Q9V9A7 · MCCB_DROME

  • Protein
    Probable methylcrotonoyl-CoA carboxylase beta chain, mitochondrial
  • Gene
    Mccc2
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at transcript level
  • Annotation score
    4/5

Function

function

Carboxyltransferase subunit of the 3-methylcrotonyl-CoA carboxylase, an enzyme that catalyzes the conversion of 3-methylcrotonyl-CoA to 3-methylglutaconyl-CoA, a critical step for leucine and isovaleric acid catabolism (By similarity).
Vital for adult survival

Catalytic activity

Pathway

Amino-acid degradation; L-leucine degradation; (S)-3-hydroxy-3-methylglutaryl-CoA from 3-isovaleryl-CoA: step 2/3.

GO annotations

AspectTerm
Cellular Component3-methylcrotonyl-CoA carboxylase complex, mitochondrial
Cellular Componentmethylcrotonoyl-CoA carboxylase complex
Cellular Componentmitochondrial matrix
Cellular Componentmitochondrion
Molecular FunctionATP binding
Molecular Functionmethylcrotonoyl-CoA carboxylase activity
Biological Processcoenzyme A metabolic process
Biological ProcessL-leucine catabolic process
Biological Processregulation of eclosion

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Probable methylcrotonoyl-CoA carboxylase beta chain, mitochondrial
  • EC number
  • Short names
    MCCase subunit beta
  • Alternative names
    • 3-methylcrotonyl-CoA carboxylase 2
    • 3-methylcrotonyl-CoA carboxylase non-biotin-containing subunit
    • 3-methylcrotonyl-CoA:carbon dioxide ligase subunit beta

Gene names

    • Name
      Mccc2
    • Synonyms
      l(2)04524
    • ORF names
      CG3267

Organism names

  • Taxonomic identifier
  • Strain
    • Berkeley
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Brachycera > Muscomorpha > Ephydroidea > Drosophilidae > Drosophila > Sophophora

Accessions

  • Primary accession
    Q9V9A7
  • Secondary accessions
    • O18364
    • Q8SXT5

Proteomes

Organism-specific databases

PTM/Processing

Features

Showing features for transit peptide, chain.

TypeIDPosition(s)Description
Transit peptide1-29Mitochondrion
ChainPRO_000000029730-578Probable methylcrotonoyl-CoA carboxylase beta chain, mitochondrial

Proteomic databases

Expression

Tissue specificity

Expressed in third instar larval ring gland (lateral and medial secretory cells and corpus cardiacum cells) and CNS.

Gene expression databases

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for domain, region.

TypeIDPosition(s)Description
Domain48-305CoA carboxyltransferase N-terminal
Region48-570Carboxyltransferase
Domain321-570CoA carboxyltransferase C-terminal
Region355-388Acyl-CoA binding

Sequence similarities

Belongs to the AccD/PCCB family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    578
  • Mass (Da)
    62,648
  • Last updated
    2000-05-01 v1
  • Checksum
    AF5E2ABBE36B18F0
MIRLNWLFRSSSVLLRSQVRLLHVGDANVLHSEVDKQSAEYKENAREMASLVGDLRNFTSQVLKGGGQKAIERHTSRGKLLARERINLLLDKGSPFLELSALAGHELYGEEVVNSGGIVTGVGRVCGTECLVVANDATVKGGSYYPITVKKHLRAQEIAQENRLPCIYLVDSGGANLPRQADVFPDKLHFGRIFYNQANMSAQGIPQIAVVMGSCTAGGAYVPAMADESIIVKKQGTIFLAGPPLVKAATGEEVSAEDLGGADLHCKTSGVTDHYALDDEHALYLARQIVSNLNLSATNSYNDQLMHSSQVNFQTATPPSAVEEPRYDAEELYGIVGPNLTKSFDVREVIARIVDGSRFTEFKKLYGETLVCGFAKLYGHTVGIVGNNGVLFSESALKGAHFIQLCAQRKIPLVFLQNITGFMVGRDAEANGIAKNGAKMVTAVACANVPKFTVIIGGSYGAGNYGMCGRAYSPRFLYMWPNSRISVMGGTQAANVMAQITEDQRKRAGKEFSEEEAQKLKAPIVEMFEAEGSPYYSTARLWDDGIIDPANTRQILGLSLKAALNNAGQETKFGVFRM

Features

Showing features for sequence conflict.

TypeIDPosition(s)Description
Sequence conflict50in Ref. 4; no nucleotide entry
Sequence conflict96in Ref. 4; no nucleotide entry
Sequence conflict274in Ref. 3; AAL89883
Sequence conflict277in Ref. 4; no nucleotide entry
Sequence conflict330in Ref. 4; no nucleotide entry
Sequence conflict376-377in Ref. 4; no nucleotide entry
Sequence conflict422in Ref. 4; no nucleotide entry

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AE013599
EMBL· GenBank· DDBJ
AAM70824.1
EMBL· GenBank· DDBJ
Genomic DNA
AF006654
EMBL· GenBank· DDBJ
AAB62570.1
EMBL· GenBank· DDBJ
mRNA
AY084145
EMBL· GenBank· DDBJ
AAL89883.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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