Q9VAI2 · Q9VAI2_DROME

Function

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

  • Endopeptidase of broad specificity.
    EC:3.4.24.81 (UniProtKB | ENZYME | Rhea)

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Features

Showing features for binding site, active site.

115372004006008001,0001,2001,400
TypeIDPosition(s)Description
Binding site642Zn2+ (UniProtKB | ChEBI); catalytic
Active site643
Binding site646Zn2+ (UniProtKB | ChEBI); catalytic
Binding site652Zn2+ (UniProtKB | ChEBI); catalytic

GO annotations

AspectTerm
Cellular Componentmembrane
Cellular Componentplasma membrane
Molecular Functionmetal ion binding
Molecular Functionmetalloendopeptidase activity
Biological Processmembrane protein ectodomain proteolysis
Biological ProcessNotch signaling pathway

Keywords

Enzyme and pathway databases

Protein family/group databases

Names & Taxonomy

Protein names

  • Recommended name
    ADAM10 endopeptidase
  • EC number

Gene names

    • Name
      Kul
    • Synonyms
      ADAM10
      , CT3146
      , Dmel\CG1964
      , kul
    • ORF names
      CG1964
      , Dmel_CG1964

Organism names

  • Taxonomic identifier
  • Strain
    • Berkeley
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Brachycera > Muscomorpha > Ephydroidea > Drosophilidae > Drosophila > Sophophora

Accessions

  • Primary accession
    Q9VAI2

Proteomes

Organism-specific databases

Subcellular Location

Membrane
; Single-pass type I membrane protein

PTM/Processing

Features

Showing features for signal, chain.

TypeIDPosition(s)Description
Signal1-26
ChainPRO_501510002527-1537ADAM10 endopeptidase

Keywords

Proteomic databases

Expression

Gene expression databases

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for region, compositional bias, domain.

TypeIDPosition(s)Description
Region260-286Disordered
Compositional bias272-286Polar residues
Region300-348Disordered
Domain479-696Peptidase M12B
Domain711-807Disintegrin
Region1021-1062Disordered
Compositional bias1022-1038Polar residues
Compositional bias1039-1062Basic and acidic residues
Region1070-1089Disordered
Region1116-1148Disordered
Compositional bias1122-1148Polar residues
Region1173-1207Disordered
Compositional bias1186-1207Polar residues
Region1225-1323Disordered
Compositional bias1254-1323Polar residues
Compositional bias1336-1359Polar residues
Region1336-1537Disordered
Compositional bias1369-1487Polar residues
Compositional bias1503-1523Polar residues

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,537
  • Mass (Da)
    168,797
  • Last updated
    2000-05-01 v1
  • Checksum
    46A52344A8E73617
MSWLLGLLGLQVLFLWLLWLPGEILAIPTPLKLPGYTHRLTPYIKHWEAANFDRQVLQAAQVRHLEQARFRQKREVTPSASGLAHTIRLNFSAHDRDFRLVLRQQPHSVFAHDVEIENTLGPIDYDVSRIYTGSLEDDEAAHVQAILTSDNLLDGTIETQAEHYYIEPAHRYSQQLAESGVHSIVYKLSDVNMQKQQFTGGGLNSATPAKTHCASEKLRKKRWLPEELAMSDAPAPTYNRNPPLPLDLEVPYNDDFRVLASEEDKSEESPRKYPTTSTTRSTVRSTESFLATLTKPTSNRNILVNNYNPSNLGEGSRSYSSGNNNANSNSNNNNSNNNNNNNNSNNNVRKLYTKHKNIIVSTYNRPIEPEFGTPYEEPNNNGTRELPSNFFNANWTTLFLGNNNNGNDRPSHKTHVEIITKNGATKKPNIIVNNYNPEIIFAPNPHNPSFNSMMMTNLLSGRGGEDIHSSPRLLYDRKTTCMLYLQADHTFFQKMGSDEASIEAITRHVQRANTIYRNTDFNNDGKPDNITFMIKRIKVHNMNAMKDPSYRFPGNYGVEKFLELFSEEDYDAFCLAYMFTYRDFEMGTLGLAWTGDLKNAGGVCEKNGHYRGSLKSLNTGIVTLLNYGKHVPPAVSHVTLAHEIGHNFGSPHDPEQCTPGGEDGNFIMFARATSGDKKNNNKFSTCSLKSIEPVLNAKARSMKGCFTEPQSSICGNGVVEPGEQCDCGWEEDCKDSCCFPMSRQPRLDETPCTLTPHARCSPSQGPCCTTDCKLKFGDKCRDDNGCRDPSFCDGRVPQCPPSVNKPNKTICNKEFVCYMGDCTGSICLAYGLESCQCIPGPQDDRIKSCELCCKLPGEDSPCRSSFEWNEAPFDVPDMYSKPGTPCNDYNGYCDVFQKCREVDPSGPLATLRKLLLSEESIASFKKWMQHNWYTVALAAVGVILLLALSTKLLAKRSNLKLKSVTIIHSATTETVRLPENNNGVIVHTAVRTKVPFKKKVRGERTKKPGTGAGVTAAAAVGTRNAAKSSANPEPKKTTRSQAMAKKKSFEEEPKKSSKKVGKHMKEIIDYSNRNNNGDDASNLSTTNNHTNTFGKVQKWLLESPIVAQPLSHIEHSSRVRKVMSKSQSTPERLVQKTPQKTKSMGNLSNEKVKLQVVYKPPFKFSLRLSKKPKVKTHVVGAGVRPKRSQKTSNRTGGQSSSKEVSTRAKRSALLLCNEAEDDNQILTLNEPNYETLKPPTPPRSMEHCYENVDMQAEASSSKPSSSSKVAPSSQNRASLEVTPPVTAQRNSYRRSNSLSTHNPFAAAPRRSSSKASGSVNLTRNFGSTQNLINLSQNLSKNKKRSSLNLKASGSGATRSGKDPPTMGVASPQRRSSSNANLRRDSSVSSSKAVPVPPTRNSRNSFSNIPRASLGGANSNAAVSTGAPPPSFSRQSSSSTATSSSSITAGVTSGVALQQSASTSAMQRHPPSQPTRRSLHNFRTRSTGTGAAAGKPGAAVTSAAATSAGASSAAASNENNELPSDLEVVVSDVENLVS

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
A0A0B4LHU2A0A0B4LHU2_DROMEKul985

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias272-286Polar residues
Compositional bias1022-1038Polar residues
Compositional bias1039-1062Basic and acidic residues
Compositional bias1122-1148Polar residues
Compositional bias1186-1207Polar residues
Compositional bias1254-1323Polar residues
Compositional bias1336-1359Polar residues
Compositional bias1369-1487Polar residues
Compositional bias1503-1523Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AE014297
EMBL· GenBank· DDBJ
AAF56926.1
EMBL· GenBank· DDBJ
Genomic DNA
AE014297
EMBL· GenBank· DDBJ
AHN57588.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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