Q9VCY8 · ADRL_DROME
- ProteinAdiponectin receptor protein
- GeneAdipoR
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids444 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Adiponectin receptor. In insulin-producing cells, regulates insulin secretion and controls glucose and lipid metabolism.
Features
Showing features for binding site.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | membrane | |
Cellular Component | plasma membrane | |
Molecular Function | metal ion binding | |
Molecular Function | protein-hormone receptor activity | |
Molecular Function | signaling receptor activity | |
Biological Process | adiponectin-activated signaling pathway | |
Biological Process | fatty acid oxidation | |
Biological Process | female germ-line stem cell population maintenance | |
Biological Process | glucose homeostasis | |
Biological Process | hormone-mediated signaling pathway | |
Biological Process | positive regulation of insulin secretion | |
Biological Process | triglyceride homeostasis |
Keywords
- Molecular function
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameAdiponectin receptor protein
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Brachycera > Muscomorpha > Ephydroidea > Drosophilidae > Drosophila > Sophophora
Accessions
- Primary accessionQ9VCY8
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Multi-pass membrane protein
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 1-204 | Cytoplasmic | ||||
Sequence: MDSATNLLEQQGSAADVSGGSHPAEVEVTTQARATFGMDAEGHATGEAVTTTTATLRREGSDEDIFEQVQMILRKRRGWGPEDSLSPNDLDILEYDDELVEEDDAGCPLPSTPEDTQLIEAEMTEVLKAGVLSDEIDLGALAHNAAEQAEEFVRKVWEASWKVCHYKNLPKWLQDNDFLHRGHRPPLPSFRACFKSIFRVHTET | ||||||
Transmembrane | 205-225 | Helical; Name=1 | ||||
Sequence: GNIWTHLLGCIAFIGVALYFI | ||||||
Topological domain | 226-237 | Extracellular | ||||
Sequence: SRPSVEIQTQEK | ||||||
Transmembrane | 238-258 | Helical; Name=2 | ||||
Sequence: IVFGAFFIGAIVCLGFSFAFH | ||||||
Topological domain | 259-276 | Cytoplasmic | ||||
Sequence: TLSCHSVEMGRLFSKLDY | ||||||
Transmembrane | 277-297 | Helical; Name=3 | ||||
Sequence: CGIALLIMGSFVPWLYYGFYC | ||||||
Topological domain | 298-302 | Extracellular | ||||
Sequence: HYQPK | ||||||
Transmembrane | 303-323 | Helical; Name=4 | ||||
Sequence: VIYLSVVSILGILSIVVSLWD | ||||||
Topological domain | 324-334 | Cytoplasmic | ||||
Sequence: KFSEPALRPLR | ||||||
Transmembrane | 335-355 | Helical; Name=5 | ||||
Sequence: AGVFMSFGLSGVIPAIHYSIM | ||||||
Topological domain | 356-365 | Extracellular | ||||
Sequence: EGWFSQMSRA | ||||||
Transmembrane | 366-386 | Helical; Name=6 | ||||
Sequence: SLGWLILMGLLYILGALLYAL | ||||||
Topological domain | 387-405 | Cytoplasmic | ||||
Sequence: RVPERWFPGKFDIWGQSHQ | ||||||
Transmembrane | 406-426 | Helical; Name=7 | ||||
Sequence: IFHILVIAAAFVHYHGISEMA | ||||||
Topological domain | 427-444 | Extracellular | ||||
Sequence: MYRVMYSECTVPIEPITF |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000218832 | 1-444 | Adiponectin receptor protein | |||
Sequence: MDSATNLLEQQGSAADVSGGSHPAEVEVTTQARATFGMDAEGHATGEAVTTTTATLRREGSDEDIFEQVQMILRKRRGWGPEDSLSPNDLDILEYDDELVEEDDAGCPLPSTPEDTQLIEAEMTEVLKAGVLSDEIDLGALAHNAAEQAEEFVRKVWEASWKVCHYKNLPKWLQDNDFLHRGHRPPLPSFRACFKSIFRVHTETGNIWTHLLGCIAFIGVALYFISRPSVEIQTQEKIVFGAFFIGAIVCLGFSFAFHTLSCHSVEMGRLFSKLDYCGIALLIMGSFVPWLYYGFYCHYQPKVIYLSVVSILGILSIVVSLWDKFSEPALRPLRAGVFMSFGLSGVIPAIHYSIMEGWFSQMSRASLGWLILMGLLYILGALLYALRVPERWFPGKFDIWGQSHQIFHILVIAAAFVHYHGISEMAMYRVMYSECTVPIEPITF |
Proteomic databases
Expression
Tissue specificity
In larval and adult brain, expressed in insulin-producing cells and in neurons of the subesophageal region. Also expressed in lateral neurons of the adult brain (at protein level). In third instar larvae, expressed in central nervous system (CNS), imaginal disk, salivary gland, fat body, gut and malphigian tubules.
Developmental stage
Expressed throughout development and in adult.
Gene expression databases
Structure
Family & Domains
Features
Showing features for compositional bias, region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 1-17 | Polar residues | ||||
Sequence: MDSATNLLEQQGSAADV | ||||||
Region | 1-24 | Disordered | ||||
Sequence: MDSATNLLEQQGSAADVSGGSHPA |
Sequence similarities
Belongs to the ADIPOR family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence & Isoform
- Sequence statusComplete
This entry describes 2 isoforms produced by Alternative splicing.
Q9VCY8-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- Length444
- Mass (Da)49,757
- Last updated2001-03-01 v2
- ChecksumAAFFE1C9DA935A02
Q9VCY8-2
- Name2
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A4V392 | A4V392_DROME | AdipoR | 444 |
Features
Showing features for compositional bias, alternative sequence.
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AE014297 EMBL· GenBank· DDBJ | AAF56016.2 EMBL· GenBank· DDBJ | Genomic DNA | ||
AE014297 EMBL· GenBank· DDBJ | AAF56017.3 EMBL· GenBank· DDBJ | Genomic DNA | ||
BI585801 EMBL· GenBank· DDBJ | - | mRNA | No translation available. | |
BT001487 EMBL· GenBank· DDBJ | AAN71242.1 EMBL· GenBank· DDBJ | mRNA |