Q9VCY8 · ADRL_DROME

Function

function

Adiponectin receptor. In insulin-producing cells, regulates insulin secretion and controls glucose and lipid metabolism.

Features

Showing features for binding site.

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TypeIDPosition(s)Description
Binding site258Zn2+ (UniProtKB | ChEBI)
Binding site404Zn2+ (UniProtKB | ChEBI)
Binding site408Zn2+ (UniProtKB | ChEBI)

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentmembrane
Cellular Componentplasma membrane
Molecular Functionmetal ion binding
Molecular Functionprotein-hormone receptor activity
Molecular Functionsignaling receptor activity
Biological Processadiponectin-activated signaling pathway
Biological Processfatty acid oxidation
Biological Processfemale germ-line stem cell population maintenance
Biological Processglucose homeostasis
Biological Processhormone-mediated signaling pathway
Biological Processpositive regulation of insulin secretion
Biological Processtriglyceride homeostasis

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Adiponectin receptor protein

Gene names

    • Name
      AdipoR
    • ORF names
      CG5315

Organism names

  • Taxonomic identifier
  • Strain
    • Berkeley
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Brachycera > Muscomorpha > Ephydroidea > Drosophilidae > Drosophila > Sophophora

Accessions

  • Primary accession
    Q9VCY8
  • Secondary accessions
    • Q9VCY9

Proteomes

Organism-specific databases

Subcellular Location

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain1-204Cytoplasmic
Transmembrane205-225Helical; Name=1
Topological domain226-237Extracellular
Transmembrane238-258Helical; Name=2
Topological domain259-276Cytoplasmic
Transmembrane277-297Helical; Name=3
Topological domain298-302Extracellular
Transmembrane303-323Helical; Name=4
Topological domain324-334Cytoplasmic
Transmembrane335-355Helical; Name=5
Topological domain356-365Extracellular
Transmembrane366-386Helical; Name=6
Topological domain387-405Cytoplasmic
Transmembrane406-426Helical; Name=7
Topological domain427-444Extracellular

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00002188321-444Adiponectin receptor protein

Proteomic databases

Expression

Tissue specificity

In larval and adult brain, expressed in insulin-producing cells and in neurons of the subesophageal region. Also expressed in lateral neurons of the adult brain (at protein level). In third instar larvae, expressed in central nervous system (CNS), imaginal disk, salivary gland, fat body, gut and malphigian tubules.

Developmental stage

Expressed throughout development and in adult.

Gene expression databases

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for compositional bias, region.

TypeIDPosition(s)Description
Compositional bias1-17Polar residues
Region1-24Disordered

Sequence similarities

Belongs to the ADIPOR family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence & Isoform

Align isoforms (2)
  • Sequence status
    Complete

This entry describes 2 isoforms produced by Alternative splicing.

Q9VCY8-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Length
    444
  • Mass (Da)
    49,757
  • Last updated
    2001-03-01 v2
  • Checksum
    AAFFE1C9DA935A02
MDSATNLLEQQGSAADVSGGSHPAEVEVTTQARATFGMDAEGHATGEAVTTTTATLRREGSDEDIFEQVQMILRKRRGWGPEDSLSPNDLDILEYDDELVEEDDAGCPLPSTPEDTQLIEAEMTEVLKAGVLSDEIDLGALAHNAAEQAEEFVRKVWEASWKVCHYKNLPKWLQDNDFLHRGHRPPLPSFRACFKSIFRVHTETGNIWTHLLGCIAFIGVALYFISRPSVEIQTQEKIVFGAFFIGAIVCLGFSFAFHTLSCHSVEMGRLFSKLDYCGIALLIMGSFVPWLYYGFYCHYQPKVIYLSVVSILGILSIVVSLWDKFSEPALRPLRAGVFMSFGLSGVIPAIHYSIMEGWFSQMSRASLGWLILMGLLYILGALLYALRVPERWFPGKFDIWGQSHQIFHILVIAAAFVHYHGISEMAMYRVMYSECTVPIEPITF

Q9VCY8-2

  • Name
    2
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical
    • 1-82: Missing
    • 83-122: DSLSPNDLDILEYDDELVEEDDAGCPLPSTPEDTQLIEAE → MQTQPEVIVRVNPDLEPDLSQETYRTQNPDTVKEQAENAV

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
A4V392A4V392_DROMEAdipoR444

Features

Showing features for compositional bias, alternative sequence.

TypeIDPosition(s)Description
Compositional bias1-17Polar residues
Alternative sequenceVSP_0088891-82in isoform 2
Alternative sequenceVSP_00889083-122in isoform 2

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AE014297
EMBL· GenBank· DDBJ
AAF56016.2
EMBL· GenBank· DDBJ
Genomic DNA
AE014297
EMBL· GenBank· DDBJ
AAF56017.3
EMBL· GenBank· DDBJ
Genomic DNA
BI585801
EMBL· GenBank· DDBJ
-mRNA No translation available.
BT001487
EMBL· GenBank· DDBJ
AAN71242.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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