Q9VAI2 · Q9VAI2_DROME
- ProteinADAM10 endopeptidase
- GeneKul
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids1537 (go to sequence)
- Protein existencePredicted
- Annotation score4/5
Function
Cofactor
Features
Showing features for binding site, active site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | membrane | |
Cellular Component | plasma membrane | |
Molecular Function | metal ion binding | |
Molecular Function | metalloendopeptidase activity | |
Biological Process | membrane protein ectodomain proteolysis | |
Biological Process | Notch signaling pathway |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Protein family/group databases
Names & Taxonomy
Protein names
- Recommended nameADAM10 endopeptidase
- EC number
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Brachycera > Muscomorpha > Ephydroidea > Drosophilidae > Drosophila > Sophophora
Accessions
- Primary accessionQ9VAI2
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Membrane ; Single-pass type I membrane protein
PTM/Processing
Features
Showing features for signal, chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-26 | |||||
Sequence: MSWLLGLLGLQVLFLWLLWLPGEILA | ||||||
Chain | PRO_5015100025 | 27-1537 | ADAM10 endopeptidase | |||
Sequence: IPTPLKLPGYTHRLTPYIKHWEAANFDRQVLQAAQVRHLEQARFRQKREVTPSASGLAHTIRLNFSAHDRDFRLVLRQQPHSVFAHDVEIENTLGPIDYDVSRIYTGSLEDDEAAHVQAILTSDNLLDGTIETQAEHYYIEPAHRYSQQLAESGVHSIVYKLSDVNMQKQQFTGGGLNSATPAKTHCASEKLRKKRWLPEELAMSDAPAPTYNRNPPLPLDLEVPYNDDFRVLASEEDKSEESPRKYPTTSTTRSTVRSTESFLATLTKPTSNRNILVNNYNPSNLGEGSRSYSSGNNNANSNSNNNNSNNNNNNNNSNNNVRKLYTKHKNIIVSTYNRPIEPEFGTPYEEPNNNGTRELPSNFFNANWTTLFLGNNNNGNDRPSHKTHVEIITKNGATKKPNIIVNNYNPEIIFAPNPHNPSFNSMMMTNLLSGRGGEDIHSSPRLLYDRKTTCMLYLQADHTFFQKMGSDEASIEAITRHVQRANTIYRNTDFNNDGKPDNITFMIKRIKVHNMNAMKDPSYRFPGNYGVEKFLELFSEEDYDAFCLAYMFTYRDFEMGTLGLAWTGDLKNAGGVCEKNGHYRGSLKSLNTGIVTLLNYGKHVPPAVSHVTLAHEIGHNFGSPHDPEQCTPGGEDGNFIMFARATSGDKKNNNKFSTCSLKSIEPVLNAKARSMKGCFTEPQSSICGNGVVEPGEQCDCGWEEDCKDSCCFPMSRQPRLDETPCTLTPHARCSPSQGPCCTTDCKLKFGDKCRDDNGCRDPSFCDGRVPQCPPSVNKPNKTICNKEFVCYMGDCTGSICLAYGLESCQCIPGPQDDRIKSCELCCKLPGEDSPCRSSFEWNEAPFDVPDMYSKPGTPCNDYNGYCDVFQKCREVDPSGPLATLRKLLLSEESIASFKKWMQHNWYTVALAAVGVILLLALSTKLLAKRSNLKLKSVTIIHSATTETVRLPENNNGVIVHTAVRTKVPFKKKVRGERTKKPGTGAGVTAAAAVGTRNAAKSSANPEPKKTTRSQAMAKKKSFEEEPKKSSKKVGKHMKEIIDYSNRNNNGDDASNLSTTNNHTNTFGKVQKWLLESPIVAQPLSHIEHSSRVRKVMSKSQSTPERLVQKTPQKTKSMGNLSNEKVKLQVVYKPPFKFSLRLSKKPKVKTHVVGAGVRPKRSQKTSNRTGGQSSSKEVSTRAKRSALLLCNEAEDDNQILTLNEPNYETLKPPTPPRSMEHCYENVDMQAEASSSKPSSSSKVAPSSQNRASLEVTPPVTAQRNSYRRSNSLSTHNPFAAAPRRSSSKASGSVNLTRNFGSTQNLINLSQNLSKNKKRSSLNLKASGSGATRSGKDPPTMGVASPQRRSSSNANLRRDSSVSSSKAVPVPPTRNSRNSFSNIPRASLGGANSNAAVSTGAPPPSFSRQSSSSTATSSSSITAGVTSGVALQQSASTSAMQRHPPSQPTRRSLHNFRTRSTGTGAAAGKPGAAVTSAAATSAGASSAAASNENNELPSDLEVVVSDVENLVS |
Keywords
- PTM
Proteomic databases
Expression
Gene expression databases
Structure
Family & Domains
Features
Showing features for region, compositional bias, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 260-286 | Disordered | ||||
Sequence: ASEEDKSEESPRKYPTTSTTRSTVRST | ||||||
Compositional bias | 272-286 | Polar residues | ||||
Sequence: KYPTTSTTRSTVRST | ||||||
Region | 300-348 | Disordered | ||||
Sequence: RNILVNNYNPSNLGEGSRSYSSGNNNANSNSNNNNSNNNNNNNNSNNNV | ||||||
Domain | 479-696 | Peptidase M12B | ||||
Sequence: TTCMLYLQADHTFFQKMGSDEASIEAITRHVQRANTIYRNTDFNNDGKPDNITFMIKRIKVHNMNAMKDPSYRFPGNYGVEKFLELFSEEDYDAFCLAYMFTYRDFEMGTLGLAWTGDLKNAGGVCEKNGHYRGSLKSLNTGIVTLLNYGKHVPPAVSHVTLAHEIGHNFGSPHDPEQCTPGGEDGNFIMFARATSGDKKNNNKFSTCSLKSIEPVLN | ||||||
Domain | 711-807 | Disintegrin | ||||
Sequence: SSICGNGVVEPGEQCDCGWEEDCKDSCCFPMSRQPRLDETPCTLTPHARCSPSQGPCCTTDCKLKFGDKCRDDNGCRDPSFCDGRVPQCPPSVNKPN | ||||||
Region | 1021-1062 | Disordered | ||||
Sequence: GTRNAAKSSANPEPKKTTRSQAMAKKKSFEEEPKKSSKKVGK | ||||||
Compositional bias | 1022-1038 | Polar residues | ||||
Sequence: TRNAAKSSANPEPKKTT | ||||||
Compositional bias | 1039-1062 | Basic and acidic residues | ||||
Sequence: RSQAMAKKKSFEEEPKKSSKKVGK | ||||||
Region | 1070-1089 | Disordered | ||||
Sequence: YSNRNNNGDDASNLSTTNNH | ||||||
Region | 1116-1148 | Disordered | ||||
Sequence: SSRVRKVMSKSQSTPERLVQKTPQKTKSMGNLS | ||||||
Compositional bias | 1122-1148 | Polar residues | ||||
Sequence: VMSKSQSTPERLVQKTPQKTKSMGNLS | ||||||
Region | 1173-1207 | Disordered | ||||
Sequence: KVKTHVVGAGVRPKRSQKTSNRTGGQSSSKEVSTR | ||||||
Compositional bias | 1186-1207 | Polar residues | ||||
Sequence: KRSQKTSNRTGGQSSSKEVSTR | ||||||
Region | 1225-1323 | Disordered | ||||
Sequence: ILTLNEPNYETLKPPTPPRSMEHCYENVDMQAEASSSKPSSSSKVAPSSQNRASLEVTPPVTAQRNSYRRSNSLSTHNPFAAAPRRSSSKASGSVNLTR | ||||||
Compositional bias | 1254-1323 | Polar residues | ||||
Sequence: MQAEASSSKPSSSSKVAPSSQNRASLEVTPPVTAQRNSYRRSNSLSTHNPFAAAPRRSSSKASGSVNLTR | ||||||
Compositional bias | 1336-1359 | Polar residues | ||||
Sequence: QNLSKNKKRSSLNLKASGSGATRS | ||||||
Region | 1336-1537 | Disordered | ||||
Sequence: QNLSKNKKRSSLNLKASGSGATRSGKDPPTMGVASPQRRSSSNANLRRDSSVSSSKAVPVPPTRNSRNSFSNIPRASLGGANSNAAVSTGAPPPSFSRQSSSSTATSSSSITAGVTSGVALQQSASTSAMQRHPPSQPTRRSLHNFRTRSTGTGAAAGKPGAAVTSAAATSAGASSAAASNENNELPSDLEVVVSDVENLVS | ||||||
Compositional bias | 1369-1487 | Polar residues | ||||
Sequence: ASPQRRSSSNANLRRDSSVSSSKAVPVPPTRNSRNSFSNIPRASLGGANSNAAVSTGAPPPSFSRQSSSSTATSSSSITAGVTSGVALQQSASTSAMQRHPPSQPTRRSLHNFRTRSTG | ||||||
Compositional bias | 1503-1523 | Polar residues | ||||
Sequence: AATSAGASSAAASNENNELPS |
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,537
- Mass (Da)168,797
- Last updated2000-05-01 v1
- Checksum46A52344A8E73617
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A0B4LHU2 | A0A0B4LHU2_DROME | Kul | 985 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 272-286 | Polar residues | ||||
Sequence: KYPTTSTTRSTVRST | ||||||
Compositional bias | 1022-1038 | Polar residues | ||||
Sequence: TRNAAKSSANPEPKKTT | ||||||
Compositional bias | 1039-1062 | Basic and acidic residues | ||||
Sequence: RSQAMAKKKSFEEEPKKSSKKVGK | ||||||
Compositional bias | 1122-1148 | Polar residues | ||||
Sequence: VMSKSQSTPERLVQKTPQKTKSMGNLS | ||||||
Compositional bias | 1186-1207 | Polar residues | ||||
Sequence: KRSQKTSNRTGGQSSSKEVSTR | ||||||
Compositional bias | 1254-1323 | Polar residues | ||||
Sequence: MQAEASSSKPSSSSKVAPSSQNRASLEVTPPVTAQRNSYRRSNSLSTHNPFAAAPRRSSSKASGSVNLTR | ||||||
Compositional bias | 1336-1359 | Polar residues | ||||
Sequence: QNLSKNKKRSSLNLKASGSGATRS | ||||||
Compositional bias | 1369-1487 | Polar residues | ||||
Sequence: ASPQRRSSSNANLRRDSSVSSSKAVPVPPTRNSRNSFSNIPRASLGGANSNAAVSTGAPPPSFSRQSSSSTATSSSSITAGVTSGVALQQSASTSAMQRHPPSQPTRRSLHNFRTRSTG | ||||||
Compositional bias | 1503-1523 | Polar residues | ||||
Sequence: AATSAGASSAAASNENNELPS |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AE014297 EMBL· GenBank· DDBJ | AAF56926.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AE014297 EMBL· GenBank· DDBJ | AHN57588.1 EMBL· GenBank· DDBJ | Genomic DNA |