Q9V6Q2 · CID_DROME

Function

function

Histone H3-like variant which exclusively replaces conventional H3 in the nucleosome core of centromeric chromatin at the inner plate of the kinetochore (PubMed:11483958, PubMed:16839185).
Required for recruitment and assembly of kinetochore proteins, mitotic progression and chromosome segregation (PubMed:11483958, PubMed:16839185, PubMed:24703848).
May serve as an epigenetic mark that propagates centromere identity through replication and cell division (PubMed:11483958, PubMed:16839185).

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular ComponentCENP-A containing nucleosome
Cellular Componentchromosome, centromeric region
Cellular Componentcondensed chromosome, centromeric region
Cellular Componentinner kinetochore
Cellular Componentkinetochore
Cellular Componentnucleosome
Cellular Componentnucleus
Molecular FunctionDNA binding
Molecular Functionprotein heterodimerization activity
Molecular Functionstructural constituent of chromatin
Biological Processchromosome segregation
Biological Processheterochromatin formation
Biological Processkinetochore assembly
Biological Processkinetochore organization
Biological Processmitotic cell cycle
Biological Processmitotic metaphase chromosome alignment
Biological Processspindle assembly

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Histone H3-like centromeric protein cid
  • Alternative names
    • CENP-A homolog
    • Centromere identifier protein

Gene names

    • Name
      cid
    • Synonyms
      CENP-A
    • ORF names
      CG13329

Organism names

  • Taxonomic identifier
  • Strains
    • Antigua
    • In
    • Melbourne
    • Oregon-R
    • Tai 255.1
    • Berkeley
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Brachycera > Muscomorpha > Ephydroidea > Drosophilidae > Drosophila > Sophophora

Accessions

  • Primary accession
    Q9V6Q2
  • Secondary accessions
    • Q7YUD4
    • Q7YUD5
    • Q8MQP5
    • Q9NG62

Proteomes

Organism-specific databases

Subcellular Location

Keywords

Phenotypes & Variants

Features

Showing features for natural variant.

TypeIDPosition(s)Description
Natural variant113-114in strain: Tai 255.1

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 1 variant from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

PTM/Processing

Features

Showing features for chain, modified residue.

Type
IDPosition(s)Description
ChainPRO_00002494741-225Histone H3-like centromeric protein cid
Modified residue74Phosphoserine
Modified residue75Phosphoserine
Modified residue76Phosphothreonine
Modified residue77Phosphoserine

Keywords

Proteomic databases

PTM databases

Expression

Gene expression databases

Interaction

Subunit

Forms a nucleosome-like histone octamer containing two molecules each of H2A, H2B, cid and H4 assembled in one cid-H4 heterotetramer and two H2A-H2B heterodimers (By similarity).
The cid-H4 heterotetramer is more compact and structurally more rigid than corresponding H3-H4 heterotetramers (By similarity).
Interacts with the condensin subunit Cap-G (PubMed:15592865).
Interacts with Chrac-14 (PubMed:24703848).

Binary interactions

TypeEntry 1Entry 2Number of experimentsIntAct
BINARY Q9V6Q2Caf1-55 Q245726EBI-129287, EBI-75924
BINARY Q9V6Q2His2A:CG33865 P840512EBI-129287, EBI-182580

Protein-protein interaction databases

Family & Domains

Features

Showing features for region, compositional bias.

Type
IDPosition(s)Description
Region1-131Disordered
Compositional bias40-55Polar residues
Compositional bias56-87Basic and acidic residues
Compositional bias88-123Polar residues
Region133-225H3-like

Sequence similarities

Belongs to the histone H3 family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    225
  • Mass (Da)
    25,968
  • Last updated
    2002-10-01 v2
  • Checksum
    E125327C4EDD12D2
MPRHSRAKRAPRPSANNSKSPNDDDTAFRSPEPEDGTDYGLEFTTSQLTLQDNNRRSSTLRRDAGRRQPAARDSSTSGEEEDQENRYPTTRSPQTRRMTVQQESKTRAAGPVAAQNQTRRRKAANPMSRAKRMDREIRRLQHHPGTLIPKLPFSRLVREFIVKYSDDEPLRVTEGALLAMQESCEMYLTQRLADSYMLTKHRNRVTLEVRDMALMAYICDRGRQF

Sequence caution

The sequence AAM75058.1 differs from that shown. Reason: Frameshift

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias40-55Polar residues
Compositional bias56-87Basic and acidic residues
Compositional bias88-123Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF259371
EMBL· GenBank· DDBJ
AAF72652.1
EMBL· GenBank· DDBJ
Genomic DNA
AY126929
EMBL· GenBank· DDBJ
AAM80987.1
EMBL· GenBank· DDBJ
Genomic DNA
AY126930
EMBL· GenBank· DDBJ
AAM80988.1
EMBL· GenBank· DDBJ
Genomic DNA
AY126931
EMBL· GenBank· DDBJ
AAM80989.1
EMBL· GenBank· DDBJ
Genomic DNA
AY126932
EMBL· GenBank· DDBJ
AAM80990.1
EMBL· GenBank· DDBJ
Genomic DNA
AY126933
EMBL· GenBank· DDBJ
AAM80991.1
EMBL· GenBank· DDBJ
Genomic DNA
AE013599
EMBL· GenBank· DDBJ
AAF58371.2
EMBL· GenBank· DDBJ
Genomic DNA
AY128465
EMBL· GenBank· DDBJ
AAM75058.1
EMBL· GenBank· DDBJ
mRNA Frameshift

Genome annotation databases

Similar Proteins

Disclaimer

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