Q9VB46 · APMAP_DROME
- ProteinAdipocyte plasma membrane-associated protein Hemomucin
- GeneHmu
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids579 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Transmembrane mucin that may be involved in cellular adhesion and the innate immune response (PubMed:12769978, PubMed:8662683).
Membrane-tethered mucins are involved in many cell surface functions and form a physical barrier around cells to regulate cell-cell and/or cell-substrate interactions, and protect against pathogens or harmful extracellular conditions (PubMed:11164341, PubMed:12769978, PubMed:8662683).
This mucin likely acts in hemocyte adhesion as it is released from hemocytes during coagulation and is also able to bind lipophorin particles which form part of the hemocyte coagulogen (PubMed:12769978).
Able to induce expression of the antibacterial proteins in the presence of GalNAc-specific lectins and so probably also functions in the innate immune response (PubMed:8662683).
Membrane-tethered mucins are involved in many cell surface functions and form a physical barrier around cells to regulate cell-cell and/or cell-substrate interactions, and protect against pathogens or harmful extracellular conditions (PubMed:11164341, PubMed:12769978, PubMed:8662683).
This mucin likely acts in hemocyte adhesion as it is released from hemocytes during coagulation and is also able to bind lipophorin particles which form part of the hemocyte coagulogen (PubMed:12769978).
Able to induce expression of the antibacterial proteins in the presence of GalNAc-specific lectins and so probably also functions in the innate immune response (PubMed:8662683).
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cell surface | |
Cellular Component | endomembrane system | |
Cellular Component | plasma membrane | |
Molecular Function | arylesterase activity | |
Molecular Function | hydrolase activity | |
Molecular Function | strictosidine synthase activity | |
Biological Process | biosynthetic process |
Keywords
- Molecular function
Names & Taxonomy
Protein names
- Recommended nameAdipocyte plasma membrane-associated protein Hemomucin
- Alternative names
Gene names
Organism names
- Strains
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Brachycera > Muscomorpha > Ephydroidea > Drosophilidae > Drosophila > Sophophora
Accessions
- Primary accessionQ9VB46
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Single-pass membrane protein
Note: Detected on membrane of hemocytes.
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 1-6 | Cytoplasmic | ||||
Sequence: MGLLYA | ||||||
Transmembrane | 7-29 | Helical | ||||
Sequence: LRVRIMNFMIFFLLIILMPGLPP | ||||||
Topological domain | 30-579 | Extracellular | ||||
Sequence: RTTFPFKDYIVTPPKDLKGALESNFHLEGAERLLEGRVYGPECLIARNNEIYTGIHGGEVIKLTSNHVTHVTKIGQPCEDIYEESRCGRPLGLAFDTQGNNLIIADAYYGLWQVDLGTNKKTLLVSPAQELAGKSINRPAKIFNGVTVSKEGDVYWTDSSSDFTIEDLVFASFANPSGRLFKYNRSKNVSEVLLDELAFANGLALSPNEDFIVVAETGAMRLTKYHLKGAKAGQSEVFVDGLPGLPDNLTPDAEGIWVPLVQSADSEHPNGFTLFTRFPSVRLFLARMLALFELPFRYLNSVYPNKFSQRFVHFVGHMESITVLAPKRTTVVRVDWNGNIVGSLHGFDKSAATVSHVLEFQDFLFLGSPTNQYLARVKSPKAKQPTLKVRNVRVEGEGLEASIGVPPSKATPKPKAAPSTTTPKPTTTTTTTTPKPTTKTTTTTTTPKPTTTTTTKKPTTTTTTTTTTPKPTTTKPPTAKPSTTTTTTTTPKPTTTTTPTTPTPEPSKPKVKRTVPEKPAPVEEDIPSDTQPPKKEKLKVINKQGVNVEL |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain, glycosylation.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000454230 | 1-579 | Adipocyte plasma membrane-associated protein Hemomucin | |||
Sequence: MGLLYALRVRIMNFMIFFLLIILMPGLPPRTTFPFKDYIVTPPKDLKGALESNFHLEGAERLLEGRVYGPECLIARNNEIYTGIHGGEVIKLTSNHVTHVTKIGQPCEDIYEESRCGRPLGLAFDTQGNNLIIADAYYGLWQVDLGTNKKTLLVSPAQELAGKSINRPAKIFNGVTVSKEGDVYWTDSSSDFTIEDLVFASFANPSGRLFKYNRSKNVSEVLLDELAFANGLALSPNEDFIVVAETGAMRLTKYHLKGAKAGQSEVFVDGLPGLPDNLTPDAEGIWVPLVQSADSEHPNGFTLFTRFPSVRLFLARMLALFELPFRYLNSVYPNKFSQRFVHFVGHMESITVLAPKRTTVVRVDWNGNIVGSLHGFDKSAATVSHVLEFQDFLFLGSPTNQYLARVKSPKAKQPTLKVRNVRVEGEGLEASIGVPPSKATPKPKAAPSTTTPKPTTTTTTTTPKPTTKTTTTTTTPKPTTTTTTKKPTTTTTTTTTTPKPTTTKPPTAKPSTTTTTTTTPKPTTTTTPTTPTPEPSKPKVKRTVPEKPAPVEEDIPSDTQPPKKEKLKVINKQGVNVEL | ||||||
Glycosylation | 213 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 217 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N |
Post-translational modification
O-glycosylated. Glycosylated in the ovary of 4 day old females.
Phosphorylated.
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Tissue specificity
Detected in ovaries (at protein level) (PubMed:11164341).
In larvae, detected in the fat body, salivary glands, imaginal disks and gut (at protein level) (PubMed:11164341).
In adults, expressed in the cardia, and in regions of the ventriculus including the area posterior to the cardia (PubMed:8662683).
In females also expressed in follicle cells (PubMed:8662683).
In larvae, detected in the fat body, salivary glands, imaginal disks and gut (at protein level) (PubMed:11164341).
In adults, expressed in the cardia, and in regions of the ventriculus including the area posterior to the cardia (PubMed:8662683).
In females also expressed in follicle cells (PubMed:8662683).
Induction
By ecdysone; in embryonic cell lines.
Developmental stage
Detected throughout development and in adults (at protein level) (PubMed:11164341).
Expressed in embryos, larvae and adults (PubMed:8662683).
Expressed in embryos, larvae and adults (PubMed:8662683).
Gene expression databases
Interaction
Structure
Family & Domains
Features
Showing features for region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 427-579 | Disordered | ||||
Sequence: GLEASIGVPPSKATPKPKAAPSTTTPKPTTTTTTTTPKPTTKTTTTTTTPKPTTTTTTKKPTTTTTTTTTTPKPTTTKPPTAKPSTTTTTTTTPKPTTTTTPTTPTPEPSKPKVKRTVPEKPAPVEEDIPSDTQPPKKEKLKVINKQGVNVEL | ||||||
Compositional bias | 443-525 | Polar residues | ||||
Sequence: PKAAPSTTTPKPTTTTTTTTPKPTTKTTTTTTTPKPTTTTTTKKPTTTTTTTTTTPKPTTTKPPTAKPSTTTTTTTTPKPTTT | ||||||
Compositional bias | 539-571 | Basic and acidic residues | ||||
Sequence: KVKRTVPEKPAPVEEDIPSDTQPPKKEKLKVIN |
Sequence similarities
Belongs to the strictosidine synthase family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length579
- Mass (Da)63,416
- Last updated2000-05-01 v1
- Checksum7584B7C08D31490B
Sequence caution
Features
Showing features for sequence conflict, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Sequence conflict | 207 | in Ref. 5; ADB25328 | ||||
Sequence: G → A | ||||||
Sequence conflict | 255 | in Ref. 4; AAM48401 | ||||
Sequence: H → Q | ||||||
Sequence conflict | 341 | in Ref. 1; AAC47118 | ||||
Sequence: V → I | ||||||
Sequence conflict | 383 | in Ref. 1; AAC47118 | ||||
Sequence: V → I | ||||||
Sequence conflict | 387 | in Ref. 5; ADB25328 | ||||
Sequence: L → Q | ||||||
Compositional bias | 443-525 | Polar residues | ||||
Sequence: PKAAPSTTTPKPTTTTTTTTPKPTTKTTTTTTTPKPTTTTTTKKPTTTTTTTTTTPKPTTTKPPTAKPSTTTTTTTTPKPTTT | ||||||
Sequence conflict | 516 | in Ref. 1; AAC47118 | ||||
Sequence: T → P | ||||||
Sequence conflict | 532 | in Ref. 1; AAC47118 | ||||
Sequence: T → TTPT | ||||||
Compositional bias | 539-571 | Basic and acidic residues | ||||
Sequence: KVKRTVPEKPAPVEEDIPSDTQPPKKEKLKVIN | ||||||
Sequence conflict | 554 | in Ref. 1; AAC47118 | ||||
Sequence: D → E |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
U42014 EMBL· GenBank· DDBJ | AAC47118.1 EMBL· GenBank· DDBJ | mRNA | ||
AE014297 EMBL· GenBank· DDBJ | AAF56697.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY118372 EMBL· GenBank· DDBJ | AAM48401.1 EMBL· GenBank· DDBJ | mRNA | ||
BT120112 EMBL· GenBank· DDBJ | ADB25328.1 EMBL· GenBank· DDBJ | mRNA | Frameshift | |
BT133185 EMBL· GenBank· DDBJ | AFA28426.1 EMBL· GenBank· DDBJ | mRNA |