Q9V6Q2 · CID_DROME
- ProteinHistone H3-like centromeric protein cid
- Genecid
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids225 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Histone H3-like variant which exclusively replaces conventional H3 in the nucleosome core of centromeric chromatin at the inner plate of the kinetochore (PubMed:11483958, PubMed:16839185).
Required for recruitment and assembly of kinetochore proteins, mitotic progression and chromosome segregation (PubMed:11483958, PubMed:16839185, PubMed:24703848).
May serve as an epigenetic mark that propagates centromere identity through replication and cell division (PubMed:11483958, PubMed:16839185).
Required for recruitment and assembly of kinetochore proteins, mitotic progression and chromosome segregation (PubMed:11483958, PubMed:16839185, PubMed:24703848).
May serve as an epigenetic mark that propagates centromere identity through replication and cell division (PubMed:11483958, PubMed:16839185).
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | CENP-A containing nucleosome | |
Cellular Component | chromosome, centromeric region | |
Cellular Component | condensed chromosome, centromeric region | |
Cellular Component | inner kinetochore | |
Cellular Component | kinetochore | |
Cellular Component | nucleosome | |
Cellular Component | nucleus | |
Molecular Function | DNA binding | |
Molecular Function | protein heterodimerization activity | |
Molecular Function | structural constituent of chromatin | |
Biological Process | chromosome segregation | |
Biological Process | heterochromatin formation | |
Biological Process | kinetochore assembly | |
Biological Process | kinetochore organization | |
Biological Process | mitotic cell cycle | |
Biological Process | mitotic metaphase chromosome alignment | |
Biological Process | spindle assembly |
Keywords
- Molecular function
Names & Taxonomy
Protein names
- Recommended nameHistone H3-like centromeric protein cid
- Alternative names
Gene names
Organism names
- Strains
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Brachycera > Muscomorpha > Ephydroidea > Drosophilidae > Drosophila > Sophophora
Accessions
- Primary accessionQ9V6Q2
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Note: Localizes exclusively in the kinetochore domain of centromeres. Co-expressed with yemalpha.
Keywords
- Cellular component
Phenotypes & Variants
Features
Showing features for natural variant.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Natural variant | 113-114 | in strain: Tai 255.1 | |||
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 1 variant from UniProt as well as other sources including ClinVar and dbSNP.
PTM/Processing
Features
Showing features for chain, modified residue.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000249474 | 1-225 | Histone H3-like centromeric protein cid | ||
Modified residue | 74 | Phosphoserine | |||
Modified residue | 75 | Phosphoserine | |||
Modified residue | 76 | Phosphothreonine | |||
Modified residue | 77 | Phosphoserine | |||
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Gene expression databases
Interaction
Subunit
Forms a nucleosome-like histone octamer containing two molecules each of H2A, H2B, cid and H4 assembled in one cid-H4 heterotetramer and two H2A-H2B heterodimers (By similarity).
The cid-H4 heterotetramer is more compact and structurally more rigid than corresponding H3-H4 heterotetramers (By similarity).
Interacts with the condensin subunit Cap-G (PubMed:15592865).
Interacts with Chrac-14 (PubMed:24703848).
The cid-H4 heterotetramer is more compact and structurally more rigid than corresponding H3-H4 heterotetramers (By similarity).
Interacts with the condensin subunit Cap-G (PubMed:15592865).
Interacts with Chrac-14 (PubMed:24703848).
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | IntAct | |
---|---|---|---|---|---|
BINARY | Q9V6Q2 | Caf1-55 Q24572 | 6 | EBI-129287, EBI-75924 | |
BINARY | Q9V6Q2 | His2A:CG33865 P84051 | 2 | EBI-129287, EBI-182580 |
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for region, compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Region | 1-131 | Disordered | |||
Compositional bias | 40-55 | Polar residues | |||
Compositional bias | 56-87 | Basic and acidic residues | |||
Compositional bias | 88-123 | Polar residues | |||
Region | 133-225 | H3-like | |||
Sequence similarities
Belongs to the histone H3 family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length225
- Mass (Da)25,968
- Last updated2002-10-01 v2
- ChecksumE125327C4EDD12D2
Sequence caution
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 40-55 | Polar residues | |||
Compositional bias | 56-87 | Basic and acidic residues | |||
Compositional bias | 88-123 | Polar residues | |||
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AF259371 EMBL· GenBank· DDBJ | AAF72652.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY126929 EMBL· GenBank· DDBJ | AAM80987.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY126930 EMBL· GenBank· DDBJ | AAM80988.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY126931 EMBL· GenBank· DDBJ | AAM80989.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY126932 EMBL· GenBank· DDBJ | AAM80990.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY126933 EMBL· GenBank· DDBJ | AAM80991.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AE013599 EMBL· GenBank· DDBJ | AAF58371.2 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY128465 EMBL· GenBank· DDBJ | AAM75058.1 EMBL· GenBank· DDBJ | mRNA | Frameshift |