Essential maintenance is planned to begin on Fri Jan 24 2025. The website may be temporarily unavailable. Please use our fallback: https://wwwdev.ebi.ac.uk/uniprot/front-end/fallback/ in case of any outage.

Q9VCZ3 · OCTB1_DROME

Function

function

Autoreceptor for octopamine, which is a neurotransmitter, neurohormone, and neuromodulator in invertebrates (PubMed:15816867, PubMed:22553037).
Negatively regulates synaptic growth by activating the inhibitory G protein Galphao and limiting cAMP production (PubMed:22553037).
Antagonizes the action of Octbeta2R which stimulates synaptic growth (PubMed:22553037).

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentmembrane
Cellular Componentplasma membrane
Molecular Functionadrenergic receptor activity
Molecular Functionoctopamine receptor activity
Biological Processadenylate cyclase-activating adrenergic receptor signaling pathway
Biological Processadenylate cyclase-activating G protein-coupled receptor signaling pathway
Biological Processadenylate cyclase-modulating G protein-coupled receptor signaling pathway
Biological Processnegative regulation of synaptic assembly at neuromuscular junction
Biological Processpositive regulation of MAPK cascade

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Octopamine receptor beta-1R
  • Short names
    DmOA2; DmOct-beta-1R

Gene names

    • Name
      Octbeta1R
    • Synonyms
      oa2
      , Oct-beta-1
    • ORF names
      CG6919

Organism names

  • Taxonomic identifier
  • Strain
    • Berkeley
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Brachycera > Muscomorpha > Ephydroidea > Drosophilidae > Drosophila > Sophophora

Accessions

  • Primary accession
    Q9VCZ3
  • Secondary accessions
    • A0A0B4KHN2
    • Q2PDQ3
    • Q4LBC0

Proteomes

Organism-specific databases

Subcellular Location

Features

Showing features for topological domain, transmembrane.

Type
IDPosition(s)Description
Topological domain1-111Extracellular
Transmembrane112-132Helical; Name=1
Topological domain133-139Cytoplasmic
Transmembrane140-160Helical; Name=2
Topological domain161-186Extracellular
Transmembrane187-209Helical; Name=3
Topological domain210-223Cytoplasmic
Transmembrane224-244Helical; Name=4
Topological domain245-270Extracellular
Transmembrane271-291Helical; Name=5
Topological domain292-351Cytoplasmic
Transmembrane352-372Helical; Name=6
Topological domain373-383Extracellular
Transmembrane384-404Helical; Name=7
Topological domain405-508Cytoplasmic

Keywords

Phenotypes & Variants

Disruption phenotype

Fails to respond to starvation by increasing locomotor activity. Decreased basal levels of locomotion. Overgrowth of octopaminergic and glutamatergic (type I and type II) neuromuscular junctions. Increase in the number of terminal type I and type II boutons and in the motile filopodia-like extensions (synaptopods) which form during the expansion of type II terminals in developing larvae.

PTM/Processing

Features

Showing features for chain, glycosylation.

Type
IDPosition(s)Description
ChainPRO_00000699591-508Octopamine receptor beta-1R
Glycosylation164N-linked (GlcNAc...) asparagine

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

In the adult, expressed in the superior protocerebrum and the optic lobe medulla of the central nervous system, nurse cells of egg chambers in the ovary at oogenic stages 1-10, and spermatogonia and spermatocytes in the testis (PubMed:22303848).
Expressed in embryonic and larval ventral nerve cord and brain lobe, and the larval imaginal disk and larval salivary gland (PubMed:22303848).
Also expressed in larval synaptic boutons and retinal cells in the optic disk (PubMed:22553037).

Developmental stage

Expressed in adult, pupae, third instar larvae, and 0-4 hour and 0-18 hour old embryos (PubMed:15816867, PubMed:22303848).
Levels increase significantly at the late embryonic stage, gradually decrease during postembryonic development and increase slightly in the adult (PubMed:22303848).

Gene expression databases

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region440-464Disordered

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Keywords

Phylogenomic databases

Family and domain databases

Protein family/group databases

Sequence & Isoform

Align isoforms (2)
  • Sequence status
    Complete

This entry describes 2 isoforms produced by Alternative splicing.

Q9VCZ3-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Length
    508
  • Mass (Da)
    56,855
  • Last updated
    2000-05-01 v1
  • MD5 Checksum
    250F31210A9785195415B8D0B484192C
MTLLQRLQAMSATTTRTILEGSISSFGGGTNEPLASKIPVLEESASHARYLKFIADGLIDEGLGSAVGSGSSIAVSVEDVVAGQAQDIQASEGSTDDADGSSHLALVFVKCFIIGFIILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALCAMTFNASVMISGKWMFGSVMCDMWNSFDVYFSTASIMHLCCISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLSPALLSFLPICSGWYTTTENYKYLKSNPHICEFKVNKAYAIVSSSMSFWIPGIVMLSMYYRIYQEADRQERLVYRSKVAALLLEKHLQISQIPKPRPSIQVEQSTISTMRRERKAARTLGIIMSAFLICWLPFFLWYIVSSLCDSCITPRLLVGILFWIGYFNSALNPIIYAYFNRDFRAAFKKTLKSLFPYAFYFCRRGRGRDDDRDLEFGGPSRRGTNGAQRTGSGSAEMANCVNSTASSEIHMSVMRARQYAVNVTPTTDAQMQQLHPLYTN

Q9VCZ3-2

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
E1JIT6E1JIT6_DROMEOctbeta1R428

Features

Showing features for alternative sequence.

TypeIDPosition(s)Description
Alternative sequenceVSP_051833421in isoform B
Alternative sequenceVSP_051834422-508in isoform B

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AJ617526
EMBL· GenBank· DDBJ
CAE84925.1
EMBL· GenBank· DDBJ
mRNA
AJ880687
EMBL· GenBank· DDBJ
CAI56428.1
EMBL· GenBank· DDBJ
mRNA
AJ880688
EMBL· GenBank· DDBJ
CAI56429.1
EMBL· GenBank· DDBJ
mRNA
AE014297
EMBL· GenBank· DDBJ
AAF56012.1
EMBL· GenBank· DDBJ
Genomic DNA
AE014297
EMBL· GenBank· DDBJ
ABC66185.1
EMBL· GenBank· DDBJ
Genomic DNA
AE014297
EMBL· GenBank· DDBJ
AGB96223.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
Help