Q9VCZ3 · OCTB1_DROME
- ProteinOctopamine receptor beta-1R
- GeneOctbeta1R
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids508 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score5/5
Function
function
Autoreceptor for octopamine, which is a neurotransmitter, neurohormone, and neuromodulator in invertebrates (PubMed:15816867, PubMed:22553037).
Negatively regulates synaptic growth by activating the inhibitory G protein Galphao and limiting cAMP production (PubMed:22553037).
Antagonizes the action of Octbeta2R which stimulates synaptic growth (PubMed:22553037).
Negatively regulates synaptic growth by activating the inhibitory G protein Galphao and limiting cAMP production (PubMed:22553037).
Antagonizes the action of Octbeta2R which stimulates synaptic growth (PubMed:22553037).
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | membrane | |
Cellular Component | plasma membrane | |
Molecular Function | adrenergic receptor activity | |
Molecular Function | octopamine receptor activity | |
Biological Process | adenylate cyclase-activating adrenergic receptor signaling pathway | |
Biological Process | adenylate cyclase-activating G protein-coupled receptor signaling pathway | |
Biological Process | adenylate cyclase-modulating G protein-coupled receptor signaling pathway | |
Biological Process | negative regulation of synaptic assembly at neuromuscular junction | |
Biological Process | positive regulation of MAPK cascade |
Keywords
- Molecular function
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameOctopamine receptor beta-1R
- Short namesDmOA2; DmOct-beta-1R
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Brachycera > Muscomorpha > Ephydroidea > Drosophilidae > Drosophila > Sophophora
Accessions
- Primary accessionQ9VCZ3
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Multi-pass membrane protein
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Topological domain | 1-111 | Extracellular | |||
Transmembrane | 112-132 | Helical; Name=1 | |||
Topological domain | 133-139 | Cytoplasmic | |||
Transmembrane | 140-160 | Helical; Name=2 | |||
Topological domain | 161-186 | Extracellular | |||
Transmembrane | 187-209 | Helical; Name=3 | |||
Topological domain | 210-223 | Cytoplasmic | |||
Transmembrane | 224-244 | Helical; Name=4 | |||
Topological domain | 245-270 | Extracellular | |||
Transmembrane | 271-291 | Helical; Name=5 | |||
Topological domain | 292-351 | Cytoplasmic | |||
Transmembrane | 352-372 | Helical; Name=6 | |||
Topological domain | 373-383 | Extracellular | |||
Transmembrane | 384-404 | Helical; Name=7 | |||
Topological domain | 405-508 | Cytoplasmic | |||
Keywords
- Cellular component
Phenotypes & Variants
Disruption phenotype
Fails to respond to starvation by increasing locomotor activity. Decreased basal levels of locomotion. Overgrowth of octopaminergic and glutamatergic (type I and type II) neuromuscular junctions. Increase in the number of terminal type I and type II boutons and in the motile filopodia-like extensions (synaptopods) which form during the expansion of type II terminals in developing larvae.
Expression
Tissue specificity
In the adult, expressed in the superior protocerebrum and the optic lobe medulla of the central nervous system, nurse cells of egg chambers in the ovary at oogenic stages 1-10, and spermatogonia and spermatocytes in the testis (PubMed:22303848).
Expressed in embryonic and larval ventral nerve cord and brain lobe, and the larval imaginal disk and larval salivary gland (PubMed:22303848).
Also expressed in larval synaptic boutons and retinal cells in the optic disk (PubMed:22553037).
Expressed in embryonic and larval ventral nerve cord and brain lobe, and the larval imaginal disk and larval salivary gland (PubMed:22303848).
Also expressed in larval synaptic boutons and retinal cells in the optic disk (PubMed:22553037).
Developmental stage
Expressed in adult, pupae, third instar larvae, and 0-4 hour and 0-18 hour old embryos (PubMed:15816867, PubMed:22303848).
Levels increase significantly at the late embryonic stage, gradually decrease during postembryonic development and increase slightly in the adult (PubMed:22303848).
Levels increase significantly at the late embryonic stage, gradually decrease during postembryonic development and increase slightly in the adult (PubMed:22303848).
Gene expression databases
Structure
Family & Domains
Features
Showing features for region.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Region | 440-464 | Disordered | |||
Sequence similarities
Belongs to the G-protein coupled receptor 1 family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Protein family/group databases
Sequence & Isoform
- Sequence statusComplete
This entry describes 2 isoforms produced by Alternative splicing.
Q9VCZ3-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- NameA
- Length508
- Mass (Da)56,855
- Last updated2000-05-01 v1
- MD5 Checksum250F31210A9785195415B8D0B484192C
Q9VCZ3-2
- NameB
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
E1JIT6 | E1JIT6_DROME | Octbeta1R | 428 |
Features
Showing features for alternative sequence.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Alternative sequence | VSP_051833 | 421 | in isoform B | ||
Alternative sequence | VSP_051834 | 422-508 | in isoform B | ||
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AJ617526 EMBL· GenBank· DDBJ | CAE84925.1 EMBL· GenBank· DDBJ | mRNA | ||
AJ880687 EMBL· GenBank· DDBJ | CAI56428.1 EMBL· GenBank· DDBJ | mRNA | ||
AJ880688 EMBL· GenBank· DDBJ | CAI56429.1 EMBL· GenBank· DDBJ | mRNA | ||
AE014297 EMBL· GenBank· DDBJ | AAF56012.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AE014297 EMBL· GenBank· DDBJ | ABC66185.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AE014297 EMBL· GenBank· DDBJ | AGB96223.1 EMBL· GenBank· DDBJ | Genomic DNA |