Q9VGH7 · CLCN2_DROME
- ProteinChloride channel protein 2
- GeneClC-a
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids1193 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score5/5
Function
function
Miscellaneous
Features
Showing features for binding site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | actin cytoskeleton | |
Cellular Component | apical plasma membrane | |
Cellular Component | basal plasma membrane | |
Cellular Component | chloride channel complex | |
Cellular Component | plasma membrane | |
Molecular Function | chloride channel activity | |
Molecular Function | voltage-gated chloride channel activity | |
Biological Process | chloride transmembrane transport | |
Biological Process | chloride transport | |
Biological Process | renal water homeostasis | |
Biological Process | renal water transport | |
Biological Process | transepithelial chloride transport | |
Biological Process | transepithelial water transport |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameChloride channel protein 2
- Short namesClC-2; DmClC-2
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Brachycera > Muscomorpha > Ephydroidea > Drosophilidae > Drosophila > Sophophora
Accessions
- Primary accessionQ9VGH7
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
Features
Showing features for topological domain, transmembrane, intramembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 1-168 | Cytoplasmic | ||||
Sequence: MVYFGDRQRDRNRDRSNQKVERIIHDEEFGEENVELVDSEWADFEKFICQLRKRRNSAMSMEEELRHVQRHPKIKSHAFYPCPPPAENARDSDSSDDDDPIGYIDTLMYGRYTKDLGEFAKDEARKLKILEKRRKQEDKQRNKELLGKHSTRAKRVSSWIWRHTVARL | ||||||
Transmembrane | 169-204 | Helical | ||||
Sequence: GEDWVFLALLGIIMALLSFIMDKGISICTNARIWLY | ||||||
Transmembrane | 213-236 | Helical | ||||
Sequence: VQYIAWVSLPVCLILFSAGFVHLI | ||||||
Intramembrane | 245-252 | Helical | ||||
Sequence: IPEMKTIL | ||||||
Transmembrane | 261-279 | Helical | ||||
Sequence: LTFKTLVAKVIGLTATLGS | ||||||
Transmembrane | 286-304 | Helical | ||||
Sequence: EGPFVHIASIVAQLLSKLV | ||||||
Intramembrane | 320-332 | Helical | ||||
Sequence: MLAAACAVGVGAC | ||||||
Intramembrane | 336-344 | Helical | ||||
Sequence: PVGGVLFSI | ||||||
Transmembrane | 356-373 | Helical | ||||
Sequence: YWRGFFAAVCGATVFRLL | ||||||
Transmembrane | 402-430 | Helical | ||||
Sequence: LFVFALIGLVCGLGGASYVWVHRRYVLFM | ||||||
Transmembrane | 439-458 | Helical | ||||
Sequence: FLQKNRFLYPGFLALLVSSI | ||||||
Transmembrane | 511-530 | Helical | ||||
Sequence: FGNLVIYTLFTFVVSIIAST | ||||||
Transmembrane | 536-555 | Helical | ||||
Sequence: GMFIPVFKIGAGFGRLVGEF | ||||||
Intramembrane | 576-590 | Helical | ||||
Sequence: GGYAVVGAAAFSGSV | ||||||
Intramembrane | 591-592 | Note=Loop between two helices | ||||
Sequence: TH | ||||||
Intramembrane | 593-604 | Helical | ||||
Sequence: TVSVAVIIFEMT | ||||||
Intramembrane | 605-609 | Note=Loop between two helices | ||||
Sequence: GQITH | ||||||
Transmembrane | 610-626 | Helical | ||||
Sequence: VVPVMIAVLVANAVAAL | ||||||
Topological domain | 627-1193 | Cytoplasmic | ||||
Sequence: LQPSIYDSIILIKKLPYLPDLLPSSSGMYSIFVEDFMVRDVKYIWHGISYQKLKEVLKLNKTLRSLPLVDSPDNMILLGSVQRYELIKMIEKHIGREKRMEVAQKWQKEAQERALEEEKKKQEVELKMRRPSRFEVLPAPDILSLRQIANDEMLPPKKRAETMHGSLAPRKSILKKTNSFNLKTYAQPMGHSPSITPYTTITGNSEFRIRSAFEAIFKKSTTLQDVQPDPETGSLSPAASNHEVEVPRTPSTPGVSKKVQLPAQSNWDFVTDQIMLQVNPISTESNKMPAEKDFTDKALSNNGDSSKQSPSIKFKANKVADVNRSPQTAKRCSKIRFANEVGVNGSPTRTKCKIKPENVLGYSIEDVDETTNPESLAESIQKPKSVRLPRERVIDMSPEDQKQWELEEMLKPIDLQKANVHIDPSPFQLVERTSILKVHSLFSMVGINHAYVTKIGRLVGVVGLKELRKAIEDINSNSFVPPTRDEDADEKPAVEKPLLSTNSSDKAVDMTVTSMDSALSNSENCSDIEMEHIKHTDKGTVSLTMPPQESKQSPSADKSNTENGNHA |
Keywords
- Cellular component
Phenotypes & Variants
Features
Showing features for natural variant.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Natural variant | 249 | in RNA edited version | ||||
Sequence: K → R | ||||||
Natural variant | 276 | in RNA edited version | ||||
Sequence: T → A | ||||||
Natural variant | 285 | in RNA edited version | ||||
Sequence: K → R | ||||||
Natural variant | 286 | in RNA edited version | ||||
Sequence: E → G |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 4 variants from UniProt as well as other sources including ClinVar and dbSNP.
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000282953 | 1-1193 | Chloride channel protein 2 | |||
Sequence: MVYFGDRQRDRNRDRSNQKVERIIHDEEFGEENVELVDSEWADFEKFICQLRKRRNSAMSMEEELRHVQRHPKIKSHAFYPCPPPAENARDSDSSDDDDPIGYIDTLMYGRYTKDLGEFAKDEARKLKILEKRRKQEDKQRNKELLGKHSTRAKRVSSWIWRHTVARLGEDWVFLALLGIIMALLSFIMDKGISICTNARIWLYRDLTSQPFVQYIAWVSLPVCLILFSAGFVHLIAPQSIGSGIPEMKTILRGVQLKEYLTFKTLVAKVIGLTATLGSGMPLGKEGPFVHIASIVAQLLSKLVTSFQGIYENESRNSEMLAAACAVGVGACFAAPVGGVLFSIEVTTTYFAVRNYWRGFFAAVCGATVFRLLAVWFQNADTVRALFLTNFTTEFPFDPQELFVFALIGLVCGLGGASYVWVHRRYVLFMRSNKRMNKFLQKNRFLYPGFLALLVSSISFPLGTGQFLAGELSTHEQVTQLFSNFTWSRDDLTVEQAAVVTHWMTSYTSVFGNLVIYTLFTFVVSIIASTIPVPSGMFIPVFKIGAGFGRLVGEFMAVTFPHGVRYGGRLSPIMPGGYAVVGAAAFSGSVTHTVSVAVIIFEMTGQITHVVPVMIAVLVANAVAALLQPSIYDSIILIKKLPYLPDLLPSSSGMYSIFVEDFMVRDVKYIWHGISYQKLKEVLKLNKTLRSLPLVDSPDNMILLGSVQRYELIKMIEKHIGREKRMEVAQKWQKEAQERALEEEKKKQEVELKMRRPSRFEVLPAPDILSLRQIANDEMLPPKKRAETMHGSLAPRKSILKKTNSFNLKTYAQPMGHSPSITPYTTITGNSEFRIRSAFEAIFKKSTTLQDVQPDPETGSLSPAASNHEVEVPRTPSTPGVSKKVQLPAQSNWDFVTDQIMLQVNPISTESNKMPAEKDFTDKALSNNGDSSKQSPSIKFKANKVADVNRSPQTAKRCSKIRFANEVGVNGSPTRTKCKIKPENVLGYSIEDVDETTNPESLAESIQKPKSVRLPRERVIDMSPEDQKQWELEEMLKPIDLQKANVHIDPSPFQLVERTSILKVHSLFSMVGINHAYVTKIGRLVGVVGLKELRKAIEDINSNSFVPPTRDEDADEKPAVEKPLLSTNSSDKAVDMTVTSMDSALSNSENCSDIEMEHIKHTDKGTVSLTMPPQESKQSPSADKSNTENGNHA |
Proteomic databases
Expression
Tissue specificity
Gene expression databases
Structure
Family & Domains
Features
Showing features for region, motif, domain, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 76-97 | Disordered | ||||
Sequence: SHAFYPCPPPAENARDSDSSDD | ||||||
Motif | 242-246 | Selectivity filter part_1 | ||||
Sequence: GSGIP | ||||||
Motif | 284-288 | Selectivity filter part_2 | ||||
Sequence: GKEGP | ||||||
Motif | 536-540 | Selectivity filter part_3 | ||||
Sequence: GMFIP | ||||||
Domain | 663-723 | CBS 1 | ||||
Sequence: MVRDVKYIWHGISYQKLKEVLKLNKTLRSLPLVDSPDNMILLGSVQRYELIKMIEKHIGRE | ||||||
Compositional bias | 848-865 | Polar residues | ||||
Sequence: TLQDVQPDPETGSLSPAA | ||||||
Region | 848-884 | Disordered | ||||
Sequence: TLQDVQPDPETGSLSPAASNHEVEVPRTPSTPGVSKK | ||||||
Domain | 1048-1105 | CBS 2 | ||||
Sequence: IDPSPFQLVERTSILKVHSLFSMVGINHAYVTKIGRLVGVVGLKELRKAIEDINSNSF | ||||||
Region | 1103-1122 | Disordered | ||||
Sequence: NSFVPPTRDEDADEKPAVEK | ||||||
Region | 1159-1193 | Disordered | ||||
Sequence: IKHTDKGTVSLTMPPQESKQSPSADKSNTENGNHA | ||||||
Compositional bias | 1167-1193 | Polar residues | ||||
Sequence: VSLTMPPQESKQSPSADKSNTENGNHA |
Sequence similarities
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence & Isoforms
- Sequence statusComplete
This entry describes 6 isoforms produced by Alternative splicing.
Q9VGH7-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- NameD
- Length1,193
- Mass (Da)133,648
- Last updated2003-06-01 v3
- Checksum6CD0508E6DBCB9A6
Q9VGH7-2
- NameA
- Differences from canonical
- 2-107: VYFGDRQRDRNRDRSNQKVERIIHDEEFGEENVELVDSEWADFEKFICQLRKRRNSAMSMEEELRHVQRHPKIKSHAFYPCPPPAENARDSDSSDDDDPIGYIDTL → FNNSHSHQDEYIREYAFEPELLINREDYQRKEERSQKSTAASSASTPVRQRWDEVIAKQKEQQRKQSIEIDPPGDDKNQIEIEIEAFYY
Q9VGH7-3
- NameF
- SynonymsB
- Differences from canonical
- 889-1015: Missing
Q9VGH7-4
- NameC
Q9VGH7-6
- NameG
Q9VGH7-7
- NameH
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A0B4KGV4 | A0A0B4KGV4_DROME | ClC-a | 221 |
Features
Showing features for alternative sequence, sequence conflict, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Alternative sequence | VSP_035041 | 1 | in isoform G and isoform H | |||
Sequence: M → MKATRNGGQLLIAPSPQTAARLLPLRTYSNASSLGHHHDRSTLSDGDEEEGGLGYTH | ||||||
Alternative sequence | VSP_035042 | 2-105 | in isoform G and isoform H | |||
Sequence: Missing | ||||||
Alternative sequence | VSP_052366 | 2-107 | in isoform A and isoform C | |||
Sequence: VYFGDRQRDRNRDRSNQKVERIIHDEEFGEENVELVDSEWADFEKFICQLRKRRNSAMSMEEELRHVQRHPKIKSHAFYPCPPPAENARDSDSSDDDDPIGYIDTL → FNNSHSHQDEYIREYAFEPELLINREDYQRKEERSQKSTAASSASTPVRQRWDEVIAKQKEQQRKQSIEIDPPGDDKNQIEIEIEAFYY | ||||||
Sequence conflict | 529 | in Ref. 4; AAQ22442 | ||||
Sequence: S → P | ||||||
Compositional bias | 848-865 | Polar residues | ||||
Sequence: TLQDVQPDPETGSLSPAA | ||||||
Alternative sequence | VSP_052367 | 889-1015 | in isoform F, isoform C and isoform G | |||
Sequence: Missing | ||||||
Compositional bias | 1167-1193 | Polar residues | ||||
Sequence: VSLTMPPQESKQSPSADKSNTENGNHA |
RNA Editing
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AE014297 EMBL· GenBank· DDBJ | AAF54701.3 EMBL· GenBank· DDBJ | Genomic DNA | ||
AE014297 EMBL· GenBank· DDBJ | AAF54702.3 EMBL· GenBank· DDBJ | Genomic DNA | ||
AE014297 EMBL· GenBank· DDBJ | AAN13532.2 EMBL· GenBank· DDBJ | Genomic DNA | ||
AE014297 EMBL· GenBank· DDBJ | ABW08644.2 EMBL· GenBank· DDBJ | Genomic DNA | ||
AE014297 EMBL· GenBank· DDBJ | ABW08645.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AE014297 EMBL· GenBank· DDBJ | ACZ94889.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY119539 EMBL· GenBank· DDBJ | AAM50193.1 EMBL· GenBank· DDBJ | mRNA | ||
BT009973 EMBL· GenBank· DDBJ | AAQ22442.1 EMBL· GenBank· DDBJ | mRNA | ||
BT030454 EMBL· GenBank· DDBJ | ABP87896.1 EMBL· GenBank· DDBJ | mRNA |