage
Expressed throughout development, highest expression being in adult heads.
Gene expression databases
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for repeat, compositional bias, region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Repeat | 22-61 | WD 1 | ||||
Sequence: KHHNRIKYTCFDISDSYIIFGASSGSLYLFNRNGKFLLLI | ||||||
Repeat | 63-102 | WD 2 | ||||
Sequence: NKHGAITSLSISANSKYVAFATQRSLICVYAVNLSAQATP | ||||||
Repeat | 110-149 | WD 3 | ||||
Sequence: DQSVQVTCIHWTQDEKQFYYGDSRGQVSLVLLSSFIGHSL | ||||||
Compositional bias | 422-445 | Polar residues | ||||
Sequence: ALDTHSSGGSSATTERSLSGGSSS | ||||||
Region | 422-447 | Disordered | ||||
Sequence: ALDTHSSGGSSATTERSLSGGSSSRA |
Sequence similarities
Belongs to the HPS5 family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length826
- Mass (Da)93,620
- Last updated2000-05-01 v1
- ChecksumC9D473DC5B228736
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
U3PV63 | U3PV63_DROME | p | 826 |
Features
Showing features for sequence conflict, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Sequence conflict | 181 | in Ref. 3; AAL90363 | ||||
Sequence: T → A | ||||||
Sequence conflict | 346 | in Ref. 3; AAL90363 | ||||
Sequence: L → Q | ||||||
Compositional bias | 422-445 | Polar residues | ||||
Sequence: ALDTHSSGGSSATTERSLSGGSSS | ||||||
Sequence conflict | 566 | in Ref. 3; AAL90363 | ||||
Sequence: K → R |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AE014297 EMBL· GenBank· DDBJ | AAF54263.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY089625 EMBL· GenBank· DDBJ | AAL90363.1 EMBL· GenBank· DDBJ | mRNA |